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- Bjurström, Martin F., et al.
(författare)
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Central nervous system monoaminergic activity in hip osteoarthritis patients with disabling pain : associations with pain severity and central sensitization
- 2022
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Ingår i: Pain Reports. - 2471-2531. ; 7:1, s. 988-988
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Monoaminergic activity modulates nociceptive transmission in the central nervous system (CNS). Although pain is the most disabling symptom of osteoarthritis (OA), limited knowledge exists regarding the CNS mechanisms that amplify pain and drive sensitization processes in humans.Objectives:The main objective of this study was to evaluate associations between cerebrospinal fluid (CSF) monoamine metabolites, pain severity, and central sensitization in patients with OA undergoing total hip arthroplasty (THA).Methods:Patients with OA (n = 52) and pain-free controls (n = 30) provided CSF samples for measurement of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), noradrenaline (3-methoxy-4-hydroxyphenylglycol [HMPG]), and dopamine (homovanillic acid [HVA]) monoamine metabolites. Patients with OA completed longitudinal evaluation of pain using clinical measures and quantitative sensory testing.Results:Patients with OA had higher HMPG levels when compared with controls (P = 0.036). Within patients with OA undergoing THA, higher 5-HIAA and HVA levels were consistently associated with higher preoperative pain severity. Higher concentrations of 5-HIAA and HVA were also associated with lower conditioned pain modulation levels, whereas higher HMPG levels were linked to more efficient conditioned pain modulation. Patients with higher levels of CSF HVA exhibited increased pressure pain sensitivity (arm pressure pain detection threshold < 250 kPa vs ≥ 250 kPa, P = 0.042). Higher preoperative levels of CSF 5-HIAA predicted poorer pain control 6 months postoperatively (brief pain inventory pain severity; adjusted β = 0.010, 95% CI 0.001-0.019).Conclusions:In OA patients with disabling pain, higher CSF levels of serotonin and dopamine metabolites are associated with increased pain severity and central sensitization. Increased noradrenergic activity may be associated with more efficient pain inhibitory capacity.
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| 2. |
- Nielsen, Kristian S., et al.
(författare)
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The role of high-socioeconomic-status people in locking in or rapidly reducing energy-driven greenhouse gas emissions
- 2021
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Ingår i: Nature Energy. - : Springer Science and Business Media LLC. - 2058-7546. ; 6:11, s. 1011-1016
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Tidskriftsartikel (refereegranskat)abstract
- People with high socioeconomic status disproportionally affect energy-driven greenhouse gas emissions directly through their consumption and indirectly through their financial and social resources. However, few climate change mitigation initiatives have targeted this population segment, and the potential of such initiatives remains insufficiently researched. In this Perspective, we analyse key characteristics of high-socioeconomic-status people and explore five roles through which they have a disproportionate impact on energy-driven greenhouse gas emissions and potentially on climate change mitigation, namely as consumers, investors, role models, organizational participants and citizens. We examine what is known about their disproportionate impact via consumption and explore their potential influence on greenhouse gas emissions through all five roles. We suggest that future research should focus on strategies to reduce greenhouse gas emissions by high-socioeconomic-status people and to align their investments, organizational choices and actions as social and political change agents with climate change mitigation goals.
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| 3. |
- White, Helen E., et al.
(författare)
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Standardization of molecular monitoring of CML : results and recommendations from the European treatment and outcome study
- 2022
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Ingår i: Leukemia. - : Springer Nature. - 0887-6924 .- 1476-5551. ; 36:7, s. 1834-1842
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Tidskriftsartikel (refereegranskat)abstract
- Standardized monitoring of BCR::ABL1 mRNA levels is essential for the management of chronic myeloid leukemia (CML) patients. From 2016 to 2021 the European Treatment and Outcome Study for CML (EUTOS) explored the use of secondary, lyophilized cell-based BCR::ABL1 reference panels traceable to the World Health Organization primary reference material to standardize and validate local laboratory tests. Panels were used to assign and validate conversion factors (CFs) to the International Scale and assess the ability of laboratories to assess deep molecular response (DMR). The study also explored aspects of internal quality control. The percentage of EUTOS reference laboratories (n = 50) with CFs validated as optimal or satisfactory increased from 67.5% to 97.6% and 36.4% to 91.7% for ABL1 and GUSB, respectively, during the study period and 98% of laboratories were able to detect MR4.5 in most samples. Laboratories with unvalidated CFs had a higher coefficient of variation for BCR::ABL1(IS) and some laboratories had a limit of blank greater than zero which could affect the accurate reporting of DMR. Our study indicates that secondary reference panels can be used effectively to obtain and validate CFs in a manner equivalent to sample exchange and can also be used to monitor additional aspects of quality assurance.
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