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- Dec, E, et al.
(författare)
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Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
- 2023
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Ingår i: GeroScience. - : Springer Science and Business Media LLC. - 2509-2723 .- 2509-2715.
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Tidskriftsartikel (refereegranskat)abstract
- Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome-wide association study of age in different age groups revealed that age effects in young individuals (age < 40) are correlated (r = 0.55) with age effects in old individuals (age > 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age.
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| 5. |
- Dec, E, et al.
(författare)
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Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
- 2023
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Ingår i: GeroScience. - : Springer Science and Business Media LLC. - 2509-2723 .- 2509-2715. ; 45:43, s. 1817-1835
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Tidskriftsartikel (refereegranskat)abstract
- Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome-wide association study of age in different age groups revealed that age effects in young individuals (age < 40) are correlated (r = 0.55) with age effects in old individuals (age > 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age.
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- Szrek, Piotr, et al.
(författare)
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A glimpse of a fish face : An exceptional fish feeding trace fossil from the Lower Devonian of the Holy Cross Mountains, Poland
- 2016
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Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology. - : Elsevier BV. - 0031-0182 .- 1872-616X. ; 454, s. 113-124
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Tidskriftsartikel (refereegranskat)abstract
- An exceptionally well-preserved assemblage of numerous invertebrate and vertebrate trace fossils is described from the Lower Devonian of the Holy Cross Mountains, southern Poland. Two trace-bearing horizons occur in the shallow-marine sequence that is exposed in a small outcrop near Ujazd village. One of the trace fossils is preserved as a bilobate, generally elliptical, epichnial pit is described as Osculichnus tarnowskae isp. nov. and interpreted as a unique example of praedichnia. Neoichnologic experiments and observations indicate that the ichnogenus Osculichnus was produced by feeding fish. The fish producing O. tarnowskae probably hunted bivalves, polychaetes and arthropods, which are represented by invertebrate trace fossils in the same horizons. The overall shape and morphological details of O. tarnowskae suggest that it was made by a lungfish broadly similar to Dipnorhynchus. The trace provides the first direct evidence for Devonian lungfish feeding behaviour, as well as the first record of three-dimensional soft-tissue morphology of the snout area of an Emsian representative of this group. The trace fossils from Ujazd provide new insight into the palaeoecology and taphonomy of the Lower Devonian of the Holy Cross Mountains.
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- Wilk, Olga, et al.
(författare)
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Comments on the Squamation of Polish Lower Devonian Porolepiforms
- 2019
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Ingår i: Journal of Vertebrate Paleontology. - : Informa UK Limited. - 0272-4634 .- 1937-2809. ; 39:6
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Tidskriftsartikel (refereegranskat)abstract
- Porolepiform scales from the Lower Devonian of the Holy Cross Mountains, Poland, described from the ‘placoderm sandstone’ of the Daleszyce area, are revised. The aim of the present article is to organize the recently collected, but not formally described, porolepiform material from the Holy Cross Mountains, as well as specimens from erratic boulders collected near Gdynia (northernmost Poland), which can be referred to Porolepis. Previously collected and new material was found to contain at least two sarcopterygian taxa: Porolepis and Heimenia. Based on morphological and histological features, the described material has been divided into two scale assemblages. The first, which is assigned to Porolepis, possesses cosmine cover on the entire exposed area; in the second, assigned to Heimenia, the cosmine cover is reduced or absent. These features prove to be stable regardless of the position of the scale on the body and thus are taxonomically informative.
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