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- David, J. C., et al.
(författare)
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Modeling astatine production in liquid lead-bismuth spallation targets
- 2013
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 49:3
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Tidskriftsartikel (refereegranskat)abstract
- Astatine isotopes can be produced in liquid lead-bismuth eutectic targets through proton-induced double charge exchange reactions on bismuth or in secondary helium-induced interactions. Models implemented into the most common high-energy transport codes generally have difficulties to correctly estimate their production yields as was shown recently by the ISOLDE Collaboration, which measured release rates from a lead-bismuth target irradiated by 1.4 and 1 GeV protons. In this paper, we first study the capability of the new version of the Liege intranuclear cascade model, INCL4.6, coupled to the de-excitation code ABLA07 to predict the different elementary reactions involved in the production of such isotopes through a detailed comparison of the model with the available experimental data from the literature. Although a few remaining deficiencies are identified, very satisfactory results are found, thanks in particular to improvements brought recently on the treatment of low-energy helium-induced reactions. The implementation of the models into MCNPX allows identifying the respective contributions of the different possible reaction channels in the ISOLDE case. Finally, the full simulation of the ISOLDE experiment is performed, taking into account the likely rather long diffusion time from the target, and compared with the measured diffusion rates for the different astatine isotopes, at the two studied energies, 1.4 and 1 GeV. The shape of the isotopic distribution is perfectly reproduced as well as the absolute release rates, assuming in the calculation a diffusion time between 5 and 10 hours. This work finally shows that our model, thanks to the attention paid to the emission of high-energy clusters and to low-energy cluster induced reactions, can be safely used within MCNPX to predict isotopes with a charge larger than that of the target by two units in spallation targets, and, probably, more generally to isotopes created in secondary reactions induced by composite particles.
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- Titarenko, Yu. E., et al.
(författare)
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Verification of high-energy transport codes on the basis of activation data
- 2011
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 84:6, s. 064612-
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Tidskriftsartikel (refereegranskat)abstract
- Nuclide production cross sections measured at the Institute for Theoretical and Experimental Physics (ITEP) for the targets of (nat)Cr, (56)Fe, (nat)Ni, (93)Nb, (181)Ta, (nat)W, (nat)Pb, and (209)Bi irradiated by protons with energies from 40 to 2600 MeV were used to estimate the predictive accuracy of several popular high-energy transport codes. A general agreement of the ITEP data with the data obtained by other groups, including the numerous GSI data measured by the inverse kinematics method was found. Simulations of the measured data were performed with the MCNPX (BERTINI and ISABEL options), CEM03.02, INCL4.2 + ABLA, INCL4.5 + ABLA07, PHITS, and CASCADE.07 codes. Deviation factors between the calculated and experimental cross sections have been estimated for each target and for the whole energy range covered by our measurements. Two-dimensional diagrams of deviation factor values were produced for estimating the predictive power of every code for intermediate, not measured masses of nuclei targets and bombarding energies of protons. Further improvements of all tested here codes are recommended. In addition, new measurements at ITEP of nuclide yields from the (208)Pb target irradiated by 500-MeV protons are presented. A good agreement between these new data and the GSI measurements obtained by the inverse kinematics method was found.
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| 5. |
- Arrizabalaga, O., et al.
(författare)
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High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response
- 2017
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Ingår i: Oncogenesis. - : Springer Science and Business Media LLC. - 2157-9024. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- The elucidation of mechanisms involved in resistance to therapies is essential to improve the survival of patients with malignant gliomas. A major feature possessed by glioma cells that may aid their ability to survive therapy and reconstitute tumors is the capacity for self-renewal. We show here that glioma stem cells (GSCs) express low levels of MKP1, a dual-specificity phosphatase, which acts as a negative inhibitor of JNK, ERK1/2, and p38 MAPK, while induction of high levels of MKP1 expression are associated with differentiation of GSC. Notably, we find that high levels of MKP1 correlate with a subset of glioblastoma patients with better prognosis and overall increased survival. Gain of expression studies demonstrated that elevated MKP1 impairs self-renewal and induces differentiation of GSCs while reducing tumorigenesis in vivo. Moreover, we identified that MKP1 is epigenetically regulated and that it mediates the anti-tumor activity of histone deacetylase inhibitors (HDACIs) alone or in combination with temozolomide. In summary, this study identifies MKP1 as a key modulator of the interplay between GSC self-renewal and differentiation and provides evidence that the activation of MKP1, through epigenetic regulation, might be a novel therapeutic strategy to overcome therapy resistance in glioblastoma.
