| 1. |
- Dahlgren, David, et al.
(författare)
-
Ulcerative colitis progression : a retrospective analysis of disease burden using electronic medical records
- 2022
-
Ingår i: Upsala Journal of Medical Sciences. - : Upsala Medical Society. - 0300-9734 .- 2000-1967. ; 127:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Ulcerative colitis (UC) is a debilitating inflammatory bowel disease. Present knowledge regarding UC disease progression over time is limited.Objective: To assess UC progression to severe disease along with disease burden and associated factors.Methods: Electronic medical records linked with Swedish national health registries (2005-2015) were used to identify disease progression of UC. Odds of all-cause and disease-related hospitalization within 1 year were compared between patients with disease progression and those without. Annual indirect costs were calculated based on sick leave, and factors related to UC progression were examined.Results: Of the 1,361 patients with moderate UC, 24% progressed to severe disease during a median of 5.2 years. Severe UC had significantly higher odds for all-cause (OR [odds ratio] 1.47, 95% CI [confidence interval]: 1.12-1.94, P < 0.01) and UC-related hospitalization (OR 2.47, 95% CI: 1.76-3.47, P < 0.0001) compared to moderate disease. Average sick leave was higher in patients who progressed compared to those who did not (64.4 vs 38.6 days, P < 0.001), with higher indirect costs of 151,800 SEK (16,415 ) pound compared with 92,839 SEK (10,039 ) pound (P < 0.001), respectively. UC progression was related to young age (OR 1.62, 95% CI: 1.17-2.25, P < 0.01), long disease duration (OR 1.09, 95% CI: 1.03-1.15, P < 0.001), and use of corticosteroids (OR 2.49, 95% CI: 1.67-3.72, P < 0.001).Conclusion: Disease progression from moderate to severe UC is associated with more frequent and longer hospitalizations and sick leave. Patients at young age with long disease duration and more frequent gluco-corticosteroid medication are associated with progression to severe UC.
|
|
| 2. |
- Dahlgren, E., et al.
(författare)
-
A screening study of relationships among concentrations of algal toxins, PFAS, thiamine deficiency and biomarkers in the European flounder from the southern Baltic Sea
- 2022
-
Ingår i: Regional Studies in Marine Science. - : Elsevier BV. - 2352-4855. ; 53
-
Tidskriftsartikel (refereegranskat)abstract
- In the disturbed Baltic Sea ecosystem, several animal species display failing health related to exposure to toxic compounds, reduced energy metabolism and immune system disorders. In order to investigate possible associations between fish health and exposure to chemicals affecting the energy metabolism and immune defence, the levels of algal toxins (bromophenols, hydroxylated polybrominated diphenyl ethers and nodularin), perfluorinated alkyl substances (PFAS) and thiamine (vitamin B1) were determined in European flounder (Platichthys flesus). Several biomarkers indicating health status were examined in the fish, including ethoxyresorufin-O-deethylase (EROD), and activities of glutathione reductase, glutathione S-transferase and catalase, in addition to a large set of blood variables. The fish were collected from Hanobukten in the south-western parts of the Baltic Sea in late August 2018. Regression analyses of algal toxins, PFAS and thiamine concentration displayed several significant associations with biomarkers associated with detoxification and liver function, immune system function and blood status of the fish. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
|
|
| 3. |
|
|
| 4. |
- Rudman, Ann, et al.
(författare)
-
Sjuksköterskor i frontlinjen av COVID-19 pandemin : vilka blev konsekvenserna? Teknisk rapport om enkät och datainsamling
- 2022
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport summerar datainsamlingen som genomfördes av SCB (Statistiska centralbyrån) i projektet ”Sjuksköterskor i frontlinjen av COVID-19 pandemin: Vilka blev konsekvenserna?”. Projektet är finansierat av AFA försäkring (Diarienr 200311). I kapitel 1 beskrivs bakgrund till LUST (Longitudinell Undersökning om Sjuksköterskors Tillvaro) studien. I kapitel 2 beskrivs studien utifrån design, rekrytering och datainsamling. I kapitel 3 redovisas översikt över innehållet i enkäten som skickades ut studiedeltagarna. Projektet bedrivs på Högskolan Dalarna och inom ramen för Petter Gustavssons forskargrupp vid Karolinska Institutet.Sjuksköterskor har varit i frontlinjen av COVID-19-pandemin och de stressorer som de utsatts för i sitt arbete inom hälso- och sjukvården kan orsaka hälsoproblem. I föreliggande projekt har en nationell kartläggning av sjuksköterskors arbetssituation och hälsa under COVID-19 pandemin gjorts. Undersökningen är gjord utifrån de tre sjuksköterskekohorter som följts inom ramen för LUST-studien sedan 2002 (Gustavsson et al., 2013; Rudman, Hörberg, et al., 2020; Rudman et al., 2010). I LUST-studien har närmare 4500 sjuksköterskestudenter följts med uppföljande enkäter från deras utbildningstid 11 till 15 år efter examen. En uppföljande enkätundersökning genomfördes i september 2021 till januari 2022 vilket motsvarar 15 till 19 år efter examen. En speciellt anpassad enkät med relevans och aktualitet för arbetet under pandemin hade utvecklats gemensamt med forskare som har expertis gällande sjuksköterskor i olika verksamheter som belastats under COVID-19 pandemin. Enkäterna besvarades när pandemin pågått i ungefär ett år och nio månader.I samarbete med SCB har datainsamlingen genomförts som en postenkät med påminnelser och med möjlighet att besvara frågorna online. Svarsfrekvensen för enkätstudien blev 57% för hela undersökningen (för samtliga kohorter), vilket bedöms vara en hög svarsfrekvens med tanke på hur belastad sjuksköterskekåren har varit under COVID-19 pandemin.
|
|
| 5. |
- Gustafsson, Johan, et al.
