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| 2. |
- Royer, P., et al.
(författare)
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PACS and SPIRE spectroscopy of the red supergiant VY CMa
- 2010
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518, s. L145-
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Tidskriftsartikel (refereegranskat)abstract
- With a luminosity > 10(5) L-circle dot and a mass-loss rate of similar to 2 x 10(-4) M-circle dot yr(-1), the red supergiant VY CMa truly is a spectacular object. Because of its extreme evolutionary state, it could explode as supernova any time. Studying its circumstellar material, into which the supernova blast will run, provides interesting constraints on supernova explosions and on the rich chemistry taking place in such complex circumstellar envelopes. We have obtained spectroscopy of VY CMa over the full wavelength range offered by the PACS and SPIRE instruments of Herschel, i.e. 55-672 micron. The observations show the spectral fingerprints of more than 900 spectral lines, of which more than half belong to water. In total, we have identified 13 different molecules and some of their isotopologues. A first analysis shows that water is abundantly present, with an ortho-to-para ratio as low as similar to 1.3:1, and that chemical non-equilibrium processes determine the abundance fractions in the inner envelope.
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| 3. |
- Renders, B., et al.
(författare)
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Distributed generation and the voltage profile on distribution feeders during voltage dips
- 2010
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Ingår i: Electric power systems research. - : Elsevier BV. - 0378-7796 .- 1873-2046. ; 80:12, s. 1452-1458
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Tidskriftsartikel (refereegranskat)abstract
- The presence of distributed generators in the distribution network results in an increase of the voltage magnitude close to these generators, during a fault elsewhere in the distribution system or in the transmission system. This voltage dip mitigation capability of converter-connected distributed generation (DG) units is dependent on the control strategy of the converter. To compare the influence of different types of converter-connected distributed generators on the voltage profile along distribution feeders during a fault, the quantity,"voltage ratio" is used. This voltage ratio is obtained by division of the voltage during the voltage dip by the voltage just before the voltage dip. The different converter types are modelled, and the influence on the voltage ratio is analysed.
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| 4. |
- Villard, Eric, et al.
(författare)
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A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy
- 2011
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 32:9, s. 1065-1076
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Tidskriftsartikel (refereegranskat)abstract
- Aims: Dilated cardiomyopathy (DCM) is a major cause of heart failure with a high familial recurrence risk. So far, the genetics of DCM remains largely unresolved. We conducted the first genome-wide association study (GWAS) to identify loci contributing to sporadic DCM.Methods and results: One thousand one hundred and seventy-nine DCM patients and 1108 controls contributed to the discovery phase. Pools of DNA stratified on disease status, population, age, and gender were constituted and used for testing association of DCM with 517 382 single nucleotide polymorphisms (SNPs). Three DCM-associated SNPs were confirmed by individual genotyping (P < 5.0 10−7), and two of them, rs10927875 and rs2234962, were replicated in independent samples (1165 DCM patients and 1302 controls), with P-values of 0.002 and 0.009, respectively. rs10927875 maps to a region on chromosome 1p36.13 which encompasses several genes among which HSPB7 has been formerly suggested to be implicated in DCM. The second identified locus involves rs2234962, a non-synonymous SNP (c.T757C, p. C151R) located within the sequence of BAG3 on chromosome 10q26. To assess whether coding mutations of BAG3 might cause monogenic forms of the disease, we sequenced BAG3 exons in 168 independent index cases diagnosed with familial DCM and identified four truncating and two missense mutations. Each mutation was heterozygous, present in all genotyped relatives affected by the disease and absent in a control group of 347 healthy individuals, strongly suggesting that these mutations are causing the disease.Conclusion: This GWAS identified two loci involved in sporadic DCM, one of them probably implicates BAG3. Our results show that rare mutations in BAG3 contribute to monogenic forms of the disease, while common variant(s) in the same gene are implicated in sporadic DCM.
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