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Numrering	Referens	Omslagsbild	Hitta
1.	Brånalt, J, et al. (författare) A convenient synthesis of 1-(S)-[1'-(S)-(t-butyloxycarbonylamino)-2'-phenylethyl]oxirane : a useful building block in the synthesis of HIV protease inhibitors 1997 Ingår i: Tetrahedron Letters. - : Elsevier. - 0040-4039 .- 1359-8562. ; 38:19, s. 3483-3486 Tidskriftsartikel (refereegranskat)
2.	Bäckbro, Kristina, et al. (författare) Cyclic urea and sulfamide-based inhibitors of HIV-1 protease: Changes in binding mode upon modifications in the P1/P1 side chain 1998 Ingår i: Antiviral Research. - 0166-3542 .- 1872-9096. ; 37, s. A56-A56 Tidskriftsartikel (refereegranskat)
3.	Hultén, Johan, et al. (författare) Cyclic 7-membered sulfamide HIV-1 protease inhibitors 1998 Ingår i: Antiviral Research. - 0166-3542 .- 1872-9096. ; 37, s. A57-A57 Tidskriftsartikel (refereegranskat)
4.	Hultén, Johan, et al. (författare) Cyclic HIV-1 protease inhibitors derived from mannitol : synthesis, inhibitory potencies, and computational predictions of binding affinities 1997 Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 40:6, s. 885-897 Tidskriftsartikel (refereegranskat)abstract Ten C-2-symmetric cyclic urea and sulfamide derivatives have been synthesized from L-mannonic gamma-lactone and D-mannitol. The results of experimental measurement of their inhibitory potencies against HIV-1 protease were compared to calculated free energies of binding derived from molecular dynamics (MD) simulations. The compounds were selected, firstly, to enable elucidation of the role of stereochemistry for binding affinity (1a-d) and, secondly, to allow evaluation of the effects of variation in the link to the P1 and P1' phenyl groups on affinity (la and 2-5). Thirdly, compounds with hydrogen bond-accepting or -donating groups attached to the phenyl groups in the P2 and P2' side chains (6 and 7) were selected. Binding free energies were estimated by a linear response method, whose predictive power for estimating binding affinities from MD simulations was demonstrated.
5.	Hultén, Johan, et al. (författare) Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains 1999 Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 42:20, s. 4054-4061 Tidskriftsartikel (refereegranskat)
6.	Hämäläinen, Markku D., et al. (författare) Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen 2000 Ingår i: Journal of Biomolecular Screening. - : Elsevier BV. - 1087-0571 .- 1552-454X. ; 5:5, s. 353-359 Tidskriftsartikel (refereegranskat)abstract The interaction between 290 structurally diverse human immunodeficiency virus type 1 (HIV-1) protease inhibitors and the immobilized enzyme was analyzed with an optical biosensor, Although only a single concentration of inhibitor was used, information about the kinetics of the interaction could be obtained by extracting binding signals at discrete time points. The statistical correlation between the biosensor binding data, inhibition of enzyme activity (K-i), and viral replication (EC50) revealed that the association and dissociation rates for the interaction could be resolved and that they were characteristic for the compounds. The most potent inhibitors, with respect to K-i and EC50 values, including the clinically used drugs, all exhibited fast association and slow dissociation rates. Selective or partially selective binders for HIV-1 protease could be distinguished from compounds that showed a general protein-binding tendency by using three reference target proteins. This biosensor-based direct binding assay revealed a capacity to efficiently provide high-resolution information on the interaction kinetics and specificity of the interaction of a set of compounds with several targets simultaneously.
7.	Markgren, Per-Olof, et al. (författare) Relationships between structure and interaction kinetics for HIV-1 protease inhibitors 2002 Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 45:25, s. 5430-5439 Tidskriftsartikel (refereegranskat)
8.	Niklasson, Gunilla, et al. (författare) Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol 1996 Ingår i: Journal of carbohydrate chemistry. - : Informa UK Limited. - 0732-8303 .- 1532-2327. ; 15:5, s. 555-569 Tidskriftsartikel (refereegranskat)
9.	Nöteberg, Daniel, et al. (författare) Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors 1997 Ingår i: Tetrahedron. - 0040-4020 .- 1464-5416. ; 53:23, s. 7975-7984 Tidskriftsartikel (refereegranskat)abstract The synthesis of the four diastereomeric 2-aminocyclopentanecarboxylic acids, their use as replacements for proline in potential HIV protease inhibitors containing a hydroxyethylamine dipeptide isostere and the evaluation of the biological activity of these is described.
10.	Schaal, Wesley, et al. (författare) Synthesis and comperative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors 2001 Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 44:2, s. 155-169 Tidskriftsartikel (refereegranskat)

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Resultat 1-10 av 65

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Typ av publikation: tidskriftsartikel (48); annan publikation (10); konferensbidrag (3); rapport (2); doktorsavhandling (1); bokkapitel (1); visa fler...; visa färre...

Typ av innehåll: refereegranskat (51); övrigt vetenskapligt/konstnärligt (14)

Författare/redaktör: Danielson, U. Helena (27); Hallberg, Anders (24); Karlén, Anders (22); Samuelsson, Bertil (17); Åkerblom, Eva (16); Classon, Björn (12); visa fler...; Lindeberg, Gunnar (11); Sandström, Anja (11); Danielson, Anders (10); Hultén, Johan (8); Nillroth, Ulrika (8); Poliakov, Anton (7); Johansson, Anja (7); Schaal, Wesley (6); Unge, Torsten (6); Danielson, Helena (5); Danielson, U. Helena ... (5); Kvarnström, Ingemar (5); Markgren, Per-Olof (5); Holm, Jerker (5); Alterman, Mathias (4); Alogheli, Hiba (4); Wretstrand, Anders (4); Hedlund, Rune (3); Vrang, Lotta (3); Winiwarter, Susanne (3); Ahlsén, Göran (3); Andersson, Hans O. (3); Linde, Torbjörn (3); Örtqvist, Pernilla (3); Rönn, Robert (3); Danielson, Bo G. (3); Larsson, Anders (2); Danielson, Mats, 195 ... (2); Fromell, Karin (2); Wretenberg, Per, 196 ... (2); Artursson, Per (2); Rydberg, Johan (2); Baltzer, Lars (2); Svensson, Richard (2); Norberg, Thomas (2); Kvarnstrom, Ingemar (2); Hämäläinen, Markku (2); Danielson, Mats (2); Bergman, Sara (2); Nonglaton, Guillaume (2); Sandhagen, Bo (2); Dahl, Göran (2); Hägg, Anders (2); Buttner, Frank (2); visa färre...

Lärosäte: Uppsala universitet (42); Lunds universitet (14); Göteborgs universitet (4); Kungliga Tekniska Högskolan (2); Stockholms universitet (2); Örebro universitet (2); visa fler...; Mittuniversitetet (2); Umeå universitet (1); Nordiska Afrikainstitutet (1); Linköpings universitet (1); Karolinska Institutet (1); visa färre...

Språk: Engelska (63); Svenska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (29); Naturvetenskap (20); Samhällsvetenskap (13); Teknik (2)

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