| 1. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 4. |
- Demidov, V. I., et al.
(författare)
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Electric probes for plasmas : The link between theory and instrument
- 2002
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 73:10, s. 3409-3439
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Forskningsöversikt (refereegranskat)abstract
- Electric probe methods for diagnostics of plasmas are reviewed with emphasis on the link between the appropriate probe theories and the instrumental design. The starting point is an elementary discussion of the working principles and a discussion of the physical quantities that can be measured by the probe method. This is followed by a systematic classification of the various regimes of probe operation and a summary of theories and methods for measurements of charged particle distributions. Application of a single probe and probe clusters for measurements of fluid observables is discussed. Probe clusters permit both instantaneous and time-averaged measurements without sweeping the probe voltage. Two classes of applications are presented as illustrations of the methods reviewed. These are measurements of cross sections and collision frequencies (plasma electron spectroscopy), and measurements of fluctuations and anomalous transport in magnetized plasma.
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| 5. |
- Demidov, V. I., et al.
(författare)
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Reducing influence of ion current on measurements of electron energy distributions in collisional plasmas
- 2001
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 72:11, s. 4106-4109
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Tidskriftsartikel (refereegranskat)abstract
- A method for reducing the influence of ion current on probe measurements of electron velocity distributions in plasmas has been developed and tested in noble gas afterglow plasmas. It is valid for diffusive transport of ions to the probe. Experiments have demonstrated high accuracy of the proposed method.
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| 6. |
- Demidov, V. I., et al.
(författare)
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The analysis of probe I-V characteristics in a magnetized low-temperature plasma
- 2001
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Ingår i: Contributions to Plasma Physics. - 0863-1042 .- 1521-3986. ; 41:5, s. 443-448
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Tidskriftsartikel (refereegranskat)abstract
- The validity of probe theories based on the classical electron transport to probes in low-temperature magnetized plasma of the toroidal device `Blaamann has been demonstrated. The analysis was carried out for the conditions when global transport of charged particles in the device is anomalous, namely for magnetic field up to 0.3 T and pressure range 0.1 - 1 Pa. It was shown also that for the magnetic field larger than 0.1 T probes longer than 15 mm provide electron saturation current practically independent of probe potential, hence more accurate measurements of the plasma parameters. The experiments have revealed that application of long probes oriented parallel to the magnetic field may cause an anomaly of the I-V characteristics in the sense that a local increase of the electron current appears near the plasma potential.
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| 7. |
- Demidov, V. V., et al.
(författare)
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Magnetic anisotropy in strained manganite films and bicrystal junctions
- 2013
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 113:16
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Tidskriftsartikel (refereegranskat)abstract
- Transport and magnetic properties of La0.67Sr0.33MnO3 (LSMO) manganite thin films and bicrystal junctions were investigated. Epitaxial manganite films were grown on SrTiO3, LaAlO3, NdGaO3 (NGO), and (LaAlO3)(0.3) + (Sr2AlTaO6)(0.7) substrates, and their magnetic anisotropy were determined by two independent techniques of magnetic resonance spectroscopy. It was demonstrated that by using these techniques, a small (0.3%) anisotropy of crystal structure at the (110) surface plane of the orthorhombic NGO substrate leads to uniaxial magnetic anisotropy of the films in the plane of the substrate at least at the room temperature. It was found that on vicinal NGO substrates, the value of magnetic anisotropy strength can be varied in the range 100-200 Oe at T = 295 K by changing the substrate vicinal angle from 0 degrees to 25 degrees. Measurement of the magnetic anisotropy of manganite bicrystal junction demonstrated the presence of two ferromagnetic spin subsystems for both types of bicrystal boundaries with tilting of basal plane of manganite tilted bicrystal (TB-junction) and with rotation of crystallographic axes (RB-junction) used for comparison. The magnetoresistance of TB-junctions increases with decreasing temperature and the misorientation angle. Variation of bicrystal misorientation angle does not lead to change of misorientation of easy magnetic axes in the film parts forming TB-junction. Analysis of the voltage dependencies of bicrystal junction conductivity show that the low value of the magnetoresistance for the LSMO bicrystal junctions can be caused by two scattering mechanisms. The first one is the spin-flip of spin-polarized carriers due to the strong electron-electron interactions in a disordered layer at the bicrystal boundary at low temperatures and the second one is spin-flip by antiferromagnetic magnons at high temperatures.
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| 8. |
- Demidov, V. V., et al.
