| 1. |
- Aler Tubella, Andrea, 1990-, et al.
(författare)
-
ACROCPoLis : a descriptive framework for making sense of fairness
- 2023
-
Ingår i: FAccT '23. - : ACM Digital Library. - 9781450372527 ; , s. 1014-1025
-
Konferensbidrag (refereegranskat)abstract
- Fairness is central to the ethical and responsible development and use of AI systems, with a large number of frameworks and formal notions of algorithmic fairness being available. However, many of the fairness solutions proposed revolve around technical considerations and not the needs of and consequences for the most impacted communities. We therefore want to take the focus away from definitions and allow for the inclusion of societal and relational aspects to represent how the effects of AI systems impact and are experienced by individuals and social groups. In this paper, we do this by means of proposing the ACROCPoLis framework to represent allocation processes with a modeling emphasis on fairness aspects. The framework provides a shared vocabulary in which the factors relevant to fairness assessments for different situations and procedures are made explicit, as well as their interrelationships. This enables us to compare analogous situations, to highlight the differences in dissimilar situations, and to capture differing interpretations of the same situation by different stakeholders.
|
|
| 2. |
- Björstad, Åse, 1976, et al.
(författare)
-
Antimicrobial host defence peptides of human neutrophils – roles in innate immunity
- 2008
-
Ingår i: Anti-Infective Agents in Medicinal Chemistry. - : Bentham Science Publishers Ltd.. - 1871-5214. ; 7:3, s. 155-168
-
Forskningsöversikt (refereegranskat)abstract
- The innate immune system is an old defence mechanism that in primitive organisms consists mainly of humoral components like antimicrobial peptides. Many of these peptides share features such as size, cationicity, amphipathicity and kill microbes primarily by lysing the cell membrane. In more evolved organisms, humoral factors are supplemented by cellular components such as professional phagocytes, but the antimicrobial peptides are still important for host defence. Neutrophils are professional phagocytes that in humans contain two different classes of classical antimicrobial peptides belonging to the cathelicidin family and the α-defensin family, respectively. In addition to these two main groups of poly-peptides, neutrophils are also rich in antimicrobial proteins. It is becoming increasingly clear that the antimicrobial peptides of neutrophils not only contribute to phagosomal killing, but also function as regulators of immunity; therefore the alternative name host defence peptides is more appropriate. The question whether antimicrobial host defence peptides are primarily immunomodulatory or antimicrobial in vivo has not been conclusively determined. At some locations in the body, e.g. in a phagosome, their effect is likely directly antimicrobial, whereas their immunomodulatory functions are probably more important at other sites. This review will provide a background to the field of antimicrobial peptides including their common features, mechanisms of killing and availability in nature. It will focus on the antimicrobial peptides present in human neutrophils and special emphasis will be given to the functional dualism displayed by many peptides giving them the ability to modulate the immune response in addition to being directly antimicrobial
|
|
| 3. |
- Björstad, Åse, 1976, et al.
(författare)
-
Interleukin-8-derived peptide has antibacterial activity
- 2005
-
Ingår i: Antimicrobial agents and chemotherapy. - 0066-4804. ; 49:9, s. 3889-95
-
Tidskriftsartikel (refereegranskat)abstract
- Chemokines are inflammatory mediators with effects on diverse processes associated with the immune response. Some of the proteins belonging to the CXC chemokine subfamily, one of four groups in the family, possess inherent antibacterial activity against a wide range of bacteria. The CXC chemokine interleukin-8 (IL-8) has not been ascribed any direct antibacterial activity, but the fact that several of the amino acids in the carboxy-terminal part of the protein are identical or similar to those in a bactericidal cecropin-like peptide [Hp(2-20)] from Helicobacter pylori suggests that processing of the cytokine might generate peptide fragments with antibacterial properties. Synthetic peptides representing the carboxy-terminal part of IL-8 were investigated for antibacterial activities. These fragments possessed an antibacterial activity absent in the full-length IL-8. The antibacterial effects were reduced at increasing salt concentrations whereas the activity was increased when the pH was lowered. The IL-8-derived peptide shared structural similarity with and was also functionally additive to the Hp(2-20) peptide. The IL-8-derived peptide lacked the proinflammatory effects of the full-length protein. We also showed that acid hydrolysis of IL-8 generated a major peptide fragment corresponding to the antibacterial carboxyl terminus of the protein. The results presented are of special interest when put in the context of the suggested importance of antimicrobial peptides for microbial colonization of the gastric mucosa.
|
|
| 4. |
- Brown, M., et al.
