SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Cox Kerry L) "

Sökning: WFRF:(Cox Kerry L)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Roghanian, Ali, et al. (författare)
  • Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo.
  • 2015
  • Ingår i: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 27:4, s. 473-488
  • Tidskriftsartikel (refereegranskat)abstract
    • Therapeutic antibodies have transformed cancer therapy, unlocking mechanisms of action by engaging the immune system. Unfortunately, cures rarely occur and patients display intrinsic or acquired resistance. Here, we demonstrate the therapeutic potential of targeting human (h) FcγRIIB (CD32B), a receptor implicated in immune cell desensitization and tumor cell resistance. FcγRIIB-blocking antibodies prevented internalization of the CD20-specific antibody rituximab, thereby maximizing cell surface accessibility and immune effector cell mediated antitumor activity. In hFcγRIIB-transgenic (Tg) mice, FcγRIIB-blocking antibodies effectively deleted target cells in combination with rituximab, and other therapeutic antibodies, from resistance-prone stromal compartments. Similar efficacy was seen in primary human tumor xenografts, including with cells from patients with relapsed/refractory disease. These data support the further development of hFcγRIIB antibodies for clinical assessment.
  •  
2.
  • Fazey, Ioan, et al. (författare)
  • Transforming knowledge systems for life on Earth : Visions of future systems and how to get there
  • 2020
  • Ingår i: Energy Research & Social Science. - : Elsevier. - 2214-6296 .- 2214-6326. ; 70
  • Tidskriftsartikel (refereegranskat)abstract
    • Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Jerkeman, Mats (1)
Olsson, Per (1)
Hansson, Markus (1)
Adams, David (1)
O'Brien, Karen (1)
Aldunce, Paulina (1)
visa fler...
Nilsson, Björn (1)
Juliusson, Gunnar (1)
Pereira, Laura (1)
Galafassi, Diego (1)
Moore, Michele-Lee (1)
Luederitz, Christoph ... (1)
Light, Ann (1)
Davies, Andrew (1)
Andersson, Lotta (1)
Hesselgren, Mia, 196 ... (1)
Anderson, Lakin (1)
Ryan, Paul (1)
Peukert, Daniela (1)
Washbourne, Carla-Le ... (1)
Sebhatu, Samuel Petr ... (1)
Holmen, Johan (1)
Singh, Chandni (1)
Tschakert, Petra (1)
Hamann, Maike (1)
Luthe, Tobias (1)
Barrie, Jack (1)
Lang, Daniel J. (1)
Russell, Shona (1)
Preiser, Rika (1)
Schäpke, Niko Alexan ... (1)
Bergsten, Arvid (1)
Cragg, Mark S (1)
Cockburn, Jessica (1)
Cornforth, Rosalind (1)
Patterson, James (1)
Young, Hannah R. (1)
Bradbury, Hilary (1)
Caniglia, Guido (1)
Ryan, Melanie (1)
Charli-Joseph, Laksh ... (1)
Horcea-Milcu, Andra- ... (1)
Ross, Helen (1)
Reed, Mark S. (1)
Dannevig, Halvor (1)
Frendeus, Björn (1)
Carmen, Esther (1)
Woods, Mel (1)
Marshall, Fiona (1)
Egermann, Markus (1)
visa färre...
Lärosäte
Lunds universitet (2)
Kungliga Tekniska Högskolan (1)
Uppsala universitet (1)
Stockholms universitet (1)
Chalmers tekniska högskola (1)
Karlstads universitet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
Medicin och hälsovetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy