| 1. |
- Forslund, Maria, 1978, et al.
(författare)
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Health-Related Quality of Life in perimenopausal women with PCOS
- 2022
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Ingår i: Clinical and Experimental Obstetrics and Gynecology. - : IMR Press. - 0390-6663. ; 49:2
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Tidskriftsartikel (refereegranskat)abstract
- Background: Several studies have shown that younger women with polycystic ovary syndrome (PCOS) have decreased Health-Related Quality of Life (HRQoL) compared with women in general. Method: In this study peri- and postmenopausal women previously diagnosed with PCOS (n = 27) were compared with randomly selected, age-matched controls (n = 94). Mean age of the study participants was 52 years. Structured interviews and Short Form (SF)-36 questionnaires were used. Results: No differences in SF-36 scores were found, median for the physical summary score was 54 vs. 57, for women with PCOS and controls, respectively; and 53 vs. 53 for the mental summary score, with no differences in any of the eight dimensions of HRQoL. There were no significant difference in prevalence of depression and/or anxiety. The use of drugs for mood disorders was 22% in both groups. Conclusion: PCOS women of peri- and postmenopausal ages had similar HRQoL compared with age-matched controls.
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| 2. |
- Forslund, Maria, 1978, et al.
(författare)
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Higher menopausal age but no differences in parity in women with polycystic ovary syndrome compared with controls.
- 2019
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Ingår i: Acta obstetricia et gynecologica Scandinavica. - : Wiley. - 1600-0412 .- 0001-6349. ; 98:3, s. 320-326
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Tidskriftsartikel (refereegranskat)abstract
- To address the question of whether women with polycystic ovary syndrome (PCOS) reach menopause later than age-matched controls, we conducted a follow-up cohort study of women with well-characterized PCOS that was diagnosed 24years ago. The hypothesis was that women with PCOS would reach menopause later than non-PCOS women. Parity during these 24years was also studied.Twenty-seven women diagnosed with PCOS in 1992 (mean age 29.5years) were re-examined in 2016 (mean age 52.4years). Randomly selected women, n =94 (mean age 52.4years), from the same geographic area included in the World Health Organization MONICA study, Gothenburg, Sweden, served as controls.The mean menopausal age in women with PCOS was higher than in controls (53.3±2.2years vs 49.3±3.5years, P<0.01). Serum-follicle stimulating hormone levels were lower in the PCOS women than in controls (31.0±28.1IU/L vs 52.3±37.7IU/L, P=0.01). There was no difference in parity between women with PCOS (1.9±1.3 children, range 0-4) and controls (1.7±1.0, range 0-4 children).Women with PCOS reached menopause 4years later and had lower serum-follicle stimulating hormone compared with age-matched controls. Neither parity nor nulliparity differed between women with PCOS and controls.
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| 3. |
- Forslund, Maria, 1978, et al.
(författare)
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Reproductive hormones and anthropometry: a follow-up of PCOS and controls from perimenopause to above 80 years of age.
- 2021
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 106:2, s. 421-430
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Tidskriftsartikel (refereegranskat)abstract
- There is a lack of knowledge about hormonal and anthropometric changes in women with polycystic ovary syndrome (PCOS) after the menopause.To study reproductive hormones and anthropometry in women with PCOS up to an age above 80 years.Prospective cohort study.University Hospital.A well-defined cohort of women with PCOS, previously examined in 1987 and 2008 (21 years period) was re-examined in 2019 (11 years period). Of the original cohort (n = 37), 22 women were still alive and 21 (age range 72-91 years) participated. Comparisons were made with age-matched controls (n = 55) from the original control cohort (BMI similar to PCOS women). The results were compared with results from 1987 and 2008.Hormonal measurements and physical examination.FSH, LH, testosterone, SHBG, free androgen index (FAI), hirsutism score, BMI, and waist-hip ratio (WHR).At mean age 81 years, FSH levels were lower in women with PCOS (50 vs. 70 IU/L) who were still more hirsute than controls (33% vs. 4%). No differences were found in FAI, testosterone, SHBG or LH levels, BMI or WHR.From perimenopausal age until the present age, levels of testosterone and FAI continued to decline in women with PCOS. SHBG levels continued to increase with age. FSH had not changed over time during the last eleven years.Women with PCOS at ages 72-91 had lower FSH levels, remained clinically hyperandrogenic and had similar FAI and body composition as controls.
