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- Cecconello, Marco, et al.
(författare)
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First observations of confined fast ions in MAST Upgrade with an upgraded neutron camera
- 2023
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Ingår i: Plasma Physics and Controlled Fusion. - : Institute of Physics Publishing (IOPP). - 0741-3335 .- 1361-6587. ; 65:3
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Tidskriftsartikel (refereegranskat)abstract
- Spherical tokamaks are key to the successful design of operating scenarios of future fusion reactors in the areas of divertor physics, neutral beam current drive and fast ion physics. MAST Upgrade, which has successfully concluded its first experimental campaign, was specifically designed to address the role of the radial gradient of the fast ion distribution in driving the excitation of magneto-hydrodynamic (MHD) instabilities, such as toroidal Alfven eigenmodes, fish-bones and long-lived mode, thanks to its two tangential neutral beam injection systems, one on the equatorial plane and one that is vertically shifted 65 cm above the equatorial plane. To study the fast ion dynamics in the presence of such instabilities, as well as of sawteeth and neo-classical tearing modes, several fast ion diagnostics were upgraded and new ones added. Among them, the MAST prototype neutron camera (NC) has been upgraded to six, equatorial sight-lines. The first observations of the confined fast ion behavior with the upgraded NC in a wide range of plasma scenarios characterized by on-axis and/or off-axis heating and different MHD instabilities are presented here. The observations presented in this study confirm previous results on MAST but with a higher level of detail and highlight new physics observations unique to the MAST Upgrade. The results presented here confirm the improved performance of the NC Upgrade, which thus becomes one of the key elements, in combination with the rich set of fast ion diagnostics available on the MAST Upgrade, for a more constrained modeling of the fast ion dynamics in fusion reactor relevant scenarios.
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| 2. |
- Steinthorsdottir, V, et al.
(författare)
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Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 5976-
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Tidskriftsartikel (refereegranskat)abstract
- Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
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| 3. |
- Buckland, Paul C., et al.
(författare)
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Excavations on Roman pottery kiln sites in Cantley Parish, South Yorkshire, 1956–1975
- 2022
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Ingår i: Journal of Roman Pottery Studies Volume 19. - : Oxbow Books. - 9781789258264 - 9781789258257 ; , s. 44-146
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Bokkapitel (refereegranskat)abstract
- The South Yorkshire Roman pottery industry is concentrated largely in the parish of Cantley, immediately south-east ofDoncaster, the site of the fort and associated settlement of Danvm. Over seventy kilns, lying either side of the Lincolnto York via Castleford road, have been located, of which 55 have been excavated. This report deals with the remainingunpublished material, that from Cantley Kilns 30–32, 35–36 and 40–44. The earliest excavated kilns belong to themid-second century and production continued at least until the mid-fourth century. Material from Doncaster and othersites, however, suggests that earlier local late first and early second century production centres remain to be identified.Kiln types range from surface-built with removable furniture, to more substantial deeply excavated types with survivinginternal structures, including radial firebars over single and double pedestals, to more massive permanent floors overup to four pedestals. The products include mortaria, beakers, cooking pots/jars and bowls. White slip is employed onmortaria and red and white paint occurs on a few other vessels. Most of the material is in a hard gritty fabric producedin both light grey and red oxidised forms with varying degrees of burnishing. The mortaria have Mancetter/Hartshillaffinities which appear evident even after the demise of stamping by SARRIVS and others, and the cooking pots andbowls, reflect the general trend of Black-burnished ware production, although the latest forms do not occur. Threetypes, lid-seated jars, wide-mouthed/shouldered bowls and large bowls/pancheons of truncated conical form, belongto different, perhaps Continental traditions. Whilst most of the material appears to have been marketed locally, a fewvessels travelled further, particularly in the mid-second century, when Rossington Bridge, on the southern edge of theindustry, was involved in supply to the Antonine Wall.
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| 6. |
- White, Harvey D., et al.
(författare)
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In patients with stable coronary heart disease, low-density lipoprotein-cholesterol levels < 70 mg/dL and glycosylated hemoglobin A1c < 7% are associated with lower major cardiovascular events
- 2020
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Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 225, s. 97-107
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundIn patients with stable coronary heart disease, it is not known whether achievement of standard of care (SOC) targets in addition to evidence-based medicine (EBM) is associated with lower major adverse cardiovascular events (MACE): cardiovascular death, myocardial infarction, and stroke.MethodsEBM use was recommended in the STabilisation of Atherosclerotic plaque By Initiation of darapLadIb TherapY trial. SOC targets were blood pressure (BP) <140/90 mm Hg and low-density lipoprotein-cholesterol (LDL-C) <100 mg/dL and <70 mg/dL. In patients with diabetes, glycosylated hemoglobin A1c (HbA1c) < 7% and BP of <130/80 mm Hg were recommended. Feedback to investigators about rates of EBM and SOC was provided regularly.ResultsIn 13,623 patients, 1-year landmark analysis assessed the association between EBM, SOC targets, and MACE during follow-up of 2.7 years (median) after adjustment in a Cox proportional hazards model.At 1 year, aspirin was prescribed in 92.5% of patients, statins in 97.2%, β-blockers in 79.0%, and angiotensin-converting enzyme inhibitors/angiotensin-II receptor blockers in 76.9%. MACE was lower with LDL-C < 100 mg/dL (70-99 mg/dL) compared with LDL-C ≥ 100 mg/dL (hazard ratio [HR] 0.694, 95% CI 0.594-0.811) and lower with LDL-C < 70 mg/dL compared with LDL-C < 100 mg/dL (70-99 mg/dL) (HR 0.834, 95% CI 0.708-0.983). MACE was lower with HbA1c < 7% compared with HbA1c ≥ 7% (HR 0.705, 95% CI 0.573-0.866). There was no effect of BP targets on MACE.ConclusionsMACE was lower with LDL-C < 100 mg/dL (70-99 mg/dL) and even lower with LDL-C < 70 mg/dL. MACE in patients with diabetes was lower with HbA1c < 7%. Achievement of targets is associated with improved patient outcomes.
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