| 1. |
- Angelo, Kristina M., et al.
(författare)
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Zika among international travellers presenting to GeoSentinel sites, 2012-2019 : implications for clinical practice
- 2020
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Ingår i: Journal of Travel Medicine. - : Oxford University Press. - 1195-1982 .- 1708-8305. ; 27:4
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: International travellers contribute to the rapid spread of Zika virus (ZIKV) and its sentinel identification globally. We describe ZIKV infections among international travellers seen at GeoSentinel sites with a focus on ZIKV acquired in the Americas and the Caribbean, describe countries of exposure and traveller characteristics, and assess ZIKV diagnostic testing by site. Methods: Records with an international travel-related diagnosis of confirmed or probable ZIKV from January 2012 through December 2019 reported to GeoSentinel with a recorded illness onset date were included to show reported cases over time. Records from March 2016 through December 2019 with an exposure region of the Americas or the Caribbean were included in the descriptive analysis. A survey was conducted to assess the availability, accessibility and utilization of ZIKV diagnostic tests at GeoSentinel sites. Results: GeoSentinel sites reported 525 ZIKV cases from 2012 through 2019. Between 2012 and 2014, eight cases were reported, and all were acquired in Asia or Oceania. After 2014, most cases were acquired in the Americas or the Caribbean, a large decline in ZIKV cases occurred in 2018-19. Between March 2016 and December 2019, 423 patients acquired ZIKV in the Americas or the Caribbean, peak reporting to these regions occurred in 2016 [330 cases (78%)]. The median age was 36 years (range: 3-92); 63% were female. The most frequent region of exposure was the Caribbean (60%). Thirteen travellers were pregnant during or after travel; one had a sexually acquired ZIKV infection. There was one case of fetal anomaly and two travellers with Guillain-Barre syndrome. GeoSentinel sites reported various challenges to diagnose ZIKV effectively. Conclusion: ZIKV should remain a consideration for travellers returning from areas with risk of ZIKV transmission. Travellers should discuss their travel plans with their healthcare providers to ensure ZIKV prevention measures are taken.
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| 2. |
- Campbell, Brittany B., et al.
(författare)
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Comprehensive Analysis of Hypermutation in Human Cancer
- 2017
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Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 171:5
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Tidskriftsartikel (refereegranskat)abstract
- © 2017 Elsevier Inc. We present an extensive assessment of mutation burden through sequencing analysis of > 81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused by chemotherapy, carcinogens, or germline alterations. Hypermutation was detected in tumor types not previously associated with high mutation burden. Replication repair deficiency was a major contributing factor. We uncovered new driver mutations in the replication-repair-associated DNA polymerases and a distinct impact of microsatellite instability and replication repair deficiency on the scale of mutation load. Unbiased clustering, based on mutational context, revealed clinically relevant subgroups regardless of the tumors' tissue of origin, highlighting similarities in evolutionary dynamics leading to hypermutation. Mutagens, such as UV light, were implicated in unexpected cancers, including sarcomas and lung tumors. The order of mutational signatures identified previous treatment and germline replication repair deficiency, which improved management of patients and families. These data will inform tumor classification, genetic testing, and clinical trial design. A large-scale analysis of hypermutation in human cancers provides insights into tumor evolution dynamics and identifies clinically actionable mutation signatures.
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| 3. |
- Davidson, Kristina, et al.
(författare)
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Following the thread of Ariadne to the health of women
- 1996
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Ingår i: Health Care for Women International. - : Routledge. - 0739-9332 .- 1096-4665. ; 17:3, s. 201-208
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Tidskriftsartikel (refereegranskat)abstract
- The health of women has risen to a priority position in medical research. Comparative studies of female morbidity are called for as an intermediary stage for generation of hypotheses and design of deeper studies of determinants, such as social, ecological, and individual factors. In previous studies, we have noted differences in female hospitalization between Heraklion in Greece and Linköping in Sweden. They were related to age and to urban versus rural dwelling, and fit projections for a more archaic and a more technocratic society, respectively. This paper aims at showing how the study of women's health may proceed from relevant hospitalization observations to the next level, of exploring already available indicators of self‐perceived health in elderly females.
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| 4. |
- Davidson Söderman, Kristina, 1958-
(författare)
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Hospital admissions in Greece and Sweden : a comparative study of two communities
- 2002
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis reports comparative studies of admissions to regional hospitals in two communities, one in Greece and one in Sweden, during a two-year period, 1986-1987. The comparison was made using care episode diagnoses coded in the International Classification of Diseases, ICD 9. All cases hospitalised during this period were distributed by age, sex, residence and diagnoses.The results indicate that even if there were cultural and socio-economic differences between the two areas, there were also important similarities in the hospitalisation patterns. The hospitalisations seemed to be more equally distributed between the sexes and between urban and rural areas in Sweden than in Greece, where it appeared that the rural population, and women in particular, did not get hospital care according to their needs. It was also found that study of hospital admission is associated with methodological difficulties because the use of hospital services is a complex phenomenon. The thesis includes discussions about the variety of factors that can have influenced the results.
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| 5. |
- Fioretos, Michael, et al.
(författare)
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Hospital admissions in two European landscapes - comparison between Heraklion, Greece and Linköping
- 1993
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Ingår i: International Journal of Health Sciences. - 0924-2287. ; 4, s. 33-39
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Tidskriftsartikel (refereegranskat)abstract
- The study describes a comparison of hospital admissions during a two-year period between a regional hospital in Heraklion (Greece) and a regional hospital in Linköping (Sweden). The findings are considered mainly in terms of health care delivery and utilization in relation to various types of demographic factors.The results indicate that despite the different cultural and socio-economic environments in the studied districts, there are important similarities of hospitalisation pattern in the urban areas. However, there are also notable differences. The hospitalisation pattern seems to be more equally distributed between sexes and between urban and rural areas in Linköping (Sweden) than in Heraklion (Greece), where it appeared that the rural population, and women in particular, did not get hospital care according to their needs.
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| 6. |
- Tsamandouraki, Kiki, et al.
(författare)
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Hospital admissions for different cancer diagnosis : a comparison between two European landscapes
- 1994
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 14:5B, s. 2167-2170
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Tidskriftsartikel (refereegranskat)abstract
- Cancer frequency has been studied in a Department of Crete and a Department of Sweden, using in-patient data collected in the Departmental Hospitals, for a two-year period. The results of the study suggest that similar trends exist in the prevalence of different forms of cancer between the two areas studied, as well as some significant differences. The differences observed concern mainly the frequency of cancers of the lung, prostate, bladder and large bowel among men and breast and large bowel among women. These findings could to a great extent be explained by life-style and environmental differences between the two areas and are consistent with data concerning the cancer mortality in the two countries.
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| 7. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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