| 1. |
- Block, Keith I., et al.
(författare)
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Designing a broad-spectrum integrative approach for cancer prevention and treatment
- 2015
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Ingår i: Seminars in Cancer Biology. - : Academic Press. - 1044-579X .- 1096-3650. ; 35, s. S276-S304
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Forskningsöversikt (refereegranskat)abstract
- Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broadspectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered. (C) 2015 The Authors. Published by Elsevier Ltd.
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| 2. |
- Falster, Daniel, et al.
(författare)
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AusTraits, a curated plant trait database for the Australian flora
- 2021
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Ingår i: Scientific Data. - : Nature Portfolio. - 2052-4463. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- We introduce the AusTraits database - a compilation of values of plant traits for taxa in the Australian flora (hereafter AusTraits). AusTraits synthesises data on 448 traits across 28,640 taxa from field campaigns, published literature, taxonomic monographs, and individual taxon descriptions. Traits vary in scope from physiological measures of performance (e.g. photosynthetic gas exchange, water-use efficiency) to morphological attributes (e.g. leaf area, seed mass, plant height) which link to aspects of ecological variation. AusTraits contains curated and harmonised individual- and species-level measurements coupled to, where available, contextual information on site properties and experimental conditions. This article provides information on version 3.0.2 of AusTraits which contains data for 997,808 trait-by-taxon combinations. We envision AusTraits as an ongoing collaborative initiative for easily archiving and sharing trait data, which also provides a template for other national or regional initiatives globally to fill persistent gaps in trait knowledge.
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| 3. |
- Giritli Nygren, Katarina, 1971-, et al.
(författare)
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Thoughts about intersectionality and risk. Interviews with key scholar
- 2024
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Ingår i: Journal of Risk Research. - : Routledge. - 1366-9877 .- 1466-4461.
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Tidskriftsartikel (refereegranskat)abstract
- Since the early twenty first century, feminist and intersectional approaches to risk research have gained momentum, initially emerging from studies on HIV risks within health studies. Over the past decade, these approaches have expanded to other fields. As editors of this special issue, Katarina Giritli Nygren and Anna Olofsson introduce a reflection piece anchoring the issue. The reflection piece includes insights from seven influential scholars in the intersectionality, equality, and risk fields: Lisa Bowleg, Dean Curran, Kelly Hannah Moffat, Claudia Mitchell, Lori Peek, Ignacio Rubio C., and Jens O. Zinn. Each scholar offers personal reflections on the development of intersectional analyses in risk research, highlighting key areas for future research. Three themes emerged: challenging risk as a neutral concept, addressing the complexity of risks in everyday life, and navigating between social structures and identity struggles. Contributors argue for contextualising risk within broader societal structures, embracing complexity, and understanding the intertwined nature of inequalities. Some, but not all, also advocate for intersectionality as a critical concept for studies of systemic change and equality. Overall, the reflections underscore the importance of centring intersectionality in understanding the dimensions of inequality and risk. The piece concludes by calling for further conversations and reflections to deepen our understanding of risk mobilisations and their links to inequality, both locally and globally. Such conversations can challenge assumptions and revitalize risk research, envisioning alternative worlds that prioritize equality.
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