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- De Pieri, Andrea, et al.
(author)
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Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs
- 2018
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In: Journal of materials science. Materials in medicine. - : Springer. - 0957-4530 .- 1573-4838. ; 29:8
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Research review (peer-reviewed)abstract
- The 4(th) Translational Research Symposium (TRS) was organised at the annual meeting of the European Society for Biomaterials (ESB) 2017, Athens, Greece, with a focus on 'Academia-Industry Clusters of Research for Innovation Catalysis'. Collaborations between research institutes and industry can be sustained in several ways such as: European Union (EU) funded consortiums; syndicates of academic institutes, clinicians and industries; funding from national governments; and private collaborations between universities and companies. Invited speakers from industry and research institutions presented examples of these collaborations in the translation of research ideas or concepts into marketable products. The aim of the present article is to summarize the key messages conveyed during these lectures. In particular, emphasis is put on the challenges to appropriately identify and select unmet clinical needs and their translation by ultimately implementing innovative and efficient solutions achieved through joint academic and industrial efforts.
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| 2. |
- Faridi, Muhammad Asim, et al.
(author)
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Glass Capillary based cavity resonator for particle trapping study and bacteria up-concentration
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In: Biomedical microdevices (Print). - 1387-2176 .- 1572-8781.
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Journal article (peer-reviewed)abstract
- We have performed particle aggregation characterization on the basis of their material and suspendingmedium in a capillary-based cavity resonator used for acoustophoresis. We have investigated the experimentalaggregation time of 5μm polystyrene and silica particles, size of aggregate, number of trapped particles and upconcentrationfactor in water, 0.01M phosphate buffered saline (PBS) and 0.005M PBS at 1.97MHz and withactuation voltages between 4, 8 and 12Vpp. We have found that there is little difference between using water andPBS as suspension medium, approximately 5-10% longer trapping times with PBS compared with water.However we get approx. 5.5 times faster trapping time for silica than for polystyrene. It is also observed andcalculated that silica particle aggregates have 3.4 times larger area than the polystyrene aggregates using the samestarting particle concentrations, revealing similar amount of difference in trapped number of particles. The upconcentrationfactor for silica is also about 3.2 times higher than that of polystyrene due to larger aggregate areaof silica particles. Based on theoretical predictions and experimental characterization of the particle aggregationpattern, we note that the particle-particle interaction force contribution to the total acoustic radiation force is morepronounced for silica than for polystyrene. Finally as a proof of principle for biomedical sample preparationapplication we demonstrate the capillary-based silica particles mediated bacteria acoustophoretic upconcentration.This setup could potentially be utilized not only for sample preparation application but also forbead based affinity immunoassays.
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| 3. |
- Houben, Annemie, et al.
(author)
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Indirect Solid Freeform Fabrication of an Initiator-Free Photocrosslinkable Hydrogel Precursor for the Creation of Porous Scaffolds
- 2016
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In: Macromolecular Bioscience. - : Wiley. - 1616-5187 .- 1616-5195. ; 16:12, s. 1883-1894
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Journal article (peer-reviewed)abstract
- In the present work, a photopolymerized urethane-based poly(ethylene glycol) hydrogel is applied as a porous scaffold material using indirect solid freeform fabrication (SFF). This approach combines the benefits of SFF with a large freedom in material selection and applicable concentration ranges. A sacrificial 3D poly(epsilon-caprolactone) structure is generated using fused deposition modeling and used as template to produce hydrogel scaffolds. By changing the template plotting parameters, the scaffold channel sizes vary from 280 to 360 m, and the strut diameters from 340 to 400 m. This enables the production of scaffolds with tunable mechanical properties, characterized by an average hardness ranging from 9 to 43 N and from 1 to 6 N for dry and hydrated scaffolds, respectively. Experiments using mouse calvaria preosteoblasts indicate that a gelatin methacrylamide coating of the scaffolds results in an increased cell adhesion and proliferation with improved cell morphology.
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