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Sökning: WFRF:(Cunin R)

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1.
  • Martin-Bernabe, A, et al. (författare)
  • Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia
  • 2021
  • Ingår i: International journal of molecular sciences. - : MDPI AG. - 1422-0067. ; 22:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Growing evidence is showing that acetylation plays an essential role in cancer, but studies on the impact of KDAC inhibition (KDACi) on the metabolic profile are still in their infancy. Here, we analyzed, by using an iTRAQ-based quantitative proteomics approach, the changes in the proteome of KRAS-mutated non-small cell lung cancer (NSCLC) A549 cells in response to trichostatin-A (TSA) and nicotinamide (NAM) under normoxia and hypoxia. Part of this response was further validated by molecular and biochemical analyses and correlated with the proliferation rates, apoptotic cell death, and activation of ROS scavenging mechanisms in opposition to the ROS production. Despite the differences among the KDAC inhibitors, up-regulation of glycolysis, TCA cycle, oxidative phosphorylation and fatty acid synthesis emerged as a common metabolic response underlying KDACi. We also observed that some of the KDACi effects at metabolic levels are enhanced under hypoxia. Furthermore, we used a drug repositioning machine learning approach to list candidate metabolic therapeutic agents for KRAS mutated NSCLC. Together, these results allow us to better understand the metabolic regulations underlying KDACi in NSCLC, taking into account the microenvironment of tumors related to hypoxia, and bring new insights for the future rational design of new therapies.
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2.
  • Varfolomeyev, S, et al. (författare)
  • Postgenomic chemistry (IUPAC Technical Report)
  • 2005
  • Ingår i: Pure and Applied Chemistry. - : Walter de Gruyter GmbH. - 0033-4545 .- 1365-3075. ; 77:9, s. 1641-1654
  • Tidskriftsartikel (refereegranskat)abstract
    • Numerous areas of chemistry can benefit from the ongoing genomic revolution. Here, we discuss and highlight trends in chemistry in the postgenomic era. The areas of interest include combinatorial approaches in organic chemistry; design and analysis of proteins containing unnatural amino acids; trace element-containing proteins; design and characterization of new enzyme types; applications of postgenomic chemistry in drug design; identification of lipid networks and global characterization of lipid molecular species; development of recombinant and self-proliferating polymers; and applications in food chemistry and bioanalytical chemistry based on new nanoanalytical systems and novel recognition elements.
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