| 1. |
- Nelson, G., et al.
(författare)
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QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy
- 2021
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Ingår i: Journal of Microscopy. - : Wiley. - 0022-2720 .- 1365-2818. ; 284:1, s. 56-73
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Tidskriftsartikel (refereegranskat)abstract
- A modern day light microscope has evolved from a tool devoted to making primarily empirical observations to what is now a sophisticated , quantitative device that is an integral part of both physical and life science research. Nowadays, microscopes are found in nearly every experimental laboratory. However, despite their prevalent use in capturing and quantifying scientific phenomena, neither a thorough understanding of the principles underlying quantitative imaging techniques nor appropriate knowledge of how to calibrate, operate and maintain microscopes can be taken for granted. This is clearly demonstrated by the well-documented and widespread difficulties that are routinely encountered in evaluating acquired data and reproducing scientific experiments. Indeed, studies have shown that more than 70% of researchers have tried and failed to repeat another scientist's experiments, while more than half have even failed to reproduce their own experiments. One factor behind the reproducibility crisis of experiments published in scientific journals is the frequent underreporting of imaging methods caused by a lack of awareness and/or a lack of knowledge of the applied technique. Whereas quality control procedures for some methods used in biomedical research, such as genomics (e.g. DNA sequencing, RNA-seq) or cytometry, have been introduced (e.g. ENCODE), this issue has not been tackled for optical microscopy instrumentation and images. Although many calibration standards and protocols have been published, there is a lack of awareness and agreement on common standards and guidelines for quality assessment and reproducibility. In April 2020, the QUality Assessment and REProducibility for instruments and images in Light Microscopy (QUAREP-LiMi) initiative was formed. This initiative comprises imaging scientists from academia and industry who share a common interest in achieving a better understanding of the performance and limitations of microscopes and improved quality control (QC) in light microscopy. The ultimate goal of the QUAREP-LiMi initiative is to establish a set of common QC standards, guidelines, metadata models and tools, including detailed protocols, with the ultimate aim of improving reproducible advances in scientific research. This White Paper (1) summarizes the major obstacles identified in the field that motivated the launch of the QUAREP-LiMi initiative; (2) identifies the urgent need to address these obstacles in a grassroots manner, through a community of stakeholders including, researchers, imaging scientists, bioimage analysts, bioimage informatics developers, corporate partners, funding agencies, standards organizations, scientific publishers and observers of such; (3) outlines the current actions of the QUAREP-LiMi initiative and (4) proposes future steps that can be taken to improve the dissemination and acceptance of the proposed guidelines to manage QC. To summarize, the principal goal of the QUAREP-LiMi initiative is to improve the overall quality and reproducibility of light microscope image data by introducing broadly accepted standard practices and accurately captured image data metrics.
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| 2. |
- Chiesa, Marco, 1987-, et al.
(författare)
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Inter-domain networking innovation on steroids : Empowering IXPs with SDN capabilities
- 2016
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Ingår i: IEEE Communications Magazine. - : Institute of Electrical and Electronics Engineers (IEEE). - 0163-6804 .- 1558-1896. ; 54:10, s. 102-108
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Tidskriftsartikel (refereegranskat)abstract
- While innovation in inter-domain routing has remained stagnant for over a decade, Internet exchange points (IXPs) are consolidating their role as economically advantageous interconnection points for reducing path latencies and exchanging ever increasing amounts of traffic. As such, IXPs appear as a natural place to foster network innovation and assess the benefits of SDN, a recent technological trend that has already boosted innovation within data center networks. In this article, we give a comprehensive overview of use cases for SDN at IXPs, which leverage the superior vantage point of an IXP to introduce advanced features like load balancing and DDoS mitigation. We discuss the benefits of SDN solutions by analyzing real-world data from one of the largest IXPs. We also leverage insights into IXP operations to shape benefits not only for members but also for operators.
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| 3. |
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| 4. |
- Dietzel, C., et al.
(författare)
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SDN-enabled traffic engineering and advanced blackholing at IXPs
- 2017
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Ingår i: SOSR 2017 - Proceedings of the 2017 Symposium on SDN Research. - New York, NY, USA : ACM. ; , s. 181-182
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Konferensbidrag (refereegranskat)abstract
- While the clean slate approach proposed by Software Defined Networking (SDN) promises radical changes in the stagnant state of network management, SDN innovation has not gone beyond the intra-domain level. For the inter-domain ecosystem to benefit from the advantages of SDN, Internet Exchange Points (IXPs) are the ideal place: a central interconnection hub through which a large share of the Internet can be affected. In this demo, we showcase the ENDEAVOUR platform: a new software defined exchange approach readily deployable in commercial IXPs. We demonstrate here our implementations of traffic engineering and Distributed Denial of Service mitigation, as well as how member networks cash in on the advanced SDN-features of ENDEAVOUR, typically not available in legacy networks.
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| 5. |
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| 6. |
- Marcos, P., et al.
(författare)
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Dynam-IX : A dynamic interconnection exchange
- 2018
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Ingår i: SIGCOMM 2018 - Proceedings of the 2018 Posters and Demos, Part of SIGCOMM 2018. - New York, NY, USA : Association for Computing Machinery, Inc. - 9781450359153 ; , s. 12-14
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Konferensbidrag (refereegranskat)
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