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- Yang, Wen-Yi, et al.
(författare)
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Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes
- 2019
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Ingår i: Journal of the American Medical Association (JAMA). - : AMER MEDICAL ASSOC. - 0098-7484 .- 1538-3598. ; 322:5, s. 409-420
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Tidskriftsartikel (refereegranskat)abstract
- ImportanceBlood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal and nonfatal outcomes. It is uncertain which BP index is most strongly associated with these outcomes. ObjectiveTo evaluate the association of BP indexes with death and a composite CV event. Design, Setting, and ParticipantsLongitudinal population-based cohort study of 11135 adults from Europe, Asia, and South America with baseline observations collected from May 1988 to May 2010 (last follow-ups, August 2006-October 2016). ExposuresBlood pressure measured by an observer or an automated office machine; measured for 24 hours, during the day or the night; and the dipping ratio (nighttime divided by daytime readings). Main Outcomes and MeasuresMultivariable-adjusted hazard ratios (HRs) expressed the risk of death or a CV event associated with BP increments of 20/10 mm Hg. Cardiovascular events included CV mortality combined with nonfatal coronary events, heart failure, and stroke. Improvement in model performance was assessed by the change in the area under the curve (AUC). ResultsAmong 11135 participants (median age, 54.7 years, 49.3% women), 2836 participants died (18.5 per 1000 person-years) and 2049 (13.4 per 1000 person-years) experienced a CV event over a median of 13.8 years of follow-up. Both end points were significantly associated with all single systolic BP indexes (P<.001). For nighttime systolic BP level, the HR for total mortality was 1.23 (95% CI, 1.17-1.28) and for CV events, 1.36 (95% CI, 1.30-1.43). For the 24-hour systolic BP level, the HR for total mortality was 1.22 (95% CI, 1.16-1.28) and for CV events, 1.45 (95% CI, 1.37-1.54). With adjustment for any of the other systolic BP indexes, the associations of nighttime and 24-hour systolic BP with the primary outcomes remained statistically significant (HRs ranging from 1.17 [95% CI, 1.10-1.25] to 1.87 [95% CI, 1.62-2.16]). Base models that included single systolic BP indexes yielded an AUC of 0.83 for mortality and 0.84 for the CV outcomes. Adding 24-hour or nighttime systolic BP to base models that included other BP indexes resulted in incremental improvements in the AUC of 0.0013 to 0.0027 for mortality and 0.0031 to 0.0075 for the composite CV outcome. Adding any systolic BP index to models already including nighttime or 24-hour systolic BP did not significantly improve model performance. These findings were consistent for diastolic BP. Conclusions and RelevanceIn this population-based cohort study, higher 24-hour and nighttime blood pressure measurements were significantly associated with greater risks of death and a composite CV outcome, even after adjusting for other office-based or ambulatory blood pressure measurements. Thus, 24-hour and nighttime blood pressure may be considered optimal measurements for estimating CV risk, although statistically, model improvement compared with other blood pressure indexes was small.
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| 4. |
- Walker, M. J. C., et al.
(författare)
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Formal Subdivision of the Holocene Series/Epoch
- 2014
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Ingår i: STRATI 2013. - Cham : Springer International Publishing. - 2197-9545. - 9783319043630 ; , s. 983-987
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Konferensbidrag (refereegranskat)abstract
- This proposal, by a Working Group of Integration of ice-core, marine, and terrestrial records (INTIMATE) and the Subcommission on Quaternary Stratigraphy (SQS) of the International Commission on Stratigraphy (ICS), is for a formal subdivision of the Holocene Series/Epoch. Although previous attempts to subdivide the Holocene have proved inconclusive, recent developments in Quaternary stratigraphy, notably the definition of the Pleistocene-Holocene boundary and the emergence of formal subdivisions of the Pleistocene Series/Epoch, mean that it may be timely to revisit this matter. The Quaternary literature reveals a widespread but variable informal usage of a tripartite division of the Holocene ("early", "middle" or "mid-", and "late"), and we propose that this de facto subdivision should now be formalised to ensure consistency in stratigraphic terminology. We advocate a formal Early-Middle Holocene boundary at 8200 a BP and a formal Middle-Late Holocene boundary at 4200 a BP, each of which is linked to a Global Stratotype Section and Point (GSSP).
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| 5. |
- Walker, M. J. C., et al.
