| 1. |
- Francardo, Veronica, et al.
(författare)
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Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease
- 2019
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Ingår i: Neurotherapeutics. - : Springer Science and Business Media LLC. - 1933-7213 .- 1878-7479. ; 16:2, s. 465-479
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Tidskriftsartikel (refereegranskat)abstract
- Pridopidine is a small molecule in clinical development for the treatment of Huntington’s disease. It was recently found to have high binding affinity to the sigma-1 receptor, a chaperone protein involved in cellular defense mechanisms and neuroplasticity. Here, we have evaluated the neuroprotective and neurorestorative effects of pridopidine in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of parkinsonism in mice. By 5 weeks of daily administration, a low dose of pridopidine (0.3 mg/kg) had significantly improved deficits in forelimb use (cylinder test, stepping test) and abolished the ipsilateral rotational bias typical of hemiparkinsonian animals. A higher dose of pridopidine (1 mg/kg) significantly improved only the rotational bias, with a trend towards improvement in forelimb use. The behavioral recovery induced by pridopidine 0.3 mg/kg was accompanied by a significant protection of nigral dopamine cell bodies, an increased dopaminergic fiber density in the striatum, and striatal upregulation of GDNF, BDNF, and phosphorylated ERK1/2. The beneficial effects of pridopidine 0.3 mg/kg were absent in 6-OHDA-lesioned mice lacking the sigma-1 receptor. Pharmacokinetic data confirmed that the effective dose of pridopidine reached brain concentrations sufficient to bind S1R. Our results are the first to show that pridopidine promotes functional neurorestoration in the damaged nigrostriatal system acting via the sigma-1 receptor.
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| 2. |
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| 3. |
- Lyamin, Nikita, 1989-, et al.
(författare)
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AI-Based Malicious Network Traffic Detection in VANETs
- 2018
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Ingår i: IEEE Network. - Piscataway, NJ : IEEE. - 0890-8044 .- 1558-156X. ; 32:6, s. 15-21
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Tidskriftsartikel (refereegranskat)abstract
- Inherent unreliability of wireless communications may have crucial consequences when safety-critical C-ITS applications enabled by VANETs are concerned. Although natural sources of packet losses in VANETs such as network traffic congestion are handled by decentralized congestion control (DCC), losses caused by malicious interference need to be controlled too. For example, jamming DoS attacks on CAMs may endanger vehicular safety, and first and foremost are to be detected in real time. Our first goal is to discuss key literature on jamming modeling in VANETs and revisit some existing detection methods. Our second goal is to present and evaluate our own recent results on how to address the real-time jamming detection problem in V2X safety-critical scenarios with the use of AI. We conclude that our hybrid jamming detector, which combines statistical network traffic analysis with data mining methods, allows the achievement of acceptable performance even when random jitter accompanies the generation of CAMs, which complicates the analysis of the reasons for their losses in VANETs. The use case of the study is a challenging platooning C-ITS application, where V2X-enabled vehicles move together at highway speeds with short inter-vehicle gaps.
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| 4. |
- Lyamin, Nikita, 1989-, et al.
(författare)
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Real-time jamming DoS detection in safety-critical V2V C-ITS using data mining
- 2019
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Ingår i: IEEE Communications Letters. - Piscataway, NJ : IEEE. - 1089-7798 .- 1558-2558. ; 23:3, s. 442-445
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Tidskriftsartikel (refereegranskat)abstract
- A data mining-based method for real-time detection of radio jamming Denial-of-Service (DoS) attacks in IEEE 802.11p vehicle-to-vehicle (V2V) communications is proposed. The method aims at understanding the reasons for losses of periodic cooperative awareness messages (CAM) exchanged by vehicles in a platoon. Detection relies on a knowledge of IEEE 802.11p protocols rules as well as on historical observation of events in the V2V channel. In comparison to the state-of-theart method, the proposed method allows operating under the realistic assumption of random jitter accompanying every CAM transmission. The method is evaluated for two jamming models: random and ON-OFF.
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| 5. |
- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 6. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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