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| 2. |
- Wang, Anqi, et al.
(författare)
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
- 2023
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:12, s. 2065-2074
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Tidskriftsartikel (refereegranskat)abstract
- The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
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| 3. |
- Bjelosevic, Haris, et al.
(författare)
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Platinum(II) and gold(I) complexes based on 1,1 '-bis(diphenylphosphino)metallocene derivatives: Synthesis, characterization and biological activity of the gold complexes
- 2012
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Ingår i: Journal of Organometallic Chemistry. - : Elsevier BV. - 0022-328X. ; 720, s. 52-59
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis of series of 1,2,1' substituted bis(diphenylphosphino)- ruthenocenyl (1-4) and ferrocenyl cis-platinum(II) (5-7) and gold(I) (8-12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1 ,2-bis(diphenylphosphino)ruthenocene-kappa P-2,P'}bis[chlorogold(I)] (8) (IC50 = 1.40 mu M), {1-[1-(acetoxyethyl)-1',2-bis(diphenylphosphino)ferrocene-kappa P-2,P']bis[chlorogold(1)] (9) (IC50 = 0.51 mu M), {1-[1-(3-carboxypropanamido)ethyl]-1',2-bis(diphenylphosphino)-ruthenocene kappa P-2,P'} bis[chlorogold(I)] (12) (IC50 = 1.784 mu M), have the best activities against cancer, HIV and malaria respectively. (C) 2012 Elsevier B.V. All rights reserved.
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| 4. |
- Bourikas, Leonidas, et al.
(författare)
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Addressing the challenge of interpreting microclimatic weather data collected from urban sites
- 2013
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Ingår i: Journal of Energy and Power Engineering. - : Scientific Research Publishing, Inc.. - 1934-8975 .- 1934-8983. ; 1:5, s. 7-15
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents some installation and data analysis issues from an ongoing urban air temperature and humidity measurement campaign in Hangzhou and Ningbo, China. The location of the measurement sites, the positioning of the sensors and the harsh conditions in an urban environment can result in missing values and observations that are unre-presentative of the local urban microclimate. Missing data and erroneous values in micro-scale weather time series can produce bias in the data analysis, false correlations and wrong conclusions when deriving the specific local weather patterns. A methodology is presented for the identification of values that could be false and for determining whether these are “noise”. Seven statistical methods were evaluated in their performance for replacing missing and erroneous values in urban weather time series. The two methods that proposed replacement with the mean values from sensors in locations with a Sky View Factor similar to that of the target sensor and the sensors closest to the target’s location per-formed well for all Day-Night and Cold-Warm days scenarios. However, during night time in warm weather the re-placement with the mean values for air temperature of the nearest locations outperformed all other methods. The results give some initial evidence of the distinctive urban microclimate development in time and space under different regional weather forcings.
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| 6. |
- Czaun, Miklos, et al.
(författare)
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An investigation of Cu(II) and Ni(II)-catalysed hydrolysis of (di)imines
- 2010
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Ingår i: Inorganica Chimica Acta. - : Elsevier BV. - 0020-1693. ; 363:12, s. 3102-3112
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Tidskriftsartikel (refereegranskat)abstract
- The reactions of six diimine ligands with Cu(II) and Ni(II) halide salts have been investigated. The diimine ligands were Ph2C=N(CH2)(n)NC=Ph-2 (n = 2 (Bz(2)en, 1a), 3 (Bz(2)pn, 1b), 4 (Bz2bn, 1c)), N, N'-bis-(2-tert-butylthio- 1-ylmethylenebenzene)-2,2'diamino-biphenyl (2), N,N'-bis-(2-chloro-1-ylmethylenebenzene)-1,3diaminobenzene (3) and N,N'-bis-(2-chloro-1-ylmethylenebenzene)-1,2-ethanediamine (4). Reactions of 1a-c, 2-4 with CuCl2 center dot 2H(2)O in dry ethanol at ambient temperature led to complete or partial hydrolysis of the diimine ligands to ultimately form copper diamine complexes. The non-hydrolyzed complexes of 1b and 1c, [Cu(L)Cl-2] (L = 1b, 1c), could be isolated when the reactions were carried out at low temperatures, and the half-hydrolyzed complex [Cu(Bzpn)Cl-2] could also be identified via X-ray crystallography. Similarly, reactions of 1a or 1b with NiCl2 center dot 6H(2)O or [NiBr2(dme)] led to rapid hydrolysis of the imines and Ni complexes containing half-hydrolyzed 1a (Bzen; [trans-[Ni(Bzen)(2)Br-2]) and 1b (Bzpn; [Ni(Bzpn) Br-2] could be isolated and identified via single crystal X-ray analysis. Kinetic studies were made of the hydrolyses of 1a, 1b in THF and 2 in acetone, in the presence of Cu(II), and of 1a in acetonitrile, in the presence of Ni(II). Activation parameters were determined for the latter reaction and for the copper-catalyzed hydrolysis of 2; the relatively large negative activation entropies clearly indicate rate-determining steps of an associative nature.