(författare)
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Formal subdivision of the Holocene Series/Epoch: a Discussion Paper by a Working Group of INTIMATE (Integration of ice-core, marine and terrestrial records) and the Subcommission on Quaternary Stratigraphy (International Commission on Stratigraphy)
- 2012
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Ingår i: Journal of Quaternary Science. - : Wiley. - 1099-1417 .- 0267-8179. ; 27:7, s. 649-659
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Forskningsöversikt (refereegranskat)abstract
- This discussion paper, by a Working Group of INTIMATE (Integration of ice-core, marine and terrestrial records) and the Subcommision on Quaternary Stratigraphy (SQS) of the International Commission on Stratigraphy (ICS), considers the prospects for a formal subdivision of the Holocene Series/Epoch. Although previous attempts to subdivide the Holocene have proved inconclusive, recent developments in Quaternary stratigraphy, notably the definition of the PleistoceneHolocene boundary and the emergence of formal subdivisions of the Pleistocene Series/Epoch, mean that it may be timely to revisit this matter. The Quaternary literature reveals a widespread but variable informal usage of a tripartite division of the Holocene (early, middle or mid, and late), and we argue that this de facto subdivision should now be formalized to ensure consistency in stratigraphic terminology. We propose an EarlyMiddle Holocene Boundary at 8200 a BP and a MiddleLate Holocene Boundary at 4200 a BP, each of which is linked to a Global Stratotype Section and Point (GSSP). Should the proposal find a broad measure of support from the Quaternary community, a submission will be made to the International Union of Geological Sciences (IUGS), via the SQS and the ICS, for formal ratification of this subdivision of the Holocene Series/Epoch. Copyright (C) 2012 John Wiley & Sons, Ltd.
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| 6. |
- Björck, S., et al.
(författare)
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An event stratigraphy for the Last Termination in the North Atlantic region based on the Greenland Ice-core record: a proposal by the INTIMATE group.
- 1998
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Ingår i: Journal of Quaternary Science. - 0267-8179 .- 1099-1417. ; 13:4, s. 283-292
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Tidskriftsartikel (refereegranskat)abstract
- It is suggested that the GRIP Greenland ice-core should constitute the stratotype for the Last Termination. Based on the oxygen isotope signal in that core, a new event stratigraphy spanning the time interval from ca. 22.0 to 11.5 k GRIP yr BP (ca. 19.0-10.0 k C-14 yr BP) is proposed for the North Atlantic region. This covers the period from the Last Glacial Maximum, through Termination 1 of the deep-ocean record, to the Pleistocene-Holocene boundary, and encompasses the Last Glacial Late-glacial of the traditional northwest European stratigraphy. The isotopic record for this period is divided into two stadial episodes, Greenland Stadials 1 (GS-1) and 2 (GS-2), and two interstadial events, Greenland Interstadials 1 (GI-1) and 2 (GI-2). In addition, GI-1 and GS-2 are further subdivided into shorter episodes. The event stratigraphy is equally applicable to ice-core, marine and terrestrial records and is considered to be a more appropriate classificatory scheme than the terrestrially based radiocarbon-dated chronostratigraphy that has been used hitherto.
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| 8. |
- Sundqvist, Hanna S., et al.
(författare)
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Arctic Holocene proxy climate database - new approaches to assessing geochronological accuracy and encoding climate variables
- 2014
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Ingår i: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 10:4, s. 1605-1631
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Tidskriftsartikel (refereegranskat)abstract
- We present a systematic compilation of previously published Holocene proxy climate records from the Arctic. We identified 170 sites from north of 58 degrees N latitude where proxy time series extend back at least to 6 cal ka (all ages in this article are in calendar years before present - BP), are resolved at submillennial scale (at least one value every 400 +/- 200 years) and have age models constrained by at least one age every 3000 years. In addition to conventional meta-data for each proxy record (location, proxy type, reference), we include two novel parameters that add functionality to the database. First, climate interpretation is a series of fields that logically describe the specific climate variable(s) represented by the proxy record. It encodes the proxy-climate relation reported by authors of the original studies into a structured format to facilitate comparison with climate model outputs. Second, geochronology accuracy score (chron score) is a numerical rating that reflects the overall accuracy of C-14-based age models from lake and marine sediments. Chron scores were calculated using the original author-reported C-14 ages, which are included in this database. The database contains 320 records (some sites include multiple records) from six regions covering the circumpolar Arctic: Fennoscandia is the most densely sampled region (31% of the records), whereas only five records from the Russian Arctic met the criteria for inclusion. The database contains proxy records from lake sediment (60 %), marine sediment (32 %), glacier ice (5 %), and other sources. Most (61 %) reflect temperature (mainly summer warmth) and are primarily based on pollen, chironomid, or diatom assemblages. Many (15 %) reflect some aspect of hydroclimate as inferred from changes in stable isotopes, pollen and diatom assemblages, humification index in peat, and changes in equilibrium-line altitude of glaciers. This comprehensive database can be used in future studies to investigate the spatio-temporal pattern of Arctic Holocene climate changes and their causes. The Arctic Holocene data set is available from NOAA Paleoclimatology.
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