| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
- Arbajian, Elsa, et al.
(författare)
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Methylation patterns and chromatin accessibility in neuroendocrine lung cancer
- 2020
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 12:8, s. 1-17
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Tidskriftsartikel (refereegranskat)abstract
- Lung cancer is the worldwide leading cause of death from cancer. Epigenetic modifications such as methylation and changes in chromatin accessibility are major gene regulatory mechanisms involved in tumorigenesis and cellular lineage commitment. We aimed to characterize these processes in the context of neuroendocrine (NE) lung cancer. Illumina 450K DNA methylation data were collected for 1407 lung cancers including 27 NE tumors. NE differentially methylated regions (NE-DMRs) were identified and correlated with gene expression data for 151 lung cancers and 31 human tissue entities from the Genotype-Tissue Expression (GTEx) consortium. Assay for transposase-accessible chromatin sequencing (ATAC-seq) and RNA sequencing (RNA-seq) were performed on eight lung cancer cell lines, including three NE cell lines, to identify neuroendocrine specific gene regulatory elements. We identified DMRs with methylation patterns associated with differential gene expression and an NE tumor phenotype. DMR-associated genes could further be split into six functional modules, including one highly specific gene module for NE lung cancer showing high expression in both normal and malignant brain tissue. The regulatory potential of NE-DMRs was further validated in vitro using paired ATAC-and RNA-seq and revealed both proximal and distal regulatory elements of canonical NE-marker genes such as CHGA, NCAM1, INSM1, as well as a number of novel candidate markers of NE lung cancer. Using multilevel genomic analyses of both tumor bulk tissue and lung cancer cell lines, we identified a large catalogue of gene regulatory elements related to the NE phenotype of lung cancer.
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| 3. |
- Brolin, Karin, 1974, et al.
(författare)
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Towards omni-directional active human body models
- 2016
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Ingår i: 6th International Symposium on Human Modeling and Simulation in Automotive Engineering, Heidelberg, GERMANY, October 20-21.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Brynskog, Erik, 1989, et al.
(författare)
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Population Variance in Pelvic Response to Lateral Impacts - A Global Sensitivity Analysis
- 2022
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Ingår i: Conference proceedings International Research Council on the Biomechanics of Injury, IRCOBI. - 2235-3151. ; 2022-September, s. 173-196
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Konferensbidrag (refereegranskat)abstract
- Pelvic fracture remains the third most common moderate to severe injury in motor vehicle crashes, and the dominating lower extremity injury in lateral impacts. An essential tool for analysis of injury, and real-world occupant protection, are finite element human body models. However, today's state-of-the-art pelvis models do not adequately consider the variability in shape and size naturally occurring in human populations. In this study, we developed a new detailed pelvis finite element model, morphable to enable representation of the population shape variance. The model was validated using force-displacement data from post-mortem human subjects, in lateral loading of the denuded pelvis, followed by a global sensitivity analysis. The results suggests that in lateral impacts to the pelvis, pelvic shape contributes to the model response variance by the same magnitude as pelvic bone material stiffness, and that each of these contributions are approximately twice that of the cortical bone thickness. Hence, to model pelvic response for a general population accurately, future studies must consider both pelvic shape and the material properties in the analysis. Increased knowledge about population variability, and inclusion in safety evaluations, can result in more robust systems that reduce the risk of pelvic injuries in real-world accidents.
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| 5. |
- Brynskog, Erik, 1989, et al.
(författare)
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Predicting pelvis geometry using a morphometric model with overall anthropometric variables
- 2021
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Ingår i: Journal of Biomechanics. - : Elsevier BV. - 1873-2380 .- 0021-9290. ; 126
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Tidskriftsartikel (refereegranskat)abstract
- Pelvic fractures have been identified as the second most common AIS2+ injury in motor vehicle crashes, with the highest early mortality rate compared to other orthopaedic injuries. Further, the risk is associated with occupant sex, age, stature and body mass index (BMI). In this study, clinical pelvic CT scans from 132 adults (75 females, 57 males) were extracted from a patient database. The population shape variance in pelvis bone geometry was studied by Sparse Principal Component Analysis (SPCA) and a morphometric model was developed by multi- variate linear regression using overall anthropometric variables (sex, age, stature, BMI). In the analysis, SPCA identified 15 principal components (PCs) describing 83.6% of the shape variations. Eight of these were signifi- cantly captured (α < 0.05) by the morphometric model, which predicted 29% of the total variance in pelvis geometry. The overall anthropometric variables were significantly related to geometrical features primarily in the inferior-anterior regions while being unable to significantly capture local sacrum features, shape and position of ASIS and lateral tilt of the iliac wings. In conclusion, a new detailed morphometric model of the pelvis bone demonstrated that overall anthropometric variables account for only 29% of the variance in pelvis geometry. Furthermore, variations in the superior-anterior region of the pelvis, with which the lap belt is intended to interact, were not captured. Depending on the scenario, shape variations not captured by overall anthropometry could have important implications for injury prediction in traffic safety analysis.
