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- Doornenbal, P., et al.
(författare)
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Spectroscopy of 32Ne and the "œIsland of Inversion"
- 2009
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Ingår i: Physical Review Letters. - American Physical Society. - 0031-9007 .- 1079-7114. ; 103:3, s. 032501-1-032501-4
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Tidskriftsartikel (refereegranskat)abstract
- We report on the first spectroscopic study of the N = 22 nucleus 32Ne at the newly completed RIKEN Radioactive Ion Beam Factory. A single γ-ray line with an energy of 722(9) keV was observed in both inelastic scattering of a 226 MeV=u 32Ne beam on a carbon target and proton removal from 33Na at 245 MeV=u. This transition is assigned to the deexcitation of the first Jπ = 2+ state in 32Ne to the 0+ ground state. Interpreted through comparison with state-of-the-art shell-model calculations, the low excitation energy demonstrates that the ‘‘island of inversion’’ extends to at least N = 22 for the Ne isotopes.
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| 2. |
- Isobe, T, et al.
(författare)
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Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia
- 2022
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 4501-
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Tidskriftsartikel (refereegranskat)abstract
- KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation array analysis, whole exome and targeted deep sequencing on 84 infants with KMT2A-rearranged leukemia. Our multi-omics clustering followed by single-sample and single-cell inference of hematopoietic differentiation establishes five robust integrative clusters (ICs) with different master transcription factors, fusion partners and corresponding stages of B-lymphopoietic and early hemato-endothelial development: IRX-type differentiated (IC1), IRX-type undifferentiated (IC2), HOXA-type MLLT1 (IC3), HOXA-type MLLT3 (IC4), and HOXA-type AFF1 (IC5). Importantly, our deep mutational analysis reveals that the number of RAS pathway mutations predicts prognosis and that the most refractory subgroup of IC2 possesses 100% frequency and the heaviest burden of RAS pathway mutations. Our findings highlight the previously under-appreciated intra- and inter-patient heterogeneity of KMT2A-rearranged infant ALL and provide a rationale for the future development of genomics-guided risk stratification and individualized therapy.
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| 5. |
- Winnberg, A., et al.
(författare)
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CO in OH/IR stars close to the Galactic centre
- 2009
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 497, s. 177-181
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Tidskriftsartikel (refereegranskat)abstract
- Aims: A pilot project has been carried out to measure circumstellar CO emission from three OH/IR stars close to the Galactic centre. The intention was to find out whether it would be possible to conduct a large-scale survey for mass-loss rates using, for example, the Atacama large millimeter array (ALMA). Such a survey would increase our understanding of the evolution of the Galactic bulge. Methods: Two millimetre-wave instruments were used: the Nobeyama Millimeter Array at 115 GHz and the Submillimeter Array at 230 GHz. An interferometer is necessary as a “spatial filter” in this region of space because of the confusion with interstellar CO emission. Results: Towards two of the stars, CO emission was detected with positions and radial velocities coinciding within the statistical errors with the corresponding data of the associated OH sources. However, for one of the stars the line profile is not what one expects for an unresolved expanding circumstellar envelope. We believe that this CO envelope is partially resolved and that this star therefore is a foreground star not belonging to the bulge. Conclusions: The results of the observations have shown that it is possible to detect line profiles of circumstellar CO from late-type stars both within and in the direction of the Galactic bulge. ALMA will be able to detect CO emission in short integrations with sensitivity sufficient to estimate mass-loss rates from a large number of such stars.
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