| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
- Leisawitz, David, et al.
(författare)
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The origins space telescope
- 2019
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 11115
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Konferensbidrag (refereegranskat)abstract
- The Origins Space Telescope will trace the history of our origins from the time dust and heavy elements permanently altered the cosmic landscape to present-day life. How did galaxies evolve from the earliest galactic systems to those found in the universe today? How do habitable planets form? How common are life-bearing worlds? To answer these alluring questions, Origins will operate at mid-and far-infrared wavelengths and offer powerful spectroscopic instruments and sensitivity three orders of magnitude better than that of Herschel, the largest telescope flown in space to date. After a 3 1/2 year study, the Origins Science and Technology Definition Team will recommend to the Decadal Survey a concept for Origins with a 5.9-m diameter telescope cryocooled to 4.5 K and equipped with three scientific instruments. A mid-infrared instrument (MISC-T) will measure the spectra of transiting exoplanets in the 2.8-20 μm wavelength range and offer unprecedented sensitivity, enabling definitive biosignature detections. The Far-IR Imager Polarimeter (FIP) will be able to survey thousands of square degrees with broadband imaging at 50 and 250 μm. The Origins Survey Spectrometer (OSS) will cover wavelengths from 25-588 μm, make wide-area and deep spectroscopic surveys with spectral resolving power R ∼ 300, and pointed observations at R ∼ 40,000 and 300,000 with selectable instrument modes. Origins was designed to minimize complexity. The telescope has a Spitzer-like architecture and requires very few deployments after launch. The cryo-thermal system design leverages JWST technology and experience. A combination of current-state-of-the-art cryocoolers and next-generation detector technology will enable Origins' natural backgroundlimited sensitivity.
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| 5. |
- Leisawitz, David, et al.
(författare)
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Origins Space Telescope: Baseline mission concept
- 2021
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Ingår i: Journal of Astronomical Telescopes, Instruments, and Systems. - 2329-4221 .- 2329-4124. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- The Origins Space Telescope will trace the history of our origins from the time dust and heavy elements permanently altered the cosmic landscape to present-day life. How did galaxies evolve from the earliest galactic systems to those found in the Universe today? How do habitable planets form? How common are life-bearing worlds? To answer these alluring questions, Origins will operate at mid-and far-infrared (IR) wavelengths and offer powerful spectroscopic instruments and sensitivity three orders of magnitude better than that of the Herschel Space Observatory, the largest telescope flown in space to date. We describe the baseline concept for Origins recommended to the 2020 US Decadal Survey in Astronomy and Astrophysics. The baseline design includes a 5.9-m diameter telescope cryocooled to 4.5 K and equipped with three scientific instruments. A mid-infrared instrument (Mid-Infrared Spectrometer and Camera Transit spectrometer) will measure the spectra of transiting exoplanets in the 2.8 to 20 μm wavelength range and offer unprecedented spectrophotometric precision, enabling definitive exoplanet biosignature detections. The far-IR imager polarimeter will be able to survey thousands of square degrees with broadband imaging at 50 and 250 μm. The Origins Survey Spectrometer will cover wavelengths from 25 to 588 μm, making wide-area and deep spectroscopic surveys with spectral resolving power R ∼ 300, and pointed observations at R ∼ 40,000 and 300,000 with selectable instrument modes. Origins was designed to minimize complexity. The architecture is similar to that of the Spitzer Space Telescope and requires very few deployments after launch, while the cryothermal system design leverages James Webb Space Telescope technology and experience. A combination of current-state-of-the-art cryocoolers and next-generation detector technology will enable Origins' natural background-limited sensitivity.
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| 6. |
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| 7. |
- Earle, K. A., et al.
