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Sökning: WFRF:(Dallner G)

  • Resultat 1-10 av 57
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  • APPELKVIST, EL, et al. (författare)
  • ISOPRENOID BIOSYNTHESIS IN PEROXISOMES
  • 1995
  • Ingår i: FASEB JOURNAL. - 0892-6638. ; 9:6, s. A1312-A1312
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Appelkvist, E L, et al. (författare)
  • Regulation of coenzyme Q biosynthesis
  • 1994
  • Ingår i: Molecular Aspects of Medicine. - 0098-2997 .- 1872-9452. ; 15:Suppl., s. 37-46
  • Forskningsöversikt (refereegranskat)abstract
    • The side-chain moiety of coenzyme Q is synthesized by a trans-prenyltransferase present in microsomes. Condensation of this moiety with the precursor ring takes place in the Golgi system. The enzymes involved, as well as the cytosolic geranylgeranyl-PP synthase, are regulated in an independent fashion. When the size of the farnesyl-PP pool is decreased or increased by employing appropriate inhibitors, the rate of CoQ synthesis is modified accordingly, indicating the dependence of trans-prenyltransferase activity on the level of intracellular substrate concentrations. Administration of peroxisome proliferators elevates CoQ concentrations not only in blood, but also in various tissues. Thus, it may be possible in the future to selectively increase CoQ concentrations in certain organs, without increasing the level of cholesterol.
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  • Appelkvist, E L, et al. (författare)
  • Synthesis of mevalonate pathway lipids in fibroblasts from Zellweger and X-linked ALD patients.
  • 1999
  • Ingår i: Pediatric Research. - : Springer Science and Business Media LLC. - 0031-3998 .- 1530-0447. ; 46:3, s. 345-50
  • Tidskriftsartikel (refereegranskat)abstract
    • Fibroblasts were cultured to determine the involvement of peroxisomes in cholesterol and dolichol synthesis. For this purpose, the behavior of cells from patients with Zellweger syndrome, with X-linked adrenoleukodystrophy, and from nondiseased control subjects was studied. Cells both after pretreatment with mevinolin and without pretreatment were incubated in a medium containing [3H]-mevalonate. In fibroblasts from patients with peroxisomal defects, the cholesterol content and mevalonate incorporation into cholesterol were decreased by 10-20% in comparison with control cells. Mevinolin pretreatment decreased the incorporation rate of [3H]-mevalonate into cholesterol but increased the labeling of ubiquinone and dolichol both in diseased and control cells. Squalene synthase activity was unchanged, whereas the activity of farnesyl-pyrophosphate synthase was increased in the diseased states. The results show that in patients with peroxisomal deficiency neither the amount nor the rate of synthesis of cholesterol and dolichol is reduced to any greater extent.
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  • Bentinger, M, et al. (författare)
  • The antioxidant role of coenzyme Q
  • 2007
  • Ingår i: Mitochondrion. - : Elsevier BV. - 1567-7249. ; 7, s. Suppl:S41-50
  • Tidskriftsartikel (refereegranskat)
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  • Resultat 1-10 av 57

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