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Numrering	Referens	Omslagsbild	Hitta
1.	Glasbey, JC, et al. (författare) 2021 swepub:Mat__t
2.	Adamina, M, et al. (författare) The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study 2022 Ingår i: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. - : Wiley. - 1463-1318. ; 24:6, s. 708-726 Tidskriftsartikel (refereegranskat)
3.	Mathivanan, Suresh, et al. (författare) Human Proteinpedia enables sharing of human protein data. 2008 Ingår i: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 26:2, s. 164-167 Tidskriftsartikel (refereegranskat)
4.	Zhang, Yiwen, et al. (författare) A prospective study of intraprostatic inflammation, focal atrophy, and progression to lethal prostate cancer 2019 Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 28:12, s. 2047-2054 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Inflammation and focal atrophy are common features adjacent to prostate tumors. Limited evidence exists on whether these features have prognostic significance.METHODS: In the Health Professionals Follow-Up Study and Physicians' Health Study, we studied 1,035 men diagnosed with prostate cancer. A genitourinary pathologist centrally reviewed tumor and normal areas of hematoxylin and eosin slides from prostate cancer specimens for the presence of acute and chronic inflammation, and four subtypes of focal atrophy. Cox proportional hazards models adjusted for potential confounders were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of these features with lethal prostate cancer, defined as development of metastatic disease or death during follow-up.RESULTS: During a median of 12 years of follow-up, 153 men developed lethal prostate cancer. Eighty-four percent of men had histologic evidence of chronic inflammation and 30% had acute inflammation. Both chronic and acute inflammation were inversely associated with lethal prostate cancer in age- and lifestyle-adjusted models. Chronic inflammation remained inversely associated with lethal prostate cancer after additionally adjusting for prognostic clinical features (HR=0.45, 95% CI 0.30 to 0.69 for mild, HR=0.51, 95% CI 0.33 to 0.80 for moderate to severe). None of the atrophic lesions were associated with lethal prostate cancer.CONCLUSIONS: Our data suggest that the presence of inflammation, particularly chronic inflammation, in prostate cancer tissue is associated with better prognosis among prostate cancer patients.IMPACT: This is the largest prospective cohort study to examine the association between inflammation, focal atrophy, and lethal prostate cancer.

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Resultat 1-4 av 4

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Typ av publikation: tidskriftsartikel (3)

Typ av innehåll: refereegranskat (3)

Författare/redaktör: Chen, S. (2); Lopes, L. (2); Losada, M. (2); Moss, J. (2); Nordberg, M. (2); Qureshi, A. (2); visa fler...; Romano, M. (2); Zhang, H. (2); Davies, E. (2); Gupta, A. (2); Martin, J. (2); Aytac, E (2); Cosimelli, M (2); Davies, RJ (2); Golda, T (2); Hompes, R (2); Kanemitsu, Y (2); Lakkis, Z (2); Poggioli, G (2); Rottoli, M (2); Shaikh, (2); Tsarkov, P (2); Wilson, M (2); Baker, A. (2); Persiani, R. (2); Silva, M. (2); Kumar, A. (2); Moore, R. (2); Osman, N. (2); Russ, J. (2); Williams, G. (2); Giraudo, G. (2); Sharma, N. (2); Singh, R. (2); Meneghini, S. (2); Nowak, K. (2); Costa, M. (2); Thompson, D. (2); O'Brien, S. (2); Barker, D. (2); Mukherjee, S. (2); Patel, P. (2); Khan, A. (2); Hunt, L (2); Abate, E. (2); Lee, M (2); Li, Z (2); Agrawal, A (2); Ali, M (2); Ali, S (2); visa färre...

Lärosäte: Karolinska Institutet (2); Kungliga Tekniska Högskolan (1); Örebro universitet (1); Lunds universitet (1)

Språk: Engelska (4)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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