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- Titarenko, Yu E., et al.
(författare)
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Measurement and simulation of the cross sections for nuclide production in Fe-56 and Cr-nat targets irradiated with 0.04- to 2.6-GeV protons
- 2011
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Ingår i: Physics of Atomic Nuclei. - 1063-7788 .- 1562-692X. ; 74:4, s. 523-536
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Tidskriftsartikel (refereegranskat)abstract
- The cross sections for nuclide production in thin Fe-56 and Cr-nat targets irradiated by 0.04-2.6-GeV protons are measured by direct gamma spectrometry using two gamma spectrometers with the resolutions of 1.8 and 1.7 keV for the Co-60 1332-keV gamma line. As a result, 649 yields of radioactive residual product nuclei have been obtained. The Al-27(p, x)Na-22 reaction has been used as a monitor reaction. The experimental data are compared with the MCNPX (BERTINI, ISABEL), CEM03.02, INCL4.2, INCL4.5, PHITS, and CASCADE07 calculations.
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- Titarenko, Yu E., et al.
(författare)
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Measurement and simulation of the cross sections for nuclide production in Nb-93 and Ni-nat targets irradiated with 0.04- to 2.6-GeV protons
- 2011
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Ingår i: Physics of Atomic Nuclei. - 1063-7788 .- 1562-692X. ; 74:4, s. 537-550
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Tidskriftsartikel (refereegranskat)abstract
- The cross sections for nuclide production in thin Nb-93 and Ni-nat targets irradiated by 0.04- to 2.6-GeV protons have been measured by direct gamma spectrometry using two gamma spectrometers with the resolutions of 1.8 and 1.7 keV in the Co-60 1332-keV gamma line. As a result, 1112 yields of radioactive residual nuclei have been obtained. The Al-27(p, x)Na-22 reaction has been used as a monitor reaction. The experimental data have been compared with the MCNPX (BERTINI, ISABEL), CEM03.02, INCL4.2, INCL4.5, PHITS, and CASCADE07 calculations.
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- Titarenko, Yu E., et al.
(författare)
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Measurement and simulation of the cross sections for nuclide production in W-nat and Ta-181 targets irradiated with 0.04- to 2.6-GeV protons
- 2011
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Ingår i: Physics of Atomic Nuclei. - 1063-7788 .- 1562-692X. ; 74:4, s. 551-572
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Tidskriftsartikel (refereegranskat)abstract
- The cross sections for nuclide production in thin (nat)Wand Ta-181 targets irradiated by 0.04-2.6-GeV protons have been measured by direct gamma spectrometry using two gamma spectrometers with the resolutions of 1.8 and 1.7 keV in the Co-60 1332-keV gamma line. As a result, 1895 yields of radioactive residual product nuclei have been obtained. The Al-27(p, x)Na-22 reaction has been used as a monitor reaction. The experimental data have been compared with the MCNPX (BERTINI, ISABEL), CEM03.02, INCL4.2, INCL4.5, PHITS, and CASCADE07 calculations.
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| 9. |
- Titarenko, Yu E., et al.
(författare)
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Measurement and simulation of the cross sections for the production of Gd-148 in thin W-nat and Ta-181 targets irradiated with 0.4- to 2.6-GeV protons
- 2011
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Ingår i: Physics of Atomic Nuclei. - 1063-7788 .- 1562-692X. ; 74:4, s. 573-579
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Tidskriftsartikel (refereegranskat)abstract
- The cross sections for the production of Gd-148 in W-nat and Ta-181 targets irradiated by 0.4-, 0.6-, 0.8-, 1.2-, 1.6-, and 2.6-GeV protons at the ITEP accelerator complex have been measured by direct alpha spectrometry without chemical separation. The experimental data have been compared with the data obtained at other laboratories and with the theoretical simulations of the yields on the basis of the BERTINI, ISABEL, CEM03.02, INCL4.2, INCL4.5, CASCADE07, and PHITS codes.
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