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| 2. |
- Angelucci, F, et al.
(författare)
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The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease
- 2014
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Ingår i: Canadian journal of physiology and pharmacology. - : Canadian Science Publishing. - 1205-7541 .- 0008-4212. ; 92:8, s. 621-630
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer’s disease (AD) is a disorder characterized by the accumulation of abnormally folded protein fragments in neurons, i.e., β-amyloid (Aβ) and tau protein, leading to cell death. Several neuropeptides present in the central nervous system (CNS) are believed to be involved in the pathophysiology of AD. Among them, neuropeptide Y (NPY), a small peptide widely distributed throughout the brain, has generated interest because of its role in neuroprotection against excitotoxicity in animal models of AD. In addition, it has been shown that NPY modulates neurogenesis. Interestingly, these latter effects are similar to those elicited by neurotrophins, which are critical molecules for the function and survival of neurons that degenerate during the course of AD. In this review we summarize the evidence for the involvement of NPY and neurotrophins in AD pathogenesis, and the similarity between them in CNS neurons. Finally, we recapitulate our recent in-vitro evidence for the involvement of neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the neuroprotective effect elicited by NPY in AD neuron-like models (neuroblastoma cells or primary cultures exposed to toxic concentrations of Aβ’s pathogenic fragment 25–35), and propose a putative mechanism based on NPY-induced inhibition of voltage-dependent Ca2+ influx in pre- and post-synaptic neurons.
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| 4. |
- Croce, N, et al.
(författare)
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Effects of lithium and valproic acid on BDNF protein and gene expression in an in vitro human neuron-like model of degeneration
- 2014
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Ingår i: Journal of psychopharmacology (Oxford, England). - : SAGE Publications. - 1461-7285 .- 0269-8811. ; 28:10, s. 964-972
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Tidskriftsartikel (refereegranskat)abstract
- One of the common effects of lithium (Li) and valproic acid (VPA) is their ability to protect against excitotoxic insults. Neurodegenerative and neuropsychiatric diseases may be also associated with altered trophic support of brain-derived neurotrophic factor (BDNF), the most widely distributed neurotrophin in the central nervous system. However, despite these evidences, the effect of Li–VPA combination on BDNF after excitoxic insult has been inadequately investigated. We address this issue by exposing a human neuroblastoma cell line (SH-SY5Y) to neurotoxic concentration of L-glutamate and exploring whether the neuroprotective action of Li–VPA on these cells is associated with changes in BDNF protein and mRNA levels. The results showed that pre-incubation of Li–VPA abolished the toxic effect of glutamate on SH-SY5Y cell survival and this neuroprotective effect was associated with increased synthesis and mRNA expression of BDNF after 24 and 48 h of incubation. In conclusion, this study demonstrates that the neuroprotective effects of Li-VPA against glutamate-induced neurotoxicity in SH-SY5Y neuroblastoma cells is associated with increased synthesis and mRNA expression of BDNF. These data further support the idea that these two drugs can be used for prevention and/or treatment of glutamate-related neurodegenerative disorders.
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| 7. |
- Maroni, F., et al.
(författare)
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Highly Stable Fe3O4/C Composite: A Candidate Material for All Solid-State Lithium-Ion Batteries
- 2020
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Ingår i: Journal of the Electrochemical Society. - : The Electrochemical Society. - 1945-7111 .- 0013-4651. ; 167:7
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Tidskriftsartikel (refereegranskat)abstract
- Fe3O4 nanoparticles synthesized by a base catalyzed method are tested in an All-Solid-State (ASLB) battery using a sulfide electrolyte. The pristine nanoparticles were morphologically characterized showing an average size of 12 nm. The evaluation of the electrochemical properties shows high specific capacity values of 506 mAhg(-1) after 350 cycles at a specific current of 250 mAg(-1), with very high stability and coulombic efficiency. (C) 2020 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited.
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| 8. |
- Maroni, Fabio, et al.
(författare)
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V2O5 Cryogel: A Versatile Electrode for All Solid State Lithium Batteries
- 2019
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Ingår i: Journal of the Electrochemical Society. - : The Electrochemical Society. - 1945-7111 .- 0013-4651. ; 166:16, s. A3927-A3931
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Tidskriftsartikel (refereegranskat)abstract
- All solid-state lithium batteries (ASLB) are paving the attention of the battery community due to the possibility of improving safety at good energy level. Their future development requires the investigation of new electrodes chemistries both based on intercalation or conversion mechanism. In this work we report on the synthesis and characterization of a V2O5 cryogel electrode and its application in ASLB. The combination of V2O5 cryogel and a solid-state electrolyte shows appealing properties of high capacity and enhanced safety.
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