| 1. |
- Hailemariam, F. M., et al.
(författare)
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Investigating the influence of minor hydraulic structures on modeling flood events in lowland areas
- 2014
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Ingår i: Hydrological Processes. - : Wiley. - 1099-1085 .- 0885-6087. ; 28:4, s. 1742-1755
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Tidskriftsartikel (refereegranskat)abstract
- Flood inundation models have been recognized to be a valuable tool to reproduce flow dynamics in a given area and support decision-making processes on flood management measures. In many cases, in the simulation of flood events, only the main river channel and the associated structures are represented within the model. However, during flood events involving lowland areas, the minor drainage network - and the associated hydraulic structures - may have an important role in conveying flow and determining which areas will be flooded. The objective of this study is to investigate whether - and to what extent - small hydraulic structures in drainage networks have an influence in flooding on lowland areas. The case study for this research is the 1990 flood event which occurred in the lowland plain of the Reno River, in Northern Italy. The study area is mainly used for agricultural purposes and has a drainage system with several small bridges and culverts. The influence of the minor hydraulic structures on flood dynamics was analyzed through a combined use of one-dimensional (1D) and two-dimensional (2D) hydraulic models. First, a number of detailed and simplified approaches to represent hydraulic structures in the computational grids were analyzed by means of the HECRAS 1D model. Second, these approaches were implemented and tested in several 2D simulations of the flood event. The simulated inundation extents and flood levels were then compared with the observed data and with each other. The analysis of results showed that simplified schematizations were sufficient to obtain good model predictions of peak inundation extent and flood levels, at least for the present case study. Moreover, the influence of the structures on the peak flood inundation extent and flood levels was found to be limited, whereas it showed to be more significant during the drainage phase of the flood.
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| 2. |
- Kullander, Klas, et al.
(författare)
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Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo
- 2001
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Ingår i: Neuron. - 0896-6273 .- 1097-4199. ; 29:1, s. 73-84
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Tidskriftsartikel (refereegranskat)abstract
- The EphA4 receptor tyrosine kinase regulates the formation of the corticospinal tract (CST), a pathway controlling voluntary movements, and of the anterior commissure (AC), connecting the neocortical temporal lobes. To study EphA4 kinase signaling in these processes, we generated mice expressing mutant EphA4 receptors either lacking kinase activity or with severely downregulated kinase activity. We demonstrate that EphA4 is required for CST formation as a receptor for which it requires an active kinase domain. In contrast, the formation of the AC is rescued by kinase-dead EphA4, suggesting that in this structure EphA4 acts as a ligand for which its kinase activity is not required. Unexpectedly, the cytoplasmic sterile-alpha motif (SAM) domain is not required for EphA4 functions. Our findings establish both kinase-dependent and kinase-independent functions of EphA4 in the formation of major axon tracts.
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| 3. |
- Larsson, Maria E H, 1969, et al.
(författare)
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Prevention of sickness absence through early identification and rehabilitation of at-risk patients with musculoskeletal pain (PREVSAM): a randomised controlled trial protocol
- 2020
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Ingår i: BMC Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundMusculoskeletal pain is globally a leading cause of physical disability. Many musculoskeletal-related pain conditions, such as low back pain, often resolve spontaneously. In some individuals, pain may recur or persist, leading to ong-term physical disability, reduced work capacity, and sickness absence. Early identification of individuals in which this may occur, is essential for preventing or reducing the risk of developing persistent musculoskeletal pain and long-term sickness absence. The aim of the trial described in this protocol is to evaluate effects of an early intervention, the PREVSAM model, on the prevention of sickness absence and development of persistent pain in at-risk patients with musculoskeletal pain.MethodsEligible participants are adults who seek health care for musculoskeletal pain and who are at risk of developing persistent pain, physical disability, and sickness absence. Participants may be recruited from primary care rehabilitation centres or primary care healthcare centres in Region Vastra Gotaland. Participants will be randomised to treatment according to the PREVSAM model (intervention group) or treatment as usual (control group). The PREVSAM model comprises an interdisciplinary, person-centred rehabilitation programme, including coordinated measures within primary health care, and may include collaboration with participants' employers. The primary outcome sickness absence is operationalised as the number and proportion of individuals who remain in full- or part-time work, the number of gross and net days of sickness absence during the intervention and follow-up period, and time to first sickness absence spell. Secondary outcomes are patient-reported short-term sickness absence, work ability, pain, self-efficacy, health-related quality of life, risk for sickness absence, anxiety and depression symptoms and physical disability at 1 and 3months after inclusion (short-term follow-up), and at 6 and 12months (long-term follow-up). A cost-effectiveness analysis is planned and drug consumption will be investigated.DiscussionThe study is expected to provide new knowledge on the effectiveness of a comprehensive rehabilitation model that incorporates early identification of patients with musculoskeletal pain at risk for development of sickness absence and persistent pain. The study findings may contribute to more effective rehabilitation processes of this large patient population, and potentially reduce sickness absence and costs.Trial registrationClinicalTrials.gov Protocol ID: NCT03913325, Registered April 12, 2019.Version 2, 10 July 2020.Version 2 changes: Clarifications regarding trial aim and inclusion process.
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| 4. |
- Mazzoleni, Maurizio, et al.
(författare)
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Effects of levee cover strength on flood mapping in the case of levee breach due to overtopping
- 2017
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Ingår i: Hydrological Sciences Journal. - : Taylor and Francis Ltd.. - 0262-6667 .- 2150-3435. ; 62:6, s. 892-910
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Tidskriftsartikel (refereegranskat)abstract
- The reliability of a levee system is a crucial factor in flood risk management. In this study we present a probabilistic methodology to assess the effects of levee cover strength on levee failure probability, triggering time, flood propagation and consequent impacts on population and assets. A method for determining fragility curves is used in combination with the results of a one-dimensional hydrodynamic model to estimate the conditional probability of levee failure in each river section. Then, a levee breach model is applied to calculate the possible flood hydrographs, and for each breach scenario a two-dimensional hydrodynamic model is used to estimate flood hazard (flood extent and timing, maximum water depths) and flood impacts (economic damage and affected population) in the areas at risk along the river reach. We show an application for levee overtopping and different flood scenarios for a 98 km reach of the lower Po River in Italy. The results show how different design solutions for the levee cover can influence the probability of levee failure and the consequent flood scenarios. In particular, good grass cover strength can significantly delay levee failure and reduce maximum flood depths in the flood-prone areas, thus helping the implementation of flood risk management actions.
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