| 1. |
- Einsfeld, Katja, et al.
(författare)
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Knowledge Generation Through Human-Centered Information Visualization
- 2009
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Ingår i: Information Visualization. - : Palgrave Macmillan Ltd. - 1473-8716 .- 1473-8724. ; 8:3, s. 180-196
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Tidskriftsartikel (refereegranskat)abstract
- One important intention of human-centered information visualization is to represent huge amounts of abstract data in a visual representation that allows even users from foreign application domains to interact with the visualization, to understand the underlying data, and finally, to gain new, application-related knowledge. The visualization will help experts as well as non-experts to link previously or isolated knowledge-items in their mental map with new insights.Our approach explicitly supports the process of linking knowledge-items with three concepts. At first, the representation of data items in an ontology categorizes and relates them. Secondly, the use of various visualization techniques visually correlates isolated items by graph-structures, layout, attachment, integration, or hyperlink techniques. Thirdly, the intensive use of visual metaphors relates a known source domain to a less known target domain. In order to realize a scenario of these concepts, we developed a visual interface for non-experts to maintain complex wastewater treatment plants. This domain-specific application is used to give our concepts a meaningful background.
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| 2. |
- Nordengrahn, Ann, et al.
(författare)
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Evaluation of a novel proximity ligation assay for the sensitive and rapid detection of foot-and-mouth disease virus
- 2008
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Ingår i: Veterinary Microbiology. - : Elsevier BV. - 0378-1135 .- 1873-2542. ; 127:3-4, s. 227-236
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Tidskriftsartikel (refereegranskat)abstract
- A novel proximity ligation assay (PLA) using a pan-serotype reactive monoclonal antibody was developed and evaluated for the detection of foot-and-mouth disease virus (FMDV) in clinical samples collected from field cases of disease. The FMDV-specific PLA was found to be 100 times more sensitive for virus detection than the commonly used antigen capture-ELISA (AgELISA). As few as five TCID50 were detected in individual assays, which was comparable with the analytical sensitivity of real-time RT-PCR. Although this assay was capable of detecting diverse isolates from all seven FMDV serotypes, the diagnostic sensitivity of the PLA assay was lower than real-time RT-PCR mainly due to a failure to detect some SAT 1, SAT 2 and SAT 3 FMDV strains. In conclusion, this new PLA format has high analytical sensitivity for the detection of FMDV in clinical samples and may prove valuable as a rapid and simple tool for use in FMD diagnosis.
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