| 1. |
- O'Seaghdha, Conall M., et al.
(författare)
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Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations
- 2013
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Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 9:9, s. e1003796-
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Tidskriftsartikel (refereegranskat)abstract
- Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in <= 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.
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| 2. |
- Qin, Gang, et al.
(författare)
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An as-cast high-entropy alloy with remarkable mechanical properties strengthened by nanometer precipitates
- 2020
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Ingår i: Nanoscale. - : ROYAL SOC CHEMISTRY. - 2040-3364 .- 2040-3372. ; 12:6, s. 3965-3976
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Tidskriftsartikel (refereegranskat)abstract
- High-entropy alloys (HEAs) with good ductility and high strength are usually prepared by a combination of forging and heat-treatment processes. In comparison, the as-cast HEAs typically do not reach strengths similar to those of HEAs produced by the forging and heat-treatment processes. Here we report a novel equiatomic-ratio CoCrCuMnNi HEA prepared by vacuum arc melting. We observe that this HEA has excellent mechanical properties, i.e., a yield strength of 458 MPa, and an ultimate tensile strength of 742 MPa with an elongation of 40%. Many nanometer precipitates (5-50 nm in size) and domains (5-10 nm in size) are found in the inter-dendrite and dendrite zones of the produced HEA, which is the key factor for its excellent mechanical properties. The enthalpy of mixing between Cu and Mn, Cr, Co, or Ni is higher than those of mixing between any two of Cr, Co, Ni and Mn, which leads to the separation of Cu from the CoCrCuMnNi HEA. Furthermore, we reveal the nanoscale-precipitate-phase-forming mechanism in the proposed HEA.
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| 3. |
- Sharma, V., et al.
(författare)
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Improved mechanical properties of a Ti-48Al alloy processed by mechanical alloying and spark plasma sintering
- 2023
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Ingår i: Materials Today Communications. - : Elsevier BV. - 2352-4928. ; 35
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Tidskriftsartikel (refereegranskat)abstract
- Bulk Ti-48Al alloy samples were prepared by the high energy ball milling (HBM) of elemental powders, followed by spark plasma sintering (SPS) of the HBM processed powders. The microstructure, phase evolution and mechanical properties of the bulk alloy were studied. The resulting TiAl + Ti3Al two phase alloy possessed an equiaxed fine grain structure, unlike the usual lamellar structure produced by arc melting. The process parameters of HBM and SPS, e.g., milling speed, milling time and sintering temperature were used to tune the phase fraction, microstructure, and grain size. A very high nanohardness of up to ∼12 GPa was obtained, ∼2.4 times higher than the corresponding value of the as-cast counterpart. The combined influence of powder size reduction during HBM, high Ti3Al phase fraction and microstructural development during SPS resulted in higher hardness, wear resistance and yield pressure. Thus, a HBM+SPS processing approach is a promising processing route for the manufacture of high hardness bulk TiAl alloys.
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