(författare)
-
Correlating seasonal changes of naturally produced brominated compounds to biomarkers in perch from the Baltic Sea
- 2021
-
Ingår i: Aquatic Toxicology. - : Elsevier BV. - 0166-445X .- 1879-1514. ; 240
-
Tidskriftsartikel (refereegranskat)abstract
- Hydroxylated polybrominated diphenyl ethers (OH-PBDEs), naturally produced by algae and cyanobacteria in the Baltic Sea, are potent disrupters of energy metabolism as well as endocrine disruptors and neurotoxins. In this study, European perch (Perca fluviatilis) from the Baltic Sea were sampled from May until October. OH-PBDEs and ten biomarkers were measured in each individual (n = 84 over 18 sampling time points) to study potential correlations between exposure to OH-PBDEs and changes in biomarkers. Several biomarkers showed significant non-linear seasonal variation. In the perch, ethoxyresorufin-O-deethylase (EROD) activity, plasma lactate concentration, and plasma glucose concentration showed a significant positive log-linear correlation with OH-PBDEs, whereas lipid percentage and liver somatic index showed a significant negative log-linear correlation with OH-PBDEs. These results strengthen the concern that OH-PBDEs could cause negative health effects for fish in the Baltic Sea.
|
|
| 6. |
|
|
| 7. |
- Baeten, Lander, et al.
(författare)
-
Identifying the tree species compositions that maximize ecosystem functioning in European forests
- 2019
-
Ingår i: Journal of Applied Ecology. - : Wiley. - 0021-8901 .- 1365-2664. ; 56:3, s. 733-744
-
Tidskriftsartikel (refereegranskat)abstract
- 1. Forest ecosystem functioning generally benefits from higher tree species richness, but variation within richness levels is typically large. This is mostly due to the contrasting performances of communities with different compositions. Evidence-based understanding of composition effects on forest productivity, as well as on multiple other functions will enable forest managers to focus on the selection of species that maximize functioning, rather than on diversity per se.2. We used a dataset of 30 ecosystem functions measured in stands with different species richness and composition in six European forest types. First, we quantified whether the compositions that maximize annual above-ground wood production (productivity) generally also fulfil the multiple other ecosystem functions (multifunctionality). Then, we quantified the species identity effects and strength of interspecific interactions to identify the "best" and "worst" species composition for multifunctionality. Finally, we evaluated the real-world frequency of occurrence of best and worst mixtures, using harmonized data from multiple national forest inventories.3. The most productive tree species combinations also tended to express relatively high multifunctionality, although we found a relatively wide range of compositions with high- or low-average multifunctionality for the same level of productivity. Monocultures were distributed among the highest as well as the lowest performing compositions. The variation in functioning between compositions was generally driven by differences in the performance of the component species and, to a lesser extent, by particular interspecific interactions. Finally, we found that the most frequent species compositions in inventory data were monospecific stands and that the most common compositions showed below-average multifunctionality and productivity.4. Synthesis and applications. Species identity and composition effects are essential to the development of high-performing production systems, for instance in forestry and agriculture. They therefore deserve great attention in the analysis and design of functional biodiversity studies if the aim is to inform ecosystem management. A management focus on tree productivity does not necessarily trade-off against other ecosystem functions; high productivity and multifunctionality can be combined with an informed selection of tree species and species combinations.
|
|
| 8. |
- Dahlgren, Lars Owe, 1946-, et al.
(författare)
-
Fenomenografi
- 2019. - 3
-
Ingår i: Handbok i kvalitativ analys. - Stockholm : Liber. - 9789147129706 ; , s. 179-192
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 9. |
|
|
| 10. |
- Flygare, Jonas, 1988, et al.
(författare)
-
Sensitivity simulation and measurement of the SKA Band 1 wideband feed package on MeerKAT
- 2019
-
Ingår i: 13th European Conference on Antennas and Propagation, EuCAP 2019. ; EuCAP 2019
-
Konferensbidrag (refereegranskat)abstract
- Advances in wideband feed technology for radio telescopes enable high sensitivity observations over large bandwidths. The wideband quad-ridge flared horn (QRFH) feed package for Band 1 of the Square Kilometre Array (SKA) was optimized for high sensitivity. The 3:1 feed package covers 350-1050 MHz and is a complete room temperature system with low-noise amplifiers integrated inside the ridges of the horn. The QRFH is dual-linear polarized and designed with spline-defined profiles for the horn and ridge shape. Measured feed s-parameters show input reflection less than -11 dB across the band with good port isolation. In this paper we present the first measured sensitivity levels of the Band 1 feed package, which was tested on the SKA precursor reflector MeerKAT. We also present measured aperture efficiency and intrinsic cross-polarization (IXR). The measured results show good agreement with simulations.
|
|
