| 1. |
- Hössjer, Therese, et al.
(författare)
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Complication rate after gastrostomy placement in children can be reduced by simple surgical steps
- 2023
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Ingår i: Acta Pædiatrica. - : John Wiley & Sons. - 1651-2227 .- 0803-5253. ; 112:7, s. 1597-1604
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To evaluate if the incidence of postoperative complications after gastrostomy placement is correlated to perioperative parameters or patient characteristics.METHODS: In this prospective observational study, children <18 years of age planned to receive a gastrostomy at partaking clinics between 2014 and 2019 were invited. Pre-, peri- and postoperative variables were collected and followed up 3 months postoperatively.RESULTS: Five hundred and eighty-two patients were included (median age: 26 months, median weight: 10.8 kg), mainly laparoscopic (52.0%) and push-PEG (30.2%) technique used. The incidence of complications was lower in the group of patients receiving a gastrostomy tube that was 2 mm longer than the gastrostomy canal (p < 0.001-0.025), and a thickness of 12 Fr (p < 0.001-0.009). These findings were confirmed by multivariate analysis also including operative technique, age and weight. Patients with oncological disease had significantly higher incidence of pain and infection but the lowest incidence of granulomas (p < 0.001-0.01).CONCLUSION: This study indicates that a 12 Fr gastrostomy tube that is 2 mm longer than the gastrostomy canal is correlated with the lowest incidence of postoperative complications the first 3 months after surgery. Oncological patients had the lowest incidence of granulomas which probably is related to chemotherapy.
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| 2. |
- Poch, Christine M, et al.
(författare)
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Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors
- 2022
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Ingår i: Nature Cell Biology. - Stockholm : Karolinska Institutet, Dept of Cell and Molecular Biology. - 1465-7392 .- 1476-4679.
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Tidskriftsartikel (refereegranskat)abstract
- Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft crosstalk remains elusive. Here, by combining lineage tracing and single-cell transcriptomics in injured non-human primate heart biomimics, we uncover the coordinated action modes of human progenitor-mediated muscle repair. Chemoattraction via CXCL12/CXCR4 directs cellular migration to injury sites. Activated fibroblast repulsion targets fibrosis by SLIT2/ROBO1 guidance in organizing cytoskeletal dynamics. Ultimately, differentiation and electromechanical integration lead to functional restoration of damaged heart muscle. In vivo transplantation into acutely and chronically injured porcine hearts illustrated CXCR4-dependent homing, de novo formation of heart muscle, scar-volume reduction and prevention of heart failure progression. Concurrent endothelial differentiation contributed to graft neovascularization. Our study demonstrates that inherent developmental programmes within cardiac progenitors are sequentially activated in disease, enabling the cells to sense and counteract acute and chronic injury.
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| 3. |
- Trotta, Joe, et al.
(författare)
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Image-based Online Communication: Observations on the Status of Images as Linguistic Constituentss in Computer-mediated Communication
- 2011
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Ingår i: McLuhan Galaxy Conference: Understanding Media, Today. - 9788493880217
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Konferensbidrag (refereegranskat)abstract
- In this paper we look at the use of digital photographs and images as a McLuhanesque extension of written language in computer-mediated communication (CMC). Borrowing the analytical tools of Systemic Functional Linguistics (SFL), sociolinguistics, semiotics and conventional grammatical analysis, we explore user-generated multimodal utterances in the everyday conversational exchanges of selected internet messageboards. Representative examples are presented and discussed in terms of SFL metafunctions, sociolinguistic pressures, grammatical categories and occasionally semiotic signification. We highlight the use of images in CMC as markers of linguistic identity which are understood through the conventionalized meaning-making practices of some online communities.
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