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Sökning: WFRF:(Dumur E.)

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1.
  • Krupko, Yu., et al. (författare)
  • Kerr nonlinearity in a superconducting Josephson metamaterial
  • 2018
  • Ingår i: Physical Review B. - : American Physical Society. - 2469-9950 .- 2469-9969. ; 98:9
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a detailed experimental and theoretical analysis of the dispersion and nonlinear Kerr frequency shifts of plasma modes in a one-dimensional Josephson junction chain containing 500 superconducting quantum interfence devices in the regime of weak nonlinearity. The measured low-power dispersion curve agrees perfectly with the theoretical model if we take into account the Kerr renormalization of the bare frequencies and the long-range nature of the island charge screening by a remote ground plane. We measured the self- and cross-Kerr shifts for the frequencies of the eight lowest modes in the chain. We compare the measured Kerr coefficients with theory and find good agreement.
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2.
  • Malapelle, Umberto, et al. (författare)
  • Reference standards for gene fusion molecular assays on cytological samples : an international validation study
  • 2023
  • Ingår i: Journal of Clinical Pathology. - : BMJ. - 0021-9746 .- 1472-4146. ; 76:1, s. 47-52
  • Tidskriftsartikel (refereegranskat)abstract
    • Aims Gene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary validation that may make use of cell line slides mimicking cytological samples. In this international multi-institutional study, gene fusion reference standards were developed and validated. Methods Cell lines harbouring EML4(13)–ALK(20) and SLC34A2(4)–ROS1(32) gene fusions were adopted to prepare reference standards. Eight laboratories (five adopting amplicon-based and three hybridisation-based platforms) received, at different dilution points two sets of slides (slide A 50.0%, slide B 25.0%, slide C 12.5% and slide D wild type) stained by Papanicolaou (Pap) and May Grunwald Giemsa (MGG). Analysis was carried out on a total of 64 slides. Results Four (50.0%) out of eight laboratories reported results on all slides and dilution points. While 12 (37.5%) out of 32 MGG slides were inadequate, 27 (84.4%) out of 32 Pap slides produced libraries adequate for variant calling. The laboratories using hybridisation-based platforms showed the highest rate of inadequate results (13/24 slides, 54.2%). Conversely, only 10.0% (4/40 slides) of inadequate results were reported by laboratories adopting amplicon-based platforms. Conclusions Reference standards in cytological format yield better results when Pap staining and processed by amplicon-based assays. Further investigation is required to optimise these standards for MGG stained cells and for hybridisation-based approaches.
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