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- Savarino, E., et al.
(author)
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Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility
- 2022
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In: United European Gastroenterology Journal. - : Wiley. - 2050-6406 .- 2050-6414. ; 10:6, s. 556-584
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Journal article (peer-reviewed)abstract
- Irritable bowel syndrome with diarrhoea (IBS-D) and functional diarrhoea (FDr) are the two major functional bowel disorders characterized by diarrhoea. In spite of their high prevalence, IBS-D and FDr are associated with major uncertainties, especially regarding their optimal diagnostic work-up and management. A Delphi consensus was performed with experts from 10 European countries who conducted a literature summary and voting process on 31 statements. Quality of evidence was evaluated using the grading of recommendations, assessment, development, and evaluation criteria. Consensus (defined as >80% agreement) was reached for all the statements. The panel agreed with the potential overlapping of IBS-D and FDr. In terms of diagnosis, the consensus supports a symptom-based approach also with the exclusion of alarm symptoms, recommending the evaluation of full blood count, C-reactive protein, serology for coeliac disease, and faecal calprotectin, and consideration of diagnosing bile acid diarrhoea. Colonoscopy with random biopsies in both the right and left colon is recommended in patients older than 50 years and in presence of alarm features. Regarding treatment, a strong consensus was achieved for the use of a diet low fermentable oligo-, di-, monosaccharides and polyols, gut-directed psychological therapies, rifaximin, loperamide, and eluxadoline. A weak or conditional recommendation was achieved for antispasmodics, probiotics, tryciclic antidepressants, bile acid sequestrants, 5-hydroxytryptamine-3 antagonists (i.e. alosetron, ondansetron, or ramosetron). A multinational group of European experts summarized the current state of consensus on the definition, diagnosis, and management of IBS-D and FDr.
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| 2. |
- Picone, P., et al.
(author)
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Ionizing radiation-engineered nanogels as insulin nanocarriers for the development of a new strategy for the treatment of Alzheimer’s disease
- 2016
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In: Biomaterials. - : Elsevier. - 0142-9612 .- 1878-5905. ; 80, s. 179-194
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Journal article (peer-reviewed)abstract
- A growing body of evidence shows the protective role of insulin in Alzheimer’s disease (AD). A nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for Alzheimer’s Disease (AD), is designed and synthetized. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by ionizing radiation is chosen as substrate for the covalent attachment of insulin or fluorescent molecules relevant for its characterization. Biocompatibility and hemocompatibility of the naked carrier is demonstrated. The insulin conjugated to the NG (NG-In) is protected by protease degradation and able to bind to insulin receptor (IR), as demonstrated by immunofluorescence measurements showing colocalization of NG-InFITC with IR. Moreover, after binding to the receptor, NG-In is able to trigger insulin signaling via AKT activation. Neuroprotection of NG-In against dysfunction induced by amyloid β (Aβ), a peptide mainly involved in AD, is verified. Finally, the potential of NG-In to be efficiently transported across the Blood Brain Barrier (BBB) is demonstrated. All together these results indicate that the synthesized NG-In is a suitable vehicle system for insulin deliver in biomedicine and a very promising tool to develop new therapies for neurodegenerative diseases.
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| 3. |
- Buccolieri, R., et al.
(author)
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Flow and pollutant dispersion within the canal grande channel in venice (Italy) via CFD techniques
- 2010
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In: HARMO 2010 - Proceedings of the 13th International Conference on Harmonisation within Atmospheric Dispersion Modelling for Regulatory Purposes. ; , s. 760-764
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Conference paper (peer-reviewed)abstract
- The present paper is aimed at the analysis of flow and pollutant dispersion in a portion of the Canal Grande (Grand Canal) in Venice (Italy) by means of both Computational Fluid Dynamics (CFD) FLUENT simulations and wind tunnel experiments performed at the University of Gävle (Sweden). For this application, Canal Grande can be viewed as a sort of street canyon where the bottom surface is water and bus boat emissions are the major source of pollution. Numerical investigations were made to assess the effect of the water surface on air flow and pollutant concentrations in the atmosphere. One of the challenges has been to deal with the interface between two immiscible fluids which requires ad-hoc treatment of the wall in terms of the numerical scheme adopted and the grid definition which needs to be much finer than in typical numerical airflow simulations in urban street canyons. Preliminary results have shown that the presence of water at the bottom of the street canyon modifies airflow and turbulence structure with direct consequences on concentration distribution within the domain.
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