| 1. |
- Dunham, I, et al.
(författare)
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The DNA sequence of human chromosome 22
- 1999
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Klonoff, D. C., et al.
(författare)
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A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings
- 2022
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Ingår i: Journal of Diabetes Science and Technology. - : SAGE Publications. - 1932-2968.
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Tidskriftsartikel (refereegranskat)abstract
- Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful for assisting with basic clinical interpretation of CGM data. Methods: We assembled a data set of 14-day CGM tracings from 225 insulin-treated adults with diabetes. Using a balanced incomplete block design, 330 clinicians who were highly experienced with CGM analysis and interpretation ranked the CGM tracings from best to worst quality of glycemia. We used principal component analysis and multiple regressions to develop a model to predict the clinician ranking based on seven standard metrics in an Ambulatory Glucose Profile: very low–glucose and low-glucose hypoglycemia; very high–glucose and high-glucose hyperglycemia; time in range; mean glucose; and coefficient of variation. Results: The analysis showed that clinician rankings depend on two components, one related to hypoglycemia that gives more weight to very low-glucose than to low-glucose and the other related to hyperglycemia that likewise gives greater weight to very high-glucose than to high-glucose. These two components should be calculated and displayed separately, but they can also be combined into a single Glycemia Risk Index (GRI) that corresponds closely to the clinician rankings of the overall quality of glycemia (r = 0.95). The GRI can be displayed graphically on a GRI Grid with the hypoglycemia component on the horizontal axis and the hyperglycemia component on the vertical axis. Diagonal lines divide the graph into five zones (quintiles) corresponding to the best (0th to 20th percentile) to worst (81st to 100th percentile) overall quality of glycemia. The GRI Grid enables users to track sequential changes within an individual over time and compare groups of individuals. Conclusion: The GRI is a single-number summary of the quality of glycemia. Its hypoglycemia and hyperglycemia components provide actionable scores and a graphical display (the GRI Grid) that can be used by clinicians and researchers to determine the glycemic effects of prescribed and investigational treatments.
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| 3. |
- Gunbina, A. A., et al.
(författare)
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Spectral Response of Arrays of Half-wave and Electrically Small Antennas with SINIS Bolometers
- 2020
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Ingår i: Physics of the Solid State. - 1063-7834 .- 1090-6460. ; 62:9, s. 1604-1611
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Tidskriftsartikel (refereegranskat)abstract
- Two types arrays of annular half-wave and electrically small antennas with typical sizes of the elements corresponding to 1/10 of the wavelength at SubTHz band with integrated superconductor-insulator-normal metal-insulator-superconductor (SINIS) bolometers have been developed, fabricated and experimentally studied. We performed numerical modeling of the full structure and use additional reference channels in experimental studies to enhance the accuracy of the spectral response estimations of receiving arrays. In experiments three reference channels were used for normalization of the spectral response: a pyroelectric detector outside the cryostat, and two cold channels-a RuO(2)bolometer and on-chip thermometer comprising series array of NIS-junctions.
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| 4. |
- Tarasov, Mikhail, 1954, et al.
(författare)
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Cryogenic Mimim and Simis Microwave Detectors
- 2020
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Ingår i: Proceedings - 2020 7th All-Russian Microwave Conference, RMC 2020. ; , s. 25-27
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Konferensbidrag (refereegranