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| 2. |
- Yusuf, D, et al.
(författare)
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The transcription factor encyclopedia
- 2012
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906. ; 13:3, s. R24-
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Izzo, A, et al.
(författare)
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Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses
- 2017
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Ingår i: International journal of genomics. - : Hindawi Limited. - 2314-436X .- 2314-4378. ; 2017, s. 8737649-
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Tidskriftsartikel (refereegranskat)abstract
- Dosage-dependent upregulation of most of chromosome 21 (Hsa21) genes has been demonstrated in heart tissues of fetuses with Down syndrome (DS). Also miRNAs might play important roles in the cardiac phenotype as they are highly expressed in the heart and regulate cardiac development. Five Hsa21 miRNAs have been well studied in the past: miR-99a-5p, miR-125b-2-5p, let-7c-5p, miR-155-5p, and miR-802-5p but few information is available about their expression in trisomic tissues. In this study, we evaluated the expression of these miRNAs in heart tissues from DS fetuses, showing that miR-99a-5p, miR-155-5p, and let-7c-5p were overexpressed in trisomic hearts. To investigate their role, predicted targets were obtained from different databases and cross-validated using the gene expression profiling dataset we previously generated for fetal hearts. Eighty-five targets of let-7c-5p, 33 of miR-155-5p, and 10 of miR-99a-5p were expressed in fetal heart and downregulated in trisomic hearts. As nuclear encoded mitochondrial genes were found downregulated in trisomic hearts and mitochondrial dysfunction is a hallmark of DS phenotypes, we put special attention to let-7c-5p and miR-155-5p targets downregulated in DS fetal hearts and involved in mitochondrial function. The let-7c-5p predicted targetSLC25A4/ANT1was identified as a possible candidate for both mitochondrial and cardiac anomalies.
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| 4. |
- Pucci, M, et al.
(författare)
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On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors
- 2021
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Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- Different neuromodulatory systems are involved in long-term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies.
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| 6. |
- Zhang, Mengmeng, et al.
(författare)
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Investigating the piaggio avanti design using CEASIOM
- 2014
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Ingår i: 29th Congress of the International Council of the Aeronautical Sciences, ICAS 2014. - 3932182804
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Konferensbidrag (refereegranskat)abstract
- In early steps of aircraft design the unification of configuration definition is important to avoid user-input errors. Also coupling with each other can strengthen different tools with different specifications simultaneously provided that the geometry definition is transferred with minimum data loss. This is vitally useful especially when geometry data is transferred in order to perform high- fidelity analysis. This paper reports the analysis for the pitch control of a three-lifting-surface aircraft Piaggio Avanti using CEASIOM, a tool- chain software for aircraft preliminary design, with the baseline configuration coming from the conceptual design code AAA, linked by a common name-space CPACS for the means of data collaboration.
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