(författare)
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Quantitative Imaging of Gut Microbiota Spatial Organization
- 2015
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Ingår i: Cell Host and Microbe. - : Elsevier BV. - 1931-3128. ; 18:4, s. 478-488
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Tidskriftsartikel (refereegranskat)abstract
- Summary Genomic technologies have significantly advanced our understanding of the composition and diversity of host-associated microbial populations. However, their spatial organization and functional interactions relative to the host have been more challenging to study. Here we present a pipeline for the assessment of intestinal microbiota localization within immunofluorescence images of fixed gut cross-sections that includes a flexible software package, BacSpace, for high-throughput quantification of microbial organization. Applying this pipeline to gnotobiotic and human microbiota-colonized mice, we demonstrate that elimination of microbiota-accessible carbohydrates (MACs) from the diet results in thinner mucus in the distal colon, increased proximity of microbes to the epithelium, and heightened expression of the inflammatory marker REG3β. Measurements of microbe-microbe proximity reveal that a MAC-deficient diet alters monophyletic spatial clustering. Furthermore, we quantify the invasion of Helicobacter pylori into the glands of the mouse stomach relative to host mitotic progenitor cells, illustrating the generalizability of this approach. © 2015 Elsevier Inc.
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| 8. |
- Padwal, R., et al.
(författare)
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The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data
- 2014
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Ingår i: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 38:8, s. 1110-1114
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Tidskriftsartikel (refereegranskat)abstract
- Background:In heart failure (HF), obesity, defined as body mass index (BMI) >/=30 kg m-2, is paradoxically associated with higher survival rates compared with normal-weight patients (the 'obesity paradox'). We sought to determine if the obesity paradox differed by HF subtype (reduced ejection fraction (HF-REF) versus preserved ejection fraction (HF-PEF)).Patients and Methods:A sub-analysis of the MAGGIC meta-analysis of patient-level data from 14 HF studies was performed. Subjects were divided into five BMI groups: <22.5, 22.5-24.9 (referent), 25-29.9, 30-34.9 and >/=35 kg m-2. Cox proportional hazards models adjusted for age, sex, aetiology (ischaemic or non-ischaemic), hypertension, diabetes and baseline blood pressure, stratified by study, were used to examine the independent association between BMI and 3-year total mortality. Analyses were conducted for the overall group and within HF-REF and HF-PEF groups.Results:BMI data were available for 23 967 subjects (mean age, 66.8 years; 32% women; 46% NYHA Class II; 50% Class III) and 5609 (23%) died by 3 years. Obese patients were younger, more likely to receive cardiovascular (CV) drug treatment, and had higher comorbidity burdens. Compared with BMI levels between 22.5 and 24.9 kg m-2, the adjusted relative hazards for 3-year mortality in subjects with HF-REF were: hazard ratios (HR)=1.31 (95% confidence interval=1.15-1.50) for BMI <22.5, 0.85 (0.76-0.96) for BMI 25.0-29.9, 0.64 (0.55-0.74) for BMI 30.0-34.9 and 0.95 (0.78-1.15) for BMI >/=35. Corresponding adjusted HRs for those with HF-PEF were: 1.12 (95% confidence interval=0.80-1.57) for BMI <22.5, 0.74 (0.56-0.97) for BMI 25.0-29.9, 0.64 (0.46-0.88) for BMI 30.0-34.9 and 0.71 (0.49-1.05) for BMI >/=35.Conclusions:In patients with chronic HF, the obesity paradox was present in both those with reduced and preserved ventricular systolic function. Mortality in both HF subtypes was U-shaped, with a nadir at 30.0-34.9 kg m-2.International Journal of Obesity advance online publication, 26 November 2013; doi:10.1038/ijo.2013.203.
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| 9. |
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| 10. |
- Earle, Timothy K., et al.
