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- Robba, Chiara, et al.
(författare)
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Oxygen targets and 6-month outcome after out of hospital cardiac arrest : a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
- 2022
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Ingår i: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535 .- 1466-609X. ; 26, s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO2 with patients’ outcome. Methods: Preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after OHCA (TTM2) trial. Arterial blood gases values were collected from randomization every 4 h for the first 32 h, and then, every 8 h until day 3. Hypoxemia was defined as PaO2 < 60 mmHg and severe hyperoxemia as PaO2 > 300 mmHg. Mortality and poor neurological outcome (defined according to modified Rankin scale) were collected at 6 months. Results: 1418 patients were included in the analysis. The mean age was 64 ± 14 years, and 292 patients (20.6%) were female. 24.9% of patients had at least one episode of hypoxemia, and 7.6% of patients had at least one episode of severe hyperoxemia. Both hypoxemia and hyperoxemia were independently associated with 6-month mortality, but not with poor neurological outcome. The best cutoff point associated with 6-month mortality for hypoxemia was 69 mmHg (Risk Ratio, RR = 1.009, 95% CI 0.93–1.09), and for hyperoxemia was 195 mmHg (RR = 1.006, 95% CI 0.95–1.06). The time exposure, i.e., the area under the curve (PaO2-AUC), for hyperoxemia was significantly associated with mortality (p = 0.003). Conclusions: In OHCA patients, both hypoxemia and hyperoxemia are associated with 6-months mortality, with an effect mediated by the timing exposure to high values of oxygen. Precise titration of oxygen levels should be considered in this group of patients. Trial registration: clinicaltrials.gov NCT02908308, Registered September 20, 2016.
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| 2. |
- Robba, Chiara, et al.
(författare)
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Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients : a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
- 2022
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Ingår i: Intensive Care Medicine. - : Springer Science and Business Media LLC. - 0342-4642 .- 1432-1238. ; 48:8, s. 1024-1038
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of mechanical ventilation in patients after out-of-hospital cardiac arrest and their association with 6-month outcomes. Methods: Preplanned sub-analysis of the Target Temperature Management-2 trial. Clinical outcomes were mortality and functional status (assessed by the Modified Rankin Scale) 6 months after randomization. Results: A total of 1848 patients were included (mean age 64 [Standard Deviation, SD = 14] years). At 6 months, 950 (51%) patients were alive and 898 (49%) were dead. Median tidal volume (VT) was 7 (Interquartile range, IQR = 6.2–8.5) mL per Predicted Body Weight (PBW), positive end expiratory pressure (PEEP) was 7 (IQR = 5–9) cmH20, plateau pressure was 20 cmH20 (IQR = 17–23), driving pressure was 12 cmH20 (IQR = 10–15), mechanical power 16.2 J/min (IQR = 12.1–21.8), ventilatory ratio was 1.27 (IQR = 1.04–1.6), and respiratory rate was 17 breaths/minute (IQR = 14–20). Median partial pressure of oxygen was 87 mmHg (IQR = 75–105), and partial pressure of carbon dioxide was 40.5 mmHg (IQR = 36–45.7). Respiratory rate, driving pressure, and mechanical power were independently associated with 6-month mortality (omnibus p-values for their non-linear trajectories: p < 0.0001, p = 0.026, and p = 0.029, respectively). Respiratory rate and driving pressure were also independently associated with poor neurological outcome (odds ratio, OR = 1.035, 95% confidence interval, CI = 1.003–1.068, p = 0.030, and OR = 1.005, 95% CI = 1.001–1.036, p = 0.048). A composite formula calculated as [(4*driving pressure) + respiratory rate] was independently associated with mortality and poor neurological outcome. Conclusions: Protective ventilation strategies are commonly applied in patients after cardiac arrest. Ventilator settings in the first 72 h after hospital admission, in particular driving pressure and respiratory rate, may influence 6-month outcomes.
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| 3. |
- Carling, Gerd, et al.
(författare)
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DiACL : Diachronic Atlas of Comparative Linguistics
- 2017
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- DiACL is an open access database with lexical and typological/morphosyntactic data for historical, comparative and phylogenetic linguistics. It contains data from 500 languages of 18 families, divided into three macro-areas: Eurasia, Pacific, and the Amazon.
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| 4. |
- Spikol, Daniel
(creator_code:cre_t, creator_code:res_t)
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Forskarnas galleri #5 : People have the power: IOTAP on exhibit
- 2018
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Konstnärligt arbeteabstract
- Överallt samlar sensorer data som analyseras för att räkna ut hur man sparar energi, hur mycket insulin som ska injiceras, var den närmaste hyrbilen finns, hur många människor som fortfarande är kvar inne i en brinnande byggnad... Denna snabba spridning av teknik kallas för Sakernas Internet, eller IoT. Människor har makten, eller har vi verkligen det? Hur mycket värderar vi vår integritet? Vilka internetanslutna gadgets hjälper oss att leva ett hälsosamt och hållbart liv - och vilka prylar kommer bara att öka vår stressnivå? När blir användningen missbruk? Utställningen undersöker hur IoT påverkar människor, samhälle och industri. Forskningsprojekt i utställningen: Emergent Configuration for IoT Systems (ECOS+), Smart energy management and security (SEMS), Fair Data, Walk the ward, Dynamic Intelligent Sensor-Intensive Systems (DISS), PELARS-projektet och Busrunner presenteras i "IOTAP-labbet"
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| 6. |
- Bailey, Matthew H., et al.
(författare)
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- 2020
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts.
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| 7. |
- Hansson, Per
(creator_code:cre_t)
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BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT
- 2015
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- A blood treatment apparatus (2) comprising: a blood treatment unit (10); a blood line (20) configured to extract blood from a blood source (21), pass the blood through the blood treatment unit (10) and deliver treated blood to a target vessel (22); and a fluid line (30) configured pass treatment fluid through the blood treatment unit (10) and deliver used treatment fluid to a fluid sink (32). A flow divider (40) is arranged in the fluid line (30) separates treatment fluid into to a first fluid section (51) and a second fluid section (53), thereby electrically isolating the fluid sections (51, 53) such that electrical current flowing in the fluid line (30) between the fluid sections (51, 53) is limited. Related manufacturing and verification methods are also described.
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| 8. |
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| 9. |
- Galli, Siliva
(creator_code:cre_t)
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Forskarnas galleri #4 : Förnuft eller känsla? Fakta, forskning och föreställningar
- 2018
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Konstnärligt arbeteabstract
- Forskning är en komplex process som ifrågasätter, undersöker och utvecklar nya aspekter av världen. På så sätt rör sig forskningsfälten hela tiden framåt. Forskningens rön och resultat sprids sedan på många sätt, till exempel genom vetenskaplig publicering, samverkan, forskarnätverk eller genom utställningar. I denna utställning presenterar biblioteket forskning från Malmö universitets fem fakulteter. När forskning når en bred publik är den förenklad och ofta tagen ur sin kontext. Det gör att forskningresultat i den snabba nyhetsrapporteringen lätt misstolkas eller missuppfattas. Enskilda resultat är en del av ett större sammanhang och fungerar därför sällan som nyhetsrubriker. Utställningen belyser vikten av att granska all information kritiskt och uppmanar dig som besökare att fundera på om du tar till dig nyheter med förnuft eller känsla.
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