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Sökning: WFRF:(Dahlquist M)

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  • Christie, M., et al. (författare)
  • Antibodies to a Mr-64000 islet cell protein in Swedish children with newly diagnosed Type 1 (insulin-dependent) diabetes
  • 1988
  • Ingår i: Diabetologia. - 0012-186X. ; 31:8, s. 597-602
  • Tidskriftsartikel (refereegranskat)abstract
    • Sera from 40 Swedish children diagnosed as having Type 1 (insulin-dependent) diabetes mellitus during a one year period along with 40 age and geographically matched control subjects were tested for antibodies to a Mr-64000 islet protein by immunoprecipitation of 35S-methionine-labelled rat islet amphiphilic proteins. Of the 40 diabetic patients, 29 (73%) were found to be positive whereas all 40 control subjects were negative. Samples were also tested for titres of islet cell cytoplasmic antibodies by indirect immunofluorescence on frozen sections of human pancreas. In the diabetic group, 30 of the 40 patients (75%) were positive for islet cell cytoplasmic antibodies compared with 2 of the 40 control subjects (5%). A comparison of levels of antibodies to the Mr-64000 protein with islet cell cytoplasmic antibodies revealed a weak (rs=0.46), but significant (p<0.01) correlation between the two tests. There was no effect of age or sex on levels of antibodies to the Mr-64000 protein. These results in population-based diabetic children and control subjects demonstrate a high frequency of antibodies to the Mr-64000 protein at the time of clinical onset.
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  • Dahlquist, M., et al. (författare)
  • Methodology for quantifying perceptual effects from noise suppression systems
  • 2005
  • Ingår i: International Journal of Audiology. - : Informa UK Limited. - 1499-2027 .- 1708-8186. ; 44:12, s. 721-732
  • Tidskriftsartikel (refereegranskat)abstract
    • Methodology is proposed for perceptual assessment of both subjective sound quality and speech recognition in such way that results can be compared between these two aspects, Validation is performed with a noise suppression system applied to hearing instruments. A method termed Interpolated Paired Comparison Rating (IPCR) was developed for time efficient assessment of subjective impression of different aspects of sound quality for a variety of noise conditions. The method is based on paired comparisons between processed and unprocessed stimuli, and the results are expressed as the difference in signal-to-noise ratio (dB) between these that give equal subjective impression. For tests of speech recognition in noise, validated adaptive test methods can be used that give results in terms of speech-to-noise ratio. The methodology was shown to be sensitive enough to detect significant mean differences between processed and unprocessed speech in noise, both regarding subjective sound quality and speech recognition ability in groups consisting of 30 subjects. An effect on sound quality from the noise suppression equivalent to about 3-4 dB is required to be statistically significant for a single subject. A corresponding effect of 3-6 dB is required for speech recognition (one-sided test). The magnitude of difference that occurred in the present study for sound quality was sufficient to show significant differences for sound quality within individuals, but this was not the case for speech recognition.
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