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| 7. |
- Ojwach, S. O., et al.
(författare)
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Substituted (pyridinyl)benzoazole palladium complexes: Synthesis and application as Heck coupling catalysts
- 2007
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Ingår i: Polyhedron. - : Elsevier BV. - 0277-5387. ; 26:18, s. 5544-5552
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis of 2-(4-tert-butylpyridin-2-yl)-benzooxazole (L3), 2-(4-tert-butyl-pyridin-2-yl)-benzothiazole (L4) and 6-tert-Butyl-2(4-tert-butyl-pyridin-2-yl)-benzothiazole (L5) by intramolecular cyclization under basic conditions is described. Reactions of 2-pyridin-2-yl-1H-benzoimidazole (L2), 2-pyridin-2-yl-benzothiazole (L2) and L3-L5 with either [Pd(NCMe)(2)Cl-2)] or [Pd(COD)MeCl] afforded the corresponding mononuclear palladium complexes [Pd(L1)MeCl] (1), [Pd(L2)MeCl] (2), [Pd(L3)Cl-2] (3), [Pd(L3)MeCl] (4), [Pd(L4)Cl-2] (5), [Pd(L4)MeCl] (6) and [Pd(L4)MeCl] (7) as confirmed by mass spectrometry and elemental analyses. The palladium complexes are efficient Heck coupling catalysts for the reaction of iodobenzene with butylacrylate under mild conditions. Benzothiazole and benzooxazole containing complexes show faster induction periods compared to the benzoimidazole analogues. (C) 2007 Elsevier Ltd. All rights reserved.
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| 8. |
- Tshuma, Piwai, et al.
(författare)
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Cyclometalation of lanthanum(iii) based MOF for catalytic hydrogenation of carbon dioxide to formate
- 2020
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 10:6, s. 3593-3605
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Tidskriftsartikel (refereegranskat)abstract
- The hydrogenation of carbon dioxide (CO2) to formic acid is of great importance due to its useful properties in the chemical industry. In this work, we have prepared a novel metal-organic framework (MOF), JMS-1, using bipyridyl dicarboxylate linkers, with molecular formula [La2(bpdc)3(DMF)3]n. Network analysis of JMS-1 revealed a new 7-connected topology (zaz). The MOF backbone of the activated phase (JMS-1a) was functionalized by cyclometalation using [RuCl2(p-cymene)]2 to produce Ru(ii)@JMS-1a. Both JMS-1a and Ru(ii)@JMS-1a were able to convert CO2 in the presence of hydrogen to formate. Ru(ii)@JMS-1a displayed outstanding conversion evidenced by a yield of 98% of formate under optimized conditions of total pressure 50 bar (CO2/H2 = 1 : 4, temperature 110 °C, time 24 h, 5 mmol KOH, 8 mL ethanol). This work is significant in providing new strategies of incorporating active catalytic centres in MOFs for efficient and selective conversion of CO2 to formate.
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