(författare)
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The Political Economy and Metal Trade in Bronze Age Europe: Understanding Regional Variability in Terms of Comparative Advantages and Articulations
- 2015
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Ingår i: European Journal of Archaeology. - 1461-9571 .- 1741-2722. ; 18:4, s. 633-657
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Tidskriftsartikel (refereegranskat)abstract
- In the second millennium cal BC, a new metal conquered Europe: the alloy of copper and tin that improved the quality of tools and weapons. This development, we argue, initiated a framework for a new political economy. We explore how a political economy approach may help understand the European Bronze Age by focussing on regional comparative advantages in long-distance trade and resulting bottlenecks in commodity flows. Links existed in commodity chains, where obligated labour and ownership of resources helped mobilize surpluses, thus creating potential for social segments to control the production and flows of critical goods. The political economy of Bronze Age Europe would thus represent a transformation in how would-be leaders mobilized resources to support their political ends. The long-distance trade in metals and other commodities created a shift from local group ownership towards increasingly individual strategies to obtain wealth from macro-regional trade. We construct our argument to make sense of available data, but recognize that our model's primary purpose is to structure future research to test the model. Au cours du 2e millénaire av. J.-C. un nouveau métal conquérait l'Europe: l'alliage du cuivre et de l’étain, qui améliorait la qualité des outils et des armes. Nous soutenons ici que ce développement instaurait un cadre pour une nouvelle économie politique et nous examinons comment une approche fondée sur l’économie politique peut nous permettre de mieux comprendre l’Âge du Bronze européen, en mettant l'accent sur les avantages comparatifs régionaux lors des échanges à longue distance et sur les goulets d’étranglement des flux de marchandises qui en résultent. Il existait des liens dans les filières des produits de base, où le travail forcé et la possession des ressources aidaient à réaliser des excédents, permettant ainsi à des segments de la société de contrôler la production et les flux de produits essentiels. L’économie politique de l'Europe pendant l’Âge du Bronze décrirait donc un changement dans la manière avec laquelle des leaders potentiels mobilisaient des ressources pour soutenir leurs fins politiques. Les échanges à longue distance de métaux et autres marchandises ont déclenché un changement allant de la propriété collective locale vers des stratégies de plus en plus individuelles afin de produire de la richesse à partir du commerce macro-régional. Avec nos arguments nous cherchons à interpréter les données disponibles, mais nous admettons que le principal objectif de notre modèle est de structurer la recherche future afin de pouvoir le mettre à l’épreuve. Translation by Isabelle Gerges Im zweiten Jahrtausend v. Chr. trat ein neues Metall seinen Siegeszug durch Europa an: die Legierung von Kupfer und Zinn, die die Qualität von Werkzeugen und Waffen verbesserte. Diese Entwicklung, so vermuten wir, stieß die Entwicklung eines Netzwerkes für eine neue politische Ökonomie an. Wir untersuchen, wie der Ansatz der politischen Ökonomie dabei helfen kann, unter besonderer Berücksichtigung regionaler vergleichender Nutzeffekte beim Fernhandel und daraus resultierender Engpässe bei Warenströmen die europäische Bronzezeit zu verstehen. Es existierten Verbindungen bei den Güterketten, bei denen Arbeitsverpflichtungen und Eigentum an den Ressourcen dabei halfen, Überschuss zu erwirtschaften – und dadurch ein Potential für soziale Segmentierung schufen, das die Kontrolle der Produktion und Verteilung von wesentlichen Gütern gewährleistete. Die politische Ökonomie der europäischen Bronzezeit spiegelt demnach einen Übergang wider, bei dem die angehenden Oberhäupter Ressourcen mobilisierten, um ihre politischen Ziele zu unterstützen. Der Fernhandel von Metallen und anderen Waren ermöglichte einen Sprung vom lokalen Gruppenbesitz hin zu vermehrt individuellen Strategien, um aus dem makroregionalen Handel Reichtum zu erzielen. Wir entwickeln unsere Beweisführung, um bereits vorhandene Daten deuten zu können, sind uns jedoch bewusst, dass das vorrangige Ziel unseres Modells die Struktur zukünftiger Forschung ist, um seine Gültigkeit zu testen.Translation by Heiner Schwarzberg
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