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| 6. |
- Etminani, Farzaneh, 1984-, et al.
(författare)
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Randomised, siteless study to compare systematic atrial fibrillation screening using enrichment by a risk prediction model with standard care in a Swedish population aged ≥ 65 years : CONSIDERING-AF study design
- 2024
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Ingår i: BMJ Open. - London : BMJ Publishing Group Ltd. - 2044-6055. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Atrial fibrillation (AF) is the most common arrhythmia and confers an increased risk of mortality, stroke, heart failure and cognitive decline. There is growing interest in AF screening; however, the most suitable population and device for AF detection remains to be elucidated. Here, we present the design of the CONSIDERING-AF (deteCtiON and Stroke preventIon by moDEl scRreenING for Atrial Fibrillation) study. METHODS AND ANALYSIS: CONSIDERING-AF is a randomised, controlled, siteless, non-blinded diagnostic superiority trial with four parallel groups and a primary endpoint of identifying AF during a 6-month study period set in Region Halland, Sweden. In each group, 740 individuals aged≥65 years will be included. The primary objective is to compare the intervention of AF screening enrichment using a risk prediction model (RPM), followed by 14 days of a continuous ECG patch, with no intervention (standard care). Primary outcome is defined as the incident AF recorded in the Region Halland Information Database after 6 months as compared with standard care. Secondary endpoints include the difference in incident AF between groups enriched or not by the RPM, with and without an invitation to 14 days of continuous ECG recording, and the proportions of oral anticoagulation treatment in the four groups. ETHICS AND DISSEMINATION: This study has ethical approval from the Swedish Ethical Review Authority. Results will be published in peer-reviewed international journals. TRIAL REGISTRATION NUMBER: NCT05838781. © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
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| 7. |
- Iraeus, Johan, 1973, et al.
(författare)
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A new open-source finite element lumbar spine model, its tuning and validation, and development of a tissue-based injury risk function for compression fractures
- 2023
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Ingår i: Conference proceedings International Research Council on the Biomechanics of Injury, IRCOBI. - 2235-3151. ; , s. 1048-1072
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Konferensbidrag (refereegranskat)abstract
- Lumbar spine fractures have been identified as a problem in motor vehicle crashes, and it is expected that this problem might increase with the introduction of reclined postures in autonomous vehicles. Human body models provide a means to address this issue and develop countermeasures. In this study a new open-source finite element lumbar spine model and an associated tissue-based injury risk function were developed and validated. The injury risk function was based on trabecular bone compressive strain in the superior-inferior direction. The kinematic and kinetic validation showed that the model compared reasonably to experimental data, with axial compression and flexion predictions being closest to experimental results. The new risk function was found to have a good quality index. Even though the model evaluations indicated that the fracture risk was somewhat overpredicted, it was judged that the current model, together with the associated injury risk function, can be used to estimate the risk for compressive fractures in the lumbar spine, with the knowledge that these estimates are most likely somewhat conservative.
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| 8. |
- Jones, Geraint H., et al.
(författare)
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The Comet Interceptor Mission
- 2024
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Ingår i: Space Science Reviews. - : Springer Nature. - 0038-6308 .- 1572-9672. ; 220:1
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Tidskriftsartikel (refereegranskat)abstract
- Here we describe the novel, multi-point Comet Interceptor mission. It is dedicated to the exploration of a little-processed long-period comet, possibly entering the inner Solar System for the first time, or to encounter an interstellar object originating at another star. The objectives of the mission are to address the following questions: What are the surface composition, shape, morphology, and structure of the target object? What is the composition of the gas and dust in the coma, its connection to the nucleus, and the nature of its interaction with the solar wind? The mission was proposed to the European Space Agency in 2018, and formally adopted by the agency in June 2022, for launch in 2029 together with the Ariel mission. Comet Interceptor will take advantage of the opportunity presented by ESA’s F-Class call for fast, flexible, low-cost missions to which it was proposed. The call required a launch to a halo orbit around the Sun-Earth L2 point. The mission can take advantage of this placement to wait for the discovery of a suitable comet reachable with its minimum Δ V capability of 600 ms − 1 . Comet Interceptor will be unique in encountering and studying, at a nominal closest approach distance of 1000 km, a comet that represents a near-pristine sample of material from the formation of the Solar System. It will also add a capability that no previous cometary mission has had, which is to deploy two sub-probes – B1, provided by the Japanese space agency, JAXA, and B2 – that will follow different trajectories through the coma. While the main probe passes at a nominal 1000 km distance, probes B1 and B2 will follow different chords through the coma at distances of 850 km and 400 km, respectively. The result will be unique, simultaneous, spatially resolved information of the 3-dimensional properties of the target comet and its interaction with the space environment. We present the mission’s science background leading to these objectives, as well as an overview of the scientific instruments, mission design, and schedule.
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| 9. |
- Larsson, Emma, 1991, et al.
(författare)
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Active Human Body Model Predictions Compared to Volunteer Response in Experiments with Braking, Lane Change, and Combined Manoeuvres
- 2019
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Ingår i: Conference proceedings International Research Council on the Biomechanics of Injury, IRCOBI. - 2235-3151. ; :S1-9, s. 349-369
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Konferensbidrag (refereegranskat)abstract
- Active human body models are an important tool to study occupant interaction with safety systems in evasive manoeuvres such as braking and/or steering. In this study a finite element human body model with and without closed-loop active muscle control in the neck and lower trunk was compared to volunteer occupants in six different load cases with lane change, braking, and combined manoeuvres using standard and prepretensioned seat belts. Seven different muscle controllers, using two different muscle activation strategies based either on head and torso displacements or muscle length, and one with the controller turned off have been compared to volunteer kinematics. Cross-correlation analysis with CORA was used to evaluate the model biofidelity. The results show an improvement in CORA scores when using active muscles, compared to the model with muscle activity turned off, for one load case and similar CORA scores between the models for five load cases. CORA scores ranged from 0.78 to 0.88 for the active models and 0.70 to 0.82 from the model with muscles turned off. The active model gave a kinematic response with good biofidelity in lane change with braking, pure braking, and lane change with pre-pretensioned seat belt, but the biofidelity of the model was rated as fair in lane change with standard seat belt.
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| 10. |
- Larsson, Emma, 1991, et al.
(författare)
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Investigating sources for variability in volunteer kinematics in a braking maneuver, a sensitivity analysis with an active human body model
- 2023
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Ingår i: Frontiers in Bioengineering and Biotechnology. - 2296-4185. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Occupant kinematics during evasive maneuvers, such as crash avoidance braking or steering, varies within the population. Studies have tried to correlate the response to occupant characteristics such as sex, stature, age, and BMI, but these characteristics explain no or very little of the variation. Therefore, hypothesis have been made that the difference in occupant response stems from voluntary behavior. The aim of this study was to investigate the effect from other sources of variability: in neural delay, in passive stiffness of fat, muscle tissues and skin, in muscle size and in spinal alignment, as a first step towards explaining the variability seen among occupants in evasive maneuvers. A sensitivity analysis with simulations of the SAFER Human Body Model in braking was performed, and the displacements from the simulations were compared to those of volunteers. The results suggest that the head and torso kinematics were most sensitive to spinal alignment, followed by muscle size. For head and torso vertical displacements, the range in model kinematics was comparable to the range in volunteer kinematics. However, for forward displacements, the included parameters only explain some of the variability seen in the volunteer experiment. To conclude, the results indicate that the variation in volunteer vertical kinematics could be partly attributed to the variability in human characteristics analyzed in this study, while these cannot alone explain the variability in forward kinematics. The results can be used in future tuning of HBMs, and in future volunteer studies, when further investigating the potential causes of the large variability seen in occupant kinematics in evasive maneuvers.
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