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Numrering	Referens	Omslagsbild	Hitta
1.	Lane, JM, et al. (författare) Biological and clinical insights from genetics of insomnia symptoms 2019 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:3, s. 387- Tidskriftsartikel (refereegranskat)
2.	Nassan, M, et al. (författare) Genetic evidence for a potential causal relationship between insomnia symptoms and suicidal behavior: a Mendelian randomization study 2022 Ingår i: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. - : Springer Science and Business Media LLC. - 1740-634X. ; 47:9, s. 1672-1679 Tidskriftsartikel (refereegranskat)abstract Insomnia and restless leg syndrome (RLS) are associated with increased risk for suicidal behavior (SB), which is often comorbid with mood or thought disorders; however, it is unclear whether these relationships are causal. We performed a two-sample Mendelian randomization study using summary-level genetic associations with insomnia symptoms and RLS against the outcomes of risk of major depressive disorder (MDD), bipolar disorder (BP), schizophrenia (SCZ), and SB. The inverse-variance weighted method was used in the main analysis. We performed replication and sensitivity analyses to examine the robustness of the results. We identified outcome cohorts for MDD (n = 170,756 cases/329,443 controls), BP (n = 20,352/31,358), SCZ (n = 69,369/236,642), SB-Cohort-2019 (n = 6569/14,996 all with MDD, BP or SCZ; and SB within individual disease categories), and SB-Cohort-2020 (n = 29,782/519,961). Genetically proxied liability to insomnia symptoms significantly associated with increased risk of MDD (odds ratio (OR) = 1.23, 95% confidence interval (CI) = 1.2–1.26, P = 1.37 × 10–61), BP (OR = 1.15, 95% CI = 1.07–1.23, P = 5.11 × 10–5), SB-Cohort-2019 (OR = 1.17, 95% CI = 1.07–1.27, P = 2.30 × 10–4), SB-Cohort-2019 in depressed patients (OR = 1.34, 95% CI = 1.16–1.54, P = 5.97 × 10–5), and SB-Cohort-2020 (OR = 1.24, 95% CI = 1.18–1.3, P = 1.47 × 10–18). Genetically proxied liability to RLS did not significantly influence the risk of any of the outcomes (all corrected P > 0.05). Results were replicated for insomnia with MDD and SB in Mass General Brigham Biobank and were consistent in multiple lines of sensitivity analyses. In conclusion, human genetic evidence supports for the first time a potentially independent and causal effect of insomnia on SB and encourages further clinical investigation of treatment of insomnia for prevention or treatment of SB.
3.	Polimanti, R, et al. (författare) Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium 2019 Ingår i: Psychological medicine. - 1469-8978. ; 49:7, s. 1218-1226 Tidskriftsartikel (refereegranskat)
4.	Schiel, JE, et al. (författare) Associations between sleep health and amygdala reactivity in the UK biobank cohort (n=25,758) 2022 Ingår i: JOURNAL OF SLEEP RESEARCH. - 0962-1105. ; 31 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
5.	Schiel, JE, et al. (författare) Associations Between Sleep Health and Amygdala Reactivity to Negative Facial Expressions in the UK Biobank Cohort 2022 Ingår i: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 92:9, s. 693-700 Tidskriftsartikel (refereegranskat)
6.	Schiel, JE, et al. (författare) Associations between sleep health and grey matter volume in the UK Biobank cohort (n = 33 356) 2023 Ingår i: Brain communications. - 2632-1297. ; 5:4, s. fcad200- Tidskriftsartikel (refereegranskat)
7.	Wray, NR, et al. (författare) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression 2018 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 50:5, s. 668- Tidskriftsartikel (refereegranskat)
8.	Wu, D, et al. (författare) Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019 2023 Ingår i: EClinicalMedicine. - 2589-5370. ; 64, s. 102193- Tidskriftsartikel (refereegranskat)

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Resultat 1-8 av 8

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Typ av publikation: tidskriftsartikel (7); konferensbidrag (1)

Typ av innehåll: refereegranskat (7); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Li, Y. (2); Wang, H. (2); Wu, Y. (2); Horn, C. (2); Mbarek, H (2); Steinberg, S (2); visa fler...; Hottenga, JJ (2); Willemsen, G (2); Davies, G (2); Jansen, R (2); Agrawal, A (2); Baune, BT (2); Wang, YP (2); Abdellaoui, A (2); Sullivan, PF (2); Boomsma, DI (2); Nivard, MG (2); Pedersen, NL (2); Tiemeier, H (2); Penninx, BWJH (2); Yang, J. (2); Breen, G (2); Pedersen, MG (2); Mortensen, PB (2); Craddock, N (2); Werge, T (2); Webb, BT (2); Berger, K. (2); Giusti-Rodriguez, P (2); Hu, M. (2); Hoffmann, P (2); Schaefer, C (2); Mattheisen, M (2); Milaneschi, Y (2); Shen, L (2); Teumer, A (2); Cichon, S (2); Grabe, HJ (2); Homuth, G (2); McIntosh, AM (2); Montgomery, GW (2); Muller-Myhsok, B (2); Nauck, M (2); Nothen, MM (2); Rietschel, M (2); Smoller, JW (2); Uitterlinden, AG (2); Volzke, H (2); Deary, IJ (2); Martin, NG (2); visa färre...

Lärosäte: Karolinska Institutet (8)

Språk: Engelska (8)

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