| 1. |
- Underwood, J, et al.
(författare)
-
Validation of a Novel Multivariate Method of Defining HIV-Associated Cognitive Impairment
- 2019
-
Ingår i: Open forum infectious diseases. - : Oxford University Press (OUP). - 2328-8957. ; 6:6, s. ofz198-
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe optimum method of defining cognitive impairment in virally suppressed people living with HIV is unknown. We evaluated the relationships between cognitive impairment, including using a novel multivariate method (NMM), patient– reported outcome measures (PROMs), and neuroimaging markers of brain structure across 3 cohorts.MethodsDifferences in the prevalence of cognitive impairment, PROMs, and neuroimaging data from the COBRA, CHARTER, and POPPY cohorts (total n = 908) were determined between HIV-positive participants with and without cognitive impairment defined using the HIV-associated neurocognitive disorders (HAND), global deficit score (GDS), and NMM criteria.ResultsThe prevalence of cognitive impairment varied by up to 27% between methods used to define impairment (eg, 48% for HAND vs 21% for NMM in the CHARTER study). Associations between objective cognitive impairment and subjective cognitive complaints generally were weak. Physical and mental health summary scores (SF-36) were lowest for NMM-defined impairment (P < .05).There were no differences in brain volumes or cortical thickness between participants with and without cognitive impairment defined using the HAND and GDS measures. In contrast, those identified with cognitive impairment by the NMM had reduced mean cortical thickness in both hemispheres (P < .05), as well as smaller brain volumes (P < .01). The associations with measures of white matter microstructure and brain-predicted age generally were weaker.ConclusionDifferent methods of defining cognitive impairment identify different people with varying symptomatology and measures of brain injury. Overall, NMM-defined impairment was associated with most neuroimaging abnormalities and poorer self-reported health status. This may be due to the statistical advantage of using a multivariate approach.
|
|
| 2. |
|
|
| 3. |
- Axelsson, Malin, et al.
(författare)
-
Lived experiences: a focus group pilot study within the MentALLY project of mental healthcare among European users
- 2020
-
Ingår i: BMC Health Services Research. - : Springer Science and Business Media LLC. - 1472-6963. ; 20:1
-
Tidskriftsartikel (refereegranskat)abstract
- BackgroundMental healthcare is an important component in societies' response to mental health problems. Although the World Health Organization highlights availability, accessibility, acceptability and quality of healthcare as important cornerstones, many Europeans lack access to mental healthcare of high quality. Qualitative studies exploring mental healthcare from the perspective of people with lived experiences would add to previous research and knowledge by enabling in-depth understanding of mental healthcare users, which may be of significance for the development of mental healthcare. Therefore, the aim of the current study was to describe experiences of mental healthcare among adult Europeans with mental health problems.MethodIn total, 50 participants with experiences of various mental health problems were recruited for separate focus group interviews in each country. They had experiences from both the private and public sectors, and with in- and outpatient mental healthcare. The focus group interviews (N=7) were audio recorded, transcribed verbatim and analysed through thematic analysis. The analysis yielded five themes and 13 subthemes.ResultsThe theme Seeking and trying to find help contained three subthemes describing personal thresholds for seeking professional help, not knowing where to get help, and the importance of receiving help promptly. The theme Awaiting assessment and treatment contained two subthemes including feelings of being prioritized or not and feelings of being abandoned during the often-lengthy referral process. The theme Treatment: a plan with individual parts contained three subthemes consisting of demands for tailored treatment plans in combination with medications and human resources and agreement on treatment. The theme Continuous and respectful care relationship contained two subthemes describing the importance of continuous care relationships characterised by empathy and respect. The theme Suggestions for improvements contained three subthemes highlighting an urge to facilitate care contacts and to increase awareness of mental health problems and a wish to be seen as an individual with potential.ConclusionFacilitating contacts with mental healthcare, a steady contact during the referral process, tailored treatment and empathy and respect are important aspects in efforts to improve mental healthcare. Recommendations included development of collaborative practices between stakeholders in order to increase general societal awareness of mental health problems.
|
|
| 4. |
|
|
| 5. |
- Torchio, R., et al.
(författare)
-
Structure and magnetism of cobalt at high pressure and low temperature
- 2016
-
Ingår i: PHYSICAL REVIEW B. - 2469-9950. ; 94:2
-
Tidskriftsartikel (refereegranskat)abstract
- The magnetic and structural properties of cobalt were investigated under high pressure (160 GPa) and low temperature (50 K), by synchrotron K-edge x-ray magnetic circular dichroism and x-ray diffraction. A quasihydrostatic equation of state was measured up to 160 GPa. We found that uniaxial stress plays a role in the hexagonal close packed-face centered cubic (hcp-fcc) structural transition pressure. Also, our data provide the first experimental evidence that changes of the c/a ratio pressure derivative are related to the magnetic behavior. The complete extinction of ferromagnetism is observed above 130 GPa in a mixed hcp-fcc phase with no recovery upon cooling to 50 K, indicating that cobalt at 150 GPa is very likely nonmagnetic, i.e., characterized by zero local spin polarization. Density functional theory calculations point out that the K-edge x-ray magnetic circular dichroism (XMCD) signal is related to the 4p orbital moment rather than to the total spin moment and allow us to get a deeper insight into the K-edge XMCD measurements interpretation. The combination of novel theoretical results and experimental outputs provides a detailed scenario of the structural and magnetic properties of cobalt at these extreme conditions answering some previously unsolved issues.
|
|
| 6. |
- Desmyter, L., et al.
(författare)
-
Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death
- 2004
-
Ingår i: Experimental Gerontology. - : Elsevier BV. - 0531-5565. ; 39:5, s. 707-715
-
Tidskriftsartikel (refereegranskat)abstract
- Ferritin is one of the major eukaryotic proteins involved in regulating iron metabolism and maintaining iron homeostasis. However, Saccaromyces cerevisiae is an exception, possessing no ferritin and using other means to store excess iron. The only potential iron storage protein identified in yeast so far is the homologue of human frataxin (YFH1p). In this study, we found that dysfunction of yeast frataxin shortens mean lifespan by 49% compared to the WT control. Interestingly, the human ferritin L gene can, at least partially, complement the function of yeast frataxin, extending lifespan and protecting cells from death induced by oxidative stress or excess iron. Our findings indicate that ferritin L can perform functions in yeast that are similar to its functions in mammals, and suggest that common mechanisms may exist for preventing iron and oxidative damage in single- and multi-cellular eukaryotic organisms. Clearly, elucidation of the function of human ferritin in yeast would help in gaining a better understanding the molecular basis of iron storage diseases
|
|
| 7. |
|
|
