| 1. |
- Durán-Acevedo, Cristhian Manuel, et al.
(författare)
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Exhaled breath analysis for gastric cancer diagnosis in Colombian patients.
- 2018
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 9:48, s. 28805-28817
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Tidskriftsartikel (refereegranskat)abstract
- We present here the first study that directly correlates gastric cancer (GC) with specific biomarkers in the exhaled breath composition on a South American population, which registers one of the highest global incidence rates of gastric affections. Moreover, we demonstrate a novel solid state sensor that predicts correct GC diagnosis with 97% accuracy. Alveolar breath samples of 30 volunteers (patients diagnosed with gastric cancer and a controls group formed of patients diagnosed with other gastric diseases) were collected and analyzed by gas-chromatography/mass-spectrometry (GC-MS) and with an innovative chemical gas sensor based on gold nanoparticles (AuNP) functionalized with octadecylamine ligands. Our GC-MS analyses identified 6 volatile organic compounds that showed statistically significant differences between the cancer patients and the controls group. These compounds were different from those identified in previous studied performed on other populations with high incidence rates of this malady, such as China (representative for Eastern Asia region) and Latvia (representative for Baltic States), attributable to lifestyle, alimentation and genetics differences. A classification model based on principal component analysis of our sensor data responses to the breath samples yielded 97% accuracy, 100% sensitivity and 93% specificity. Our results suggest a new and non-intrusive methodology for early diagnosis of gastric cancer that may be deployed in regions lacking well-developed health care systems as a prediagnosis test for selecting the patients that should undergo deeper investigations (e.g., endoscopy and biopsy).
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| 2. |
- de Jesus Beleno-Saenz, Kelvin, et al.
(författare)
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Non-Invasive Method to Detect Infection with Mycobacterium tuberculosis Complex in Wild Boar by Measurement of Volatile Organic Compounds Obtained from Feces with an Electronic Nose System
- 2021
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Ingår i: Sensors. - : MDPI. - 1424-8220. ; 21:2
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Tidskriftsartikel (refereegranskat)abstract
- More effective methods to detect bovine tuberculosis, caused by Mycobacterium bovis, in wildlife, is of paramount importance for preventing disease spread to other wild animals, livestock, and human beings. In this study, we analyzed the volatile organic compounds emitted by fecal samples collected from free-ranging wild boar captured in Donana National Park, Spain, with an electronic nose system based on organically-functionalized gold nanoparticles. The animals were separated by the age group for performing the analysis. Adult (>24 months) and sub-adult (12-24 months) animals were anesthetized before sample collection, whereas the juvenile (<12 months) animals were manually restrained while collecting the sample. Good accuracy was obtained for the adult and sub-adult classification models: 100% during the training phase and 88.9% during the testing phase for the adult animals, and 100% during both the training and testing phase for the sub-adult animals, respectively. The results obtained could be important for the further development of a non-invasive and less expensive detection method of bovine tuberculosis in wildlife populations.
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| 3. |
- Welearegay, Tesfalem, et al.
(författare)
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Exhaled air analysis as a potential fast method for early diagnosis of dengue disease
- 2020
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Ingår i: Sensors and actuators. B, Chemical. - Netherlands : Elsevier BV. - 0925-4005 .- 1873-3077. ; 310
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Tidskriftsartikel (refereegranskat)abstract
- Dengue is a neglected tropical disease caused by arbovirus. Every year 390 million persons are infected with dengue, of which 96 million manifest clinically around the world, mainly in the Latin America, South-East Asia and Western Pacific. The disease manifests itself as a flu-like infection that generally is difficult to recognise from a normal flu or other viral infections. The mortality rate is around 20 % for the severe form of dengue, which readily could be decreased to below 1% with early, reliable diagnostic tools. Today there exist however no diagnostic tests for the early and rapid diagnosis of this disease. In this study, we report for the first time the possibility of identification of possible biomarkers associated with dengue disease in the exhaled air, and of the development of a breath test for fast, non-invasive and easy diagnosis of this disease. Further, we demonstrate a new deployable sensor technology based on a chemoresistive metal-ligand nanoassembly tailored for the identified possible biomarkers of dengue disease, which achieved 100 % accuracy for dengue diagnosis on our study group and can be used in both specialist and non-specialist settings. Nevertheless, as the present study was performed on a limited number of patients because of the difficulty to recruit a high number of patients because dengue is a neglected disease, future validation tests on a higher cohort are necessary for corroborating the results obtained in the present study.
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