(författare)
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Magnetic Anisotropy of Strained Epitaxial Manganite Films
- 2011
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Ingår i: Journal of Experimental and Theoretical Physics. - : Pleiades Publishing Ltd. - 1090-6509 .- 1063-7761. ; 112:5, s. 825-832
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Tidskriftsartikel (refereegranskat)abstract
- The in-plane magnetic anisotropy of epitaxial La(0.7)Sr(0.3)MnO(3) (LSMO) films is studied at room temperature by the following three independent techniques: magnetooptical Kerr effect, ferromagnetic resonance at a frequency of 9.61 GHz, and recording of absorption spectra of electromagnetic radiation at a frequency of 290.6 MHz. The films are deposited onto NdGaO(3) (NGO) substrates in which the (110) NGO plane is tilted at an angle of 0-25.7 degrees to the substrate plane. The uniaxial magnetic anisotropy induced by the strain of the film is found to increase with the tilt angle of the (110) NGO plane. A model is proposed to describe the change in the magnetic anisotropy energy with the tilt angle. A sharp increase in the radio-frequency absorption in a narrow angular range of a dc magnetic field near a hard magnetization axis is detected The anisotropy parameters of the LSMO films grown on (110) NGO, (001) SrTiO(3), and (001)[(LaAlO(3))(0.3) + (Sr(2)AlTaO(6))(0.7)] substrates are compared.
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| 9. |
- Hubberten, HW, et al.
(författare)
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The periglacial climate and environment in northern Eurasia during the Last Glaciation
- 2004
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Ingår i: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791. ; 23:11-13, s. 1333-1357
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Forskningsöversikt (refereegranskat)abstract
- This paper summarizes the results of studies of the Late Weichselian periglacial environments carried out in key areas of northern Eurasia by several QUEEN teams (European Science Foundation (ESF) programme: "Quaternary Environment of the Eurasian North"). The palaeoglaciological boundary conditions are defined by geological data on timing and extent of the last glaciation obtained in the course of the EU funded project "Eurasian Ice Sheets". These data prove beyond any doubt, that with the exception of the northwestern fringe of the Taymyr Peninsula, the rest of the Eurasian mainland and Severnaya Zemlya were not affected by the Barents-Kara Sea fee Sheet during the Last Glacial Maximum (LGM). Inversed modelling based on these results shows that a progressive cooling which started around 30 ka BP, caused ice growth in Scandinavia and the northwestern areas of the Barents-Kara Sea shelf, due to a maritime climate with relatively high precipitation along the western flank of the developing ice sheets. In the rest of the Eurasian Arctic extremely low precipitation rates (less than 50 mm yr(-1)), did not allow ice sheet growth in spite of the very cold temperatures. Palaeoclimatic and palaeoenvironmental conditions for the time prior to, during, and after the LGM have been reconstructed for the non-glaciated areas around the LGM ice sheet with the use of faunal and vegetation records, permafrost, eolian sediments, alluvial deposits and other evidences. The changing environment, from interstadial conditions around 30 ka BP to a much colder and drier environment at the culmination of the LGM at 20-15 ka BP, and the beginning of warming around 15 ka BP have been elaborated from the field data, which fits well with the modelling results. (C) 2003 Elsevier Ltd. All rights reserved.
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| 10. |
- Ovsyannikov, Gennady, 1948, et al.
(författare)
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Magnetotransport characteristics of strained La0.7Sr0.3MnO3 epitaxial manganite films
- 2009
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Ingår i: Journal of Experimental and Theoretical Physics. - 1090-6509 .- 1063-7761. ; 108:1, s. 48-55
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Tidskriftsartikel (refereegranskat)abstract
- The electrical and magnetic characteristics of La0.7Sr0.3MnO3 (LSMO) epitaxial manganite films are investigated by different methods under conditions when the crystal structure is strongly strained as a result of mismatch between the lattice parameters of the LSMO crystal and the substrate. Substrates with lattice parameters larger and smaller than the nominal lattice parameter of the LSMO crystal are used in experiments. It is shown that the behavior of the temperature dependence of the electrical resistance for the films in the low-temperature range does not depend on the strain of the film and agrees well with the results obtained from the calculations with allowance made for the interaction of electrons with magnetic excitations in the framework of the double-exchange model for systems with strongly correlated electronic states. Investigations of the magneto- optical Kerr effect have revealed that an insignificant (0.3%) orthorhombic distortion of the cubic lattice in the plane of the NdGaO3(110) substrate leads to uniaxial anisotropy of the magnetization of the film, with the easy-magnetization axis lying in the substrate plane. However, LSMO films on substrates (((LaAlO3)(0.3)+(Sr2AlTaO6)(0.7))(001)) ensuring minimum strain of the films exhibit a biaxial anisotropy typical of cubic crystals. The study of the ferromagnetic resonance lines at a frequency of 9.76 GHz confirms the results of magnetooptical investigations and indicates that the ferromagnetic phase in the LSMO films is weakly inhomogeneous.
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