| 1. |
- Adamo, Hanibal Hani, 1984-, et al.
(författare)
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Prostate cancer induces C/EBPβ expression in surrounding epithelial cells which relates to tumor aggressiveness and patient outcome
- 2019
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Ingår i: The Prostate. - : John Wiley & Sons. - 0270-4137 .- 1097-0045. ; 79:5, s. 435-445
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Tidskriftsartikel (refereegranskat)abstract
- Background: Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating adaptations in the tumor-bearing organ. Similar changes are seen in prostate cancer patients and they are related to outcome. One gene previously found to be upregulated in the non-malignant part of tumor-bearing prostate lobe in rats was the transcription factor CCAAT/enhancer-binding protein- (C/EBP).Methods: To explore this further, we examined C/EBP expression by quantitative RT-PCR, immunohistochemistry, and Western blot in normal rat prostate tissue surrounding slow-growing non-metastatic Dunning G, rapidly growing poorly metastatic (AT-1), and rapidly growing highly metastatic (MatLyLu) rat prostate tumors?and also by immunohistochemistry in a tissue microarray (TMA) from prostate cancer patients managed by watchful waiting.Results: In rats, C/EBP mRNA expression was upregulated in the surrounding tumor-bearing prostate lobe. In tumors and in the surrounding non-malignant prostate tissue, C/EBP was detected by immunohistochemistry in some epithelial cells and in infiltrating macrophages. The magnitude of glandular epithelial C/EBP expression in the tumor-bearing prostates was associated with tumor size, distance to the tumor, and metastatic capacity. In prostate cancer patients, high expression of C/EBP in glandular epithelial cells in the surrounding tumor-bearing tissue was associated with accumulation of M1 macrophages (iNOS+) and favorable outcome. High expression of C/EBP in tumor epithelial cells was associated with high Gleason score, high tumor cell proliferation, metastases, and poor outcome.Conclusions: This study suggest that the expression of C/EBP-beta, a transcription factor mediating multiple biological effects, is differentially expressed both in the benign parts of the tumor-bearing prostate and in prostate tumors, and that alterations in this may be related to patient outcome.
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| 2. |
- Adamo, Hanibal, et al.
(författare)
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Prostate cancer induces C/EBPβ expression in surrounding epithelial cells which relates to tumor aggressiveness and patient outcome
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating adaptations in the tumor-bearing organ. Similar changes are seen in prostate cancer patients and they are related to outcome. One gene previously found to be upregulated in the non-malignant part of a tumor-bearing prostate lobe in rats was the transcription factor CCAAT/enhancer-binding protein-β (C/EBPβ). To explore this further, we examined C/EBPβ expression by quantitative RT-PCR, immunohistochemistry, and western blot in normal rat prostate tissue surrounding slow-growing non-metastatic Dunning G, rapidly growing poorly metastatic (AT-1), and rapidly growing highly metastatic (MatLyLu) rat prostate tumors―and also by immunohistochemistry in a tissue microarray (TMA) from prostate cancer patients managed by watchful waiting.In rats, C/EBPβ mRNA expression was upregulated in the surrounding tumor-bearing prostate lobe. In tumors and in the surrounding non-malignant prostate tissue, C/EBPβ was detected by immunohistochemistry in some epithelial cells and in infiltrating macrophages. The magnitude of glandular epithelial C/EBPβ expression in the tumor-bearing prostates was associated with tumor size, with distance to the tumor, and with tumor cell metastatic capacity.In prostate cancer patients, high expression of C/EBPβ in glandular epithelial cells in the surrounding tumor-bearing tissue was associated with accumulation of M1 macrophages (iNOS+) and a favorable outcome. High expression of C/EBPβ in tumor epithelial cells was associated with high Gleason score, high tumor cell proliferation, the presence of metastases at diagnosis, and poor outcome.
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| 3. |
- Bresin, Roberto, et al.
(författare)
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The Radio Baton as configurable musical instrument and controller
- 2003
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Ingår i: Proc. Stockholm Music Acoustics Conference. ; , s. 689-691
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Konferensbidrag (refereegranskat)abstract
- The Max Mathews radio baton (RB) has been produced in about 40 pieces until today. It has usually been applied as an orchestra conducting system, as interactive music composition controller using typical percussionist gestures, and as a controller for sound synthesis models. In the framework of the Sounding Object EU founded project, the RB has found new applications scenarios. Three applications were based on this controller. This was achieved by changing the gesture controls. Instead of the default batons, a new radio sender that fits the fingertips was developed. This new radio sender allows musicians’ interaction based on hand gestures and it can also fit different devices. A Pd model of DJ scratching techniques (submitted to SMAC03) was controlled with the RB and the fingertip radio sender. This controller allows DJs a direct control of sampled sounds maintaining hand gestures similar to those used on vinyl. The sound model of a bodhran (submitted to SMAC03) was controlled with a traditional playing approach. The RB was controlled with a traditional bodhran double beater with one fingertip radio sender at each end. This allowed detection of the beater position on the RB surface, the surfaced corresponding to the membrane in the sound model. In a third application the fingertip controller was used to move a virtual ball rolling along the elastic surface of a box placed over the surface of the RB. The DJ console and the virtual bodhran were played in concerts.
