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1.	Wang, Li-San, et al. (author) Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States. 2015 In: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 72:2 Journal article (peer-reviewed)abstract Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.

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Author/Editor: Blennow, Kaj, 1958 (1); Zetterberg, Henrik, ... (1); Glass, Jonathan D. (1); Reiman, Eric M. (1); Morris, John C (1); Farlow, Martin R (1); show more...; Cruchaga, Carlos (1); McKee, Ann C (1); Trojanowski, John Q (1); Stern, Robert A (1); Hakonarson, Hakon (1); Buxbaum, Joseph D (1); Geschwind, Daniel H (1); Haines, Jonathan L (1); Pericak-Vance, Marga ... (1); Schellenberg, Gerard ... (1); Lopez, Oscar L. (1); Bird, Thomas D. (1); Seeley, William W. (1); Jarvik, Gail P. (1); Head, Elizabeth (1); Schneider, Lon S (1); Schupf, Nicole (1); Lunetta, Kathryn L (1); Yu, Lei (1); Bennett, David A (1); Boeve, Bradley F (1); Behrens, Timothy W (1); Graham, Robert R (1); Leverenz, James B (1); Blacker, Deborah (1); Tanzi, Rudolph E. (1); Masliah, Eliezer (1); Hyman, Bradley T (1); Ghetti, Bernardino (1); Cairns, Nigel J. (1); Rosen, Howard J. (1); Boxer, Adam (1); Karydas, Anna (1); Honig, Lawrence S (1); Rogaeva, Ekaterina (1); St George-Hyslop, Pe ... (1); Graff-Radford, Neill ... (1); Dickson, Dennis W (1); Quinn, Joseph F. (1); DeCarli, Charles (1); Lyketsos, Constantin ... (1); Goate, Alison M. (1); Kauwe, John S K (1); Petersen, Ronald C. (1); show less...

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