SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Drayson Mark T.) "

Sökning: WFRF:(Drayson Mark T.)

  • Resultat 1-3 av 3
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  • Turesson, Ingemar, et al. (författare)
  • Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden.
  • 2014
  • Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 123:3, s. 338-345
  • Tidskriftsartikel (refereegranskat)abstract
    • In 728 Swedish cases of monoclonal gammopathy of undetermined significance (MGUS), followed up to 30 years (median 10 years), we estimated the cumulative risk of hematologic disorders originating from lymphoid and myeloid lineages. Using Cox regression models, we examined associations of demographic and laboratory factors with progression and determined the discriminatory power of three prediction models for progression. Eighty-four MGUS cases developed a lymphoid disorder, representing a cumulative risk of 15.4%. Multiple myeloma (MM) occurred in 53 patients and the 30-year cumulative risk was 10.6%; an approximate 0.5% annual risk. Three factors were significantly associated with progression: abnormal FLC-ratio (<0.26 or >1.65), M-protein concentration ≥1.5g/dL ( > or = 1,5 g/dL), and reduction of 1 or 2 non-involved immunoglobulin isotype levels (immunoparesis). A prediction model with separate effects for these three factors and the M-protein isotype had higher discriminatory power than other models, though the differences were not statistically significant. The 30-year cumulative risk for myeloid malignancies was <2%. Our study confirms that abnormal FLC-ratio and M-protein concentration >1.5g/dL, factors previously considered by Mayo Clinic researchers, are predictors for MM progression and suggests that separate consideration of immunoparesis and the Mayo Clinic risk factors could improve identification of MGUS patients at high risk for progression.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-3 av 3

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy