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| 2. |
- Hillyard, P. B., et al.
(författare)
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Carrier-density-dependent lattice stability in InSb
- 2007
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:12, s. 125501-
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Tidskriftsartikel (refereegranskat)abstract
- The ultrafast decay of the x-ray diffraction intensity following laser excitation of an InSb crystal has been utilized to observe carrier dependent changes in the potential energy surface. For the first time, an abrupt carrier dependent onset for potential energy surface softening and the appearance of accelerated atomic disordering for a very high average carrier density have been observed. Inertial dynamics dominate the early stages of crystal disordering for a wide range of carrier densities between the onset of crystal softening and the appearance of accelerated atomic disordering.
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| 3. |
- Lindenberg, A. M., et al.
(författare)
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X-ray diffuse scattering measurements of nucleation dynamics at femtosecond resolution.
- 2008
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 100:13, s. 135502-1-135502-5
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Tidskriftsartikel (refereegranskat)abstract
- Femtosecond time-resolved small and wide angle x-ray diffuse scattering techniques are applied to investigate the ultrafast nucleation processes that occur during the ablation process in semiconducting materials. Following intense optical excitation, a transient liquid state of high compressibility characterized by large-amplitude density fluctuations is observed and the buildup of these fluctuations is measured in real time. Small-angle scattering measurements reveal snapshots of the spontaneous nucleation of nanoscale voids within a metastable liquid and support theoretical predictions of the ablation process.
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| 6. |
- Romano, K. A., et al.
(författare)
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Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure
- 2023
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Ingår i: Circulation-Heart Failure. - : Ovid Technologies (Wolters Kluwer Health). - 1941-3289 .- 1941-3297. ; 16:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The gut microbiota-dependent metabolite phenylacetylgutamine (PAGln) is both associated with atherothrombotic heart disease in humans, and mechanistically linked to cardiovascular disease pathogenesis in animal models via modulation of adrenergic receptor signaling.Methods: Here we examined both clinical and mechanistic relationships between PAGln and heart failure (HF). First, we examined associations among plasma levels of PAGln and HF, left ventricular ejection fraction, and N-terminal pro-B-type natriuretic peptide in 2 independent clinical cohorts of subjects undergoing coronary angiography in tertiary referral centers (an initial discovery US Cohort, n=3256; and a validation European Cohort, n=829). Then, the impact of PAGln on cardiovascular phenotypes relevant to HF in cultured cardiomyoblasts, and in vivo were also examined.Results: Circulating PAGln levels were dose-dependently associated with HF presence and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors and renal function in both cohorts. Beyond these clinical associations, mechanistic studies showed both PAGln and its murine counterpart, phenylacetylglycine, directly fostered HF-relevant phenotypes, including decreased cardiomyocyte sarcomere contraction, and B-type natriuretic peptide gene expression in both cultured cardiomyoblasts and murine atrial tissue.Conclusions: The present study reveals the gut microbial metabolite PAGln is clinically and mechanistically linked to HF presence and severity. Modulating the gut microbiome, in general, and PAGln production, in particular, may represent a potential therapeutic target for modulating HF.Registration: URL: ; Unique identifier: NCT00590200 and URL: ; Unique identifier: DRKS00020915.
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| 7. |
- Stolte, W. C., et al.
(författare)
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Inner-shell photoionization of atomic chlorine
- 2013
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 88:5
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Tidskriftsartikel (refereegranskat)abstract
- Relative partial cross sections have been measured following photoexcitation of atomic chlorine near the Cl 2p and Cl 1s ionization thresholds. In addition, Breit-Pauli R-matrix calculations have been carried out in the region of the 2p thresholds, and the results are compared with experiment. Owing to angular-momentum considerations, it was found that the resonances associated with the higher 2p(-1) thresholds should be significantly wider than the lower ones, and this is borne out in both the experimental and the theoretical results. It is shown that a large number of resonance series contribute to the cross section, which make it difficult to untangle, and suggestions for further work to better understand the spectra are presented.
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| 8. |
- Deb, S., et al.