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| 4. |
- Bresin, Roberto, et al.
(författare)
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Toward a new model for sound control
- 2001
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Ingår i: Proceedings of the COST G-6 Conference on Digital Audio Effects (DAFX-01), Limerick, Ireland, December 6-8, 200. ; , s. 45-49
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Konferensbidrag (refereegranskat)abstract
- The control of sound synthesis is a well-known problem. This is particularly true if the sounds are generated with physical modeling techniques that typically need specification of numerous control parameters. In the present work outcomes from studies on automatic music performance are used for tackling this problem.
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| 5. |
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| 6. |
- Dahl, Sofia, et al.
(författare)
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Aquatic foodweb modelling of Lake Vättern, Sweden
- 2004
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The potential of ancient DNA research is far reaching in evolutionary studies and offers many opportunities, several of which have been little explored in plant palaeoecology. Recent genetic studies of fossil pollen of Scots pine retrieved from postglacial lake sediments in Sweden showed that chloroplast DNA can be recovered and used from remains as old as 10 ka. By sequencing and comparing short, yet very informative, chloroplast DNA regions from fossil and modern specimens we can now read the evolutionary message inscribed in this genome and learn how specific regions have evolved after the last glaciation. Can this approach be used also to study the evolutionary changes occurred both in time and space in plant populations during the last glaciation?
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| 7. |
- Dahl, Sofia, et al.
(författare)
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Expressiveness of a marimba player’s body movements
- 2004
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Ingår i: TMH-QPSR. - 1104-5787. ; 46:1, s. 075-086
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Musicians often make gestures and move their bodies expressing their musical intention. This visual information provides a separate channel of communication to the listener. In order to explore to what extent emotional intentions can be conveyed through musicians’ movements, video recordings were made of a marimba player performing the same piece with four different intentions, Happy, Sad, Angry and Fearful. Twenty subjects were asked to rate the silent video clips with respect to perceived emotional content and movement qualities. The video clips were presented in different viewing conditions, showing different parts of the player. The results showed that the intentions Happiness, Sadness and Anger were well communicated, while Fear was not. The identification of the intended emotion was only slightly influenced by viewing condition. The movement ratings indicated that there were cues that the observers used to distinguish between intentions, similar to cues found for audio signals in music performance.
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| 8. |
- Dahl, Sofia, et al.
(författare)
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Expressiveness of musician's body movements in performances on marimba
- 2004
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Ingår i: Gesture-Based Communication in Human-Computer Interaction. - Genoa : Springer Verlag. ; , s. 479-486
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Konferensbidrag (refereegranskat)abstract
- To explore to what extent emotional intentions can be conveyed through musicians’ movements, video recordings were made of amarimba player performing the same piece with the intentions Happy, Sad, Angry and Fearful. 20 subjects were presented video clips, without sound, and asked to rate both the perceived emotional content as well as the movement qualities. The video clips were presented in different conditions, showing the player to different extent. The observers’ ratings forthe intended emotions confirmed that the intentions Happiness, Sadness and Anger were well communicated, while Fear was not. Identification of the intended emotion was only slightly influenced by the viewing condition. The movement ratings indicated that there were cues that the observers used to distinguish between intentions, similar to cues found for audio signals in music performance.
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| 9. |
- Dahl, Sofia, et al.
(författare)
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Gestures in performance
- 2009
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Ingår i: Musical Gestures: Sound, Movement, and Meaning. - New York : Routledge. - 9780415998871 - 0415998875 ; , s. 36-68
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Bokkapitel (refereegranskat)abstract
- We experience and understand the world, including music, through body movement–when we hear something, we are able to make sense of it by relating it to our body movements, or form an image in our minds of body movements. Musical Gestures is a collection of essays that explore the relationship between sound and movement. It takes an interdisciplinary approach to the fundamental issues of this subject, drawing on ideas, theories and methods from disciplines such as musicology, music perception, human movement science, cognitive psychology, and computer science.
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| 10. |
- Dahl, Sofia, et al.
(författare)
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Keeping the tempo and perceiving the beat
- 2006
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Ingår i: 9th International Conference on Music Perception and Cognition. - 8873951554
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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