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| 2. |
- Asselbergs, Folkert W., et al.
(författare)
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Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
- 2012
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 91:5, s. 823-838
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-analysis of 32 studies in 66,240 individuals of European ancestry was based on the custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) covering similar to 2,000 candidate genes. SNP-lipid associations were replicated either in a cohort comprising an additional 24,736 samples or within the Global Lipid Genetic Consortium. We identified four, six, ten, and four unreported SNPs in established lipid genes for HDL-C, LDL-C, TC, and TGs, respectively. We also identified several lipid-related SNPs in previously unreported genes: DGAT2, HCAR2, GPIHBP1, PPARG, and FTO for HDL-C; SOCS3, APOH, SPTY2D1, BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4, INSR, and LPAL2 for TGs. The proportion of explained phenotypic variance in the subset of studies providing individual-level data was 9.9% for HDL-C, 9.5% for LDL-C, 10.3% for TC, and 8.0% for TGs. This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci. The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.
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| 3. |
- De Wilde, Pieter, et al.
(författare)
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Analyzing Citizen Engagement With European Politics on Social Media
- 2022
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Ingår i: Politics and Governance. - : Cogitatio. - 2183-2463. ; 10:1, s. 90-96
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Contributions in this thematic issue focus explicitly on citizens and their online engagement with European politics. For social media research in the European Union, citizens remain an understudied actor type in comparison with political elites or news organizations. The reason, we argue, is four key challenges facing social media research in the European Union: legal, ethical, technical, and cultural. To introduce this thematic issue, we outline these four challenges and illustrate how they relate to each contribution. Given that these challenges are unlikely to dissipate, we stress the need for open dialogue about them. A key part of that involves contextualizing research findings within the constraints in which they are produced. Despite these challenges, the contributions showcase that a theoretical and empirical focus on citizens’ social media activity can illuminate key insights into vitally important topics for contemporary Europe. These include civic participation, institutional communication, media consumption, gender inequality, and populism.
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| 4. |
- Nik, Vahid, 1979, et al.
(författare)
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Climate Change and Wind-Driven Rain – a Preliminary Study about Climate Uncertainties
- 2013
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Ingår i: Proceedings of FutureBuild 2013; University of Bath, UK.
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Konferensbidrag (refereegranskat)abstract
- Under changing climate conditions, acceptable functionality of buildings and their adaptation to climate are required. More rain and extreme conditions in future make buildings and the built environment more vulnerable. There are currently several scenarios regarding possible future climatic conditions. Results from the impact analysis of climate change can be significantly affected by the selected climate scenario. Therefore it is recommended to do not rely on few climate scenarios while performing the impact analysis. This paper suggests a simple method to analyse the importance of climate uncertainties in the impact assessment of climate change on wind-driven rain (WDR). The method is based on the calculation of Stokes number; a dimensionless number which correlates strongly with the catch ratio of the wind-driven rain. Preliminary results have been obtained by studying the distribution of Stokes number during 1961-2100 for several climate scenarios. Distributions demonstrate the probable differences in WDR calculations, induced by the climate uncertainties. Three uncertainty factors are considered in this work; global climate models, initial conditions and spatial resolutions of the climate scenarios. Based on the results all the three factors can induce changes in WDR calculations. However the magnitudes of changes are not the same among the uncertainty factors. Using the Stokes number helps to evaluate the importance of climate uncertainties before the WDR simulations.
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| 5. |
- Nik, Vahid, et al.
(författare)
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Future moisture loads for building facades in Sweden: Climate change and wind-driven rain
- 2015
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Ingår i: Building and Environment. - : Elsevier BV. - 1873-684X .- 0360-1323. ; 93, s. 362-375
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Tidskriftsartikel (refereegranskat)abstract
- This work investigates the prospective impacts of climate change on wind-driven rain (WDR) and walls through simulating the hygrothermal performance of rain screen of common vertical wall constructions for the climatic conditions of Gothenburg in Sweden. While a substantial amount of work has been done on the impact of climate change on the thermal performance of buildings, this paper studies its impact - through changes in rain, wind and other climatic parameters - on the amount of water which penetrates the outmost layer of ventilated facades. Importance of three uncertainty factors of the climate data are investigated: uncertainties from global climate models, emissions scenarios and spatial resolutions. Consistency of the results is examined by modelling walls with different materials and sizes, as well as using two mathematical approaches for WDR modelling. Sensitivity of the wall simulations to the wind data is assessed by using synthetic climate with sole wind data. According to the results, higher amounts of moisture will accumulate in walls in the future; climate Uncertainties can cause variations up to 13% in the calculated 30-year average of water content and 28% in its standard deviation. Using sole wind data can augment uncertainties with up to 10% in WDR calculations, however it is possible to neglect changes in future wind data. (C) 2015 Elsevier Ltd. All rights reserved.
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| 6. |
- Pan, Song, et al.
(författare)
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Energy waste in buildings due to occupant behaviour
- 2017
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Ingår i: Energy Procedia. - : Elsevier BV. - 1876-6102. ; 105, s. 2233-2238
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Tidskriftsartikel (refereegranskat)abstract
- Occupants’ behaviour has a significant impact on the energy performance of buildings. A good understanding of how occupants use a building provides a possibility of promoting the building's energy efficiency through changing occupant behaviour. Building simulation has been adopted as a useful method by building engineers for quantifying the effects of changing occupant behaviour on the building's energy consumption and indoor environment. However, due to the lack of real measured data with respect to how occupants use the building, such simulation work has relied on assumed behavioural patterns, which significantly reduces the reliability of the predicted results. This paper describes a longitudinal study monitoring occupants’ heating, window opening and cooling behaviour in an office building throughout summer, transitional and winter periods. These behavioural data were then used to drive dynamic building performance simulation to predict the energy saving potential of changing behaviour. Comparison with predicted results by assumed behavioural patterns reflected that improperly assumed behavioural patterns may either overestimate or underestimate the energy saving potential of changing behaviour, especially for unextreme behaviours.
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| 7. |
- Zhou, Xianzhi, et al.
(författare)
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Dynamic Drivers for Building Carbon Emissions
- 2023
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Ingår i: Building Simulation Conference Proceedings. ; 18, s. 1193-1200
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Konferensbidrag (refereegranskat)abstract
- Carbon emissions from buildings have inherently dynamic characteristics since buildings evolve over time. Most previous studies, however, implemented static building carbon regimes, ignoring the temporal variation of many factors that govern carbon emissions of buildings. This research explores the influences of four dynamic factors acting on building carbon emissions: dynamic climate change data, dynamic electricity carbon emission factors, dynamic variations in building insulation levels, and dynamic degradation of mechanical components. Results indicate that the effects of these dynamic factors are very complex, depending on energy types, maintenance approach, refurbishment rate, and socioeconomic scenarios. Much more research is required to understand the dynamic nature of building carbon emissions and make more accurate long-term predictions using simulation.
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