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1.	Duits, Flora H, et al. (author) Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study. 2016 In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279 .- 1552-5260. ; 12:2, s. 154-163 Journal article (peer-reviewed)abstract Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations.
2.	Duits, Flora H., et al. (author) The cerebrospinal fluid "Alzheimer profile": Easily said, but what does it mean? 2014 In: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 10:6, s. 713-723 Journal article (peer-reviewed)abstract Background: We aimed to identify the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-beta(1-42) (A beta(42)), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimers disease (AD). Methods: We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442). Results: Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/A beta(42) ratio and 0.08 for the p-tau/A beta(42) ratio. Ratios performed similar to formulas (sensitivity, 91%-93%; specificity, 81%-84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/A beta(42) ratio. Conclusions: A tau/A beta(42) ratio of greater than0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers.
3.	Engelborghs, Sebastiaan, et al. (author) Consensus guidelines for lumbar puncture in patients with neurological diseases 2017 In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. - : Wiley. - 2352-8729. ; 8, s. 111-126 Journal article (peer-reviewed)abstract Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.
4.	Kvartsberg, Hlin, 1987, et al. (author) Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease. 2015 In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279 .- 1552-5260. ; 11:10, s. 1180-1190 Journal article (peer-reviewed)abstract Synaptic dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and directly related to cognitive impairment. Consequently, synaptic biomarkers may be valuable tools for both early diagnosis and disease stage. Neurogranin (Ng) is a postsynaptic protein involved in memory consolidation.

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Scheltens, Philip (4); Teunissen, Charlotte ... (4); Blennow, Kaj, 1958 (3); Minthon, Lennart (3); Zetterberg, Henrik, ... (3); Wallin, Anders, 1950 (3); show more...; Ingelsson, Martin (3); van der Flier, Wiesj ... (3); Tsolaki, Magda (2); Hansson, Oskar (2); Stomrud, Erik (2); Lleó, Alberto (2); Andreasen, Niels (2); Engelborghs, Sebasti ... (2); Parnetti, Lucilla (2); Visser, Pieter Jelle (2); de Mendonça, Alexand ... (2); Frölich, Lutz (2); Tumani, Hayrettin (1); Kuhle, Jens (1); Aarsland, Dag (1); Olde Rikkert, Marcel (1); Brinkmalm, Gunnar (1); Lannfelt, Lars (1); Marcusson, Jan (1); Portelius, Erik, 197 ... (1); Winblad, Bengt (1); Blennow, Kaj (1); Iacobaeus, Ellen (1); Molinuevo, José Luis (1); Martínez-Lage, Pablo (1); Izagirre, Andrea (1); Balasa, Mircea (1); Kvartsberg, Hlin, 19 ... (1); Andreasson, Ulf, 196 ... (1); Gnanapavan, Sharmile ... (1); Zetterberg, Henrik (1); Andersson, Kerstin (1); Mattsson, Niklas, 19 ... (1); Molinuevo, José L (1); Galimberti, Daniela (1); Rosa-Neto, Pedro (1); Hampel, Harald (1); Hemmer, Bernhard (1); Nagels, Guy (1); Jonsson, Michael (1); Öhrfelt, Annika, 197 ... (1); de Leon, Mony J (1); van der Flier, Wiesj ... (1); Hausner, Lucrezia (1); show less...

University: University of Gothenburg (4); Lund University (4); Karolinska Institutet (3); Uppsala University (2); Linköping University (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (4)

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