(författare)
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SUPERIOR SVG: no touch saphenous harvesting to improve patency following coronary bypass grafting (a multi-Centre randomized control trial, NCT01047449)
- 2019
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Ingår i: Journal of Cardiothoracic Surgery. - : Springer Science and Business Media LLC. - 1749-8090. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundSingle centre studies support No Touch (NT) saphenous vein graft (SVG) harvesting technique. The primary objective of the SUPERIOR SVG study was to determine whether NT versus conventional (CON) SVG harvesting was associated with improved SVG patency 1year after coronary artery bypass grafting surgery (CABG).MethodsAdults undergoing isolated CABG with at least 1 SVG were eligible. CT angiography was performed 1-year post CABG. Leg adverse events were assessed with a questionnaire. A systematic review was performed for published NT graft patency studies and results aggregated including the SUPERIOR study results.ResultsTwo hundred and-fifty patients were randomized across 12-centres (NT 127 versus CON 123 patients). The primary outcome (study SVG occlusion or cardiovascular (CV) death) was not significantly different in NT versus CON (NT: 7/127 (5.5%), CON 13/123 (10.6%), p=0.15). Similarly, the proportion of study SVGs with significant stenosis or total occlusion was not significantly different between groups (NT: 8/102 (7.8%), CON: 16/107 (15.0%), p=0.11). Vein harvest site infection was more common in the NT patients 1month postoperatively (23.3% vs 9.5%, p<0.01). Including this study's results, in a meta-analysis, NT was associated with a significant reduction in SVG occlusion, Odds Ratio 0.49, 95% Confidence Interval 0.29-0.82, p=0.007 in 3 randomized and 1 observational study at 1year postoperatively.ConclusionsThe NT technique was not associated with improved patency of SVGs at 1-year following CABG while early vein harvest infection was increased. The aggregated data is supportive of an important reduction of SVG occlusion at 1year with NT harvesting.Trial registrationNCT01047449.
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| 9. |
- Hemani, Ahmed, et al.
(författare)
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System level virtual prototyping of DSP SOCs using grammar based approach
- 2000
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Ingår i: Design automation for embedded systems. - 0929-5585 .- 1572-8080. ; 5:04-mar, s. 295-311
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Tidskriftsartikel (refereegranskat)abstract
- As we move from algorithm on a chip to system on a chip era, the design bottleneck is shifting from individual DSP functions to global control that composes a system from these functions. The practice in industry suffers from global control entering the design flow too late, discontinuity between functional modeling and implementation phase and mixing data flow with global control. MASIC-Maths to ASIC-is a methodology proposed in this paper that targets DSP SOCs and addresses these issues. Global control is specified in a grammar notation and integrates the output of functional modeling phase, the DSP functions, by referencing them. A virtual prototype is automatically built from such a specification that models the global control in VHDL and cosimulates with the DSP functions in C from the functional modeling phase. A highly efficient verification methodology based on separating the verification of global control from DSP functions is proposed. A smooth path to cycle true implementation is possible using either behavioral synthesis, IPs for the DSP functions or manual implementation. Experiments using realistic examples like GSM base band processing, rake receiver and some smaller examples have been carried out to quantify the benefits of MASIC.
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| 10. |
- Lee, Ho-Hsien, et al.
(författare)
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Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1
- 2014
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Ingår i: IUCrJ. - 2052-2525. ; 1:5, s. 305-317
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Tidskriftsartikel (refereegranskat)abstract
- CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB) andthe membrane-proximal region of gp41 (MPR), the transmembrane envelopeprotein ofHuman immunodeficiency virus 1(HIV-1), and has previously beenshown to induce the production of anti-HIV-1 antibodies with antiviralfunctions. To further improve the design of this candidate vaccine, X-raycrystallography experiments were performed to obtain structural informationabout this fusion protein. Several variants of CTB-MPR were designed,constructed and recombinantly expressed inEscherichia coli. The first variantcontained a flexible GPGP linker between CTB and MPR, and yielded crystalsthat diffracted to a resolution of 2.3 A ̊, but only the CTB region was detectedin the electron-density map. A second variant, in which the CTB was directlyattached to MPR, was shown to destabilize pentamer formation. A thirdconstruct containing a polyalanine linker between CTB and MPR proved tostabilize the pentameric form of the protein during purification. The purificationprocedure was shown to produce a homogeneously pure and monodispersesample for crystallization. Initial crystallization experiments led to pseudo-crystals which were ordered in only two dimensions and were disordered inthe third dimension. Nanocrystals obtained using the same precipitant showedpromising X-ray diffraction to 5 A ̊resolution in femtosecond nanocrystallo-graphy experiments at the Linac Coherent Light Source at the SLAC NationalAccelerator Laboratory. The results demonstrate the utility of femtosecondX-ray crystallography to enable structural analysis based on nano/microcrystalsof a protein for which no macroscopic crystals ordered in three dimensions havebeen observed before.
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