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| 4. |
- Forslund, Maria, 1978, et al.
(författare)
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Type 2 diabetes mellitus in women with polycystic ovary syndrome during a 24-year period: importance of obesity and abdominal fat distribution.
- 2020
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Ingår i: Human reproduction open. - : Oxford University Press (OUP). - 2399-3529. ; 2020:1
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Tidskriftsartikel (refereegranskat)abstract
- What are the predictive factors for later development of type 2 diabetes (T2DM) in women with polycystic ovary syndrome (PCOS)?Obesity and abdominal fat distribution in women with PCOS in the mid-fertile years were the major risk factors for T2DM development 24years later when lifestyle factors were similar to controls.Women with PCOS have an increased prevalence of T2DM.A longitudinal and cross-sectional study was performed. Women with PCOS were examined in 1992 and in 2016. Randomly selected, age-matched women from the general population served as controls.Women with PCOS (n=27), attending an outpatient clinical at a tertiary care centre for infertility or hirsutism were diagnosed in 1992 (mean age 30years) and re-examined in 2016 (mean age 52years). Women from the World Health Organization MONItoring of trends and determinants for CArdiovascular disease (WHO MONICA-GOT) 2008, aged 38-68years, served as controls (n=94), and they were previously examined in 1995. At both at baseline and at follow-up, women had blood samples taken, underwent a clinical examination and completed structured questionnaires, and the women with PCOS also underwent a glucose clamp test at baseline.None of women with PCOS had T2DM at baseline. At the 24-year follow-up, 19% of women with PCOS had T2DM versus 1% of controls (P<0.01). All women with PCOS who developed T2DM were obese and had waist-hip ratio (WHR) >0.85 at baseline. No difference was seen between women with PCOS and controls regarding use of high-fat diet, Mediterranean diet or amount of physical activity at follow-up at peri/postmenopausal age. However, women with PCOS had a lower usage of a high-sugar diet as compared to controls (P=0.01). The mean increases in BMI and WHR per year were similar in women with PCOS and controls during the follow-up period.The small sample size of women with PCOS and the fact that they were recruited due to infertility or hirsutism make generalization to women with milder forms of PCOS uncertain.Obesity and abdominal fat distribution, but not hyperandrogenism per se, in women with PCOS in the mid-fertile years were the major risk factors for T2DM development 24years later when peri/postmenopausal. Lifestyle factors were similar to controls at that time.The study was financed by grants from the Swedish state under the agreement between the Swedish government and the country councils, the ALF-agreement (ALFGBG-718611), the Gothenburg Medical Association GLS 694291 and 780821, the Swedish Heart Lung Foundation and Hjalmar Svensson Foundation. The authors have no conflict of interest.
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| 5. |
- Åstrand, Per, 1935-, et al.
(författare)
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Astra Tech and Brånemark system implants: a 5-year prospective study of marginal bone reactions.
- 2004
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Ingår i: Clinical oral implants research. - : Wiley. - 0905-7161 .- 1600-0501. ; 15:4, s. 413-20
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the 5-year results of a comparative study between Astra Tech and Brånemark system implants. The aim was to compare the systems primarily with regard to bone level changes, and also with regard to other variables of interest. Sixty-six patients with edentulous jaws were included in the study. Randomisation schedules were used to allocate the patients to the two implant systems. 184 Astra Tech implants with a titanium-blasted surface and 187 Brånemark implants with a turned surface were used. The implants were inserted with a two-stage technique and the insertion followed the routines for the respective implant system. All patients were provided with full-arch fixed bridges. All patients were followed up with clinical and radiographic examinations from fixture insertion to the 5-year follow-up. The total mean bone level change in the upper jaw between fixture insertion and the 5-year examination was -1.74+/-0.45 mm at the Astra implants and -1.98+/-0.21 at the Brånemark implants. The corresponding values for the lower jaw were -1.06+/-0.19 for Astra and -1.38+/-0.17 for Brånemark. The major postoperative changes of the marginal bone level took place between fixture insertion and baseline. During this period, there was also a different pattern of bone remodelling between the implant systems. Between baseline (prosthesis connection) and the 5-year examination, the marginal bone level changes were small, with no difference between the implant systems. The implant stability was examined with the supraconstructions removed. At the 5-year examination, the survival rate for Astra Tech implants was 98.4% and for the Brånemark implants it was 94.6%. The difference was not statistically significant.
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