(författare)
-
The impact of shift patterns on junior doctors' perceptions of fatigue, training, work/life balance and the role of social support
- 2010
-
Ingår i: Quality and Safety in Health Care. - : BMJ. - 1475-3898 .- 1470-7934. ; 19:6
-
Tidskriftsartikel (refereegranskat)abstract
- Background The organisation of junior doctors' work hours has been radically altered following the partial implementation of the European Working Time Directive. Poorly designed shift schedules cause excessive disruption to shift workers' circadian rhythms. Method Interviews and focus groups were used to explore perceptions among junior doctors and hospital managers regarding the impact of the European Working Time Directive on patient care and doctors' well-being. Results Four main themes were identified. Under "Doctors shift rotas", doctors deliberated the merits and demerits of working seven nights in row. They also discussed the impact on fatigue of long sequences of day shifts. "Education and training" focused on concerns about reduced on-the-job learning opportunities under the new working time arrangements and also about the difficulties of finding time and energy to study. "Work/life balance" reflected the conflict between the positive aspects of working on-call or at night and the impact on life outside work. "Social support structures" focused on the role of morale and team spirit. Good support structures in the work place counteracted and compensated for the effects of negative role stressors, and arduous and unsocial work schedules. Conclusions The impact of junior doctors' work schedules is influenced by the nature of specific shift sequences, educational considerations, issues of work/life balance and by social support systems. Poorly designed shift rotas can have negative impacts on junior doctors' professional performance and educational training, with implications for clinical practice, patient care and the welfare of junior doctors.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Forsman, Huamei, et al.
(författare)
-
The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist
- 2008
-
Ingår i: Glycobiology. - : Oxford University Press (OUP). - 1460-2423 .- 0959-6658. ; 18:11, s. 905-12
-
Tidskriftsartikel (refereegranskat)abstract
- Neutrophils interacting with a chemoattractant gradually become nonresponsive to further stimulation by the same agonist, a process known as desensitization. Receptor desensitization is a highly regulated process that involves different mechanisms depending on which receptor-ligand pair that is studied. Galectin-3, a member of a large family of beta-galactoside-binding lectins, has been suggested to be a regulator of the inflammatory process, augmenting or directly triggering the neutrophil functional repertoire. We show here that the desensitized state of neutrophils interacting with the chemotactic peptide fMLF is broken by galectin-3 and that this is achieved through an oxygen radical-mediated inactivation of the chemoattractant. The effect was inhibited by the competitor lactose and required the affinity of galectin-3 for N-acetyllactosamine, a saccharide typically found on cell surface glycoproteins. The latter was shown using a galectin-3 mutant that lacked N-acetyllactosamine binding activity, and this protein was not active. The mechanism behind the inactivation of the chemoattractant was found to depend on the ability of galectin-3 to induce a neutrophil generation/secretion of reactive oxygen species which in combined action with myeloperoxidase inactivated the peptides.
|
|
| 8. |
|
|
| 9. |
- Granfeldt, Daniel, 1974, et al.
(författare)
-
Neutrophil Secretion Induced by an Intracellular Ca(2+) Rise and Followed by Whole-Cell Patch-Clamp Recordings Occurs Without any Selective Mobilization of Different Granule Populations
- 2006
-
Ingår i: Journal of biomedicine & biotechnology. - 1110-7243. ; 2006:2, s. 97803-97803
-
Tidskriftsartikel (refereegranskat)abstract
- We have investigated calcium-induced secretion in human neutrophils, using a whole-cell patch-clamp technique. Mobilization of subcellular granules to the cell membrane was followed as the change in membrane capacitance ( big up tri, openC(m)). Both the magnitude and the kinetics of the response differed between low and high concentrations of Ca(2+). A sustained secretion following a short lag phase was induced by high concentrations of Ca(2+) (100muM and higher). A stable plateau was reached after 5-7 minutes at big up tri, openC(m) values corresponding to values expected after all specific as well as azurophil granules have been mobilized. Capacitance values of the same magnitude could be obtained also at lower Ca(2+) concentrations, but typically no stable plateau was reached within the measuring time. In contrast to previous studies, we were unable to detect any pattern of secretion corresponding to a distinct submaximal response or selective mobilization of granule subsets specified by their Ca(2+)-sensitivity.
|
|
| 10. |
- Hagsand, Angelica, 1985, et al.
(författare)
-
Effect of the degree of alcohol intoxication on eyewitness memory for a violent crime: Identification accuracy in lineup
- 2011
-
Ingår i: Oral presentation at The Nordic Network for Psychology and Law (NNPL), September 16-17 2011, Oslo, Norway.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Introduction and Aim. In Sweden, 50-70% of all violent crimes are alcohol related (BRÅ, 2007, 2009). Eyewitnesses are valuable to the Police since they have seen the event and many crimes lack technical evidence like DNA. Due to the limited studies in the area, this ongoing experimental study might give valuable knowledge to the legal system concerning the assessment of alcohol intoxicated eyewitnesses and the credibility of their testimonies. Methods. The participants (N = 120 when finished) consists of healthy adult students. The study uses a 3 x 2 between- participants design with random assignment to alcohol beverage (none vs. moderate vs. high dose,) and lineup presentation (target present vs. target absent). Consumption time is 15 minutes in a laboratory with living room design. A movie depicting a staged kidnapping is shown to the participants and after 30 minutes of distracting filler tasks the participants are interviewed. One week later, the participants are presented the simultaneous lineup in order to identify the culprit from the movie and are also interviewed in more detail about the crime scene. Results and Conclusions. The data collection is ongoing during the spring of 2011. To this date, data from half of the participants has been collected. Results concerning identification accuracy will be presented and discussed at the NNPL conference in Oslo in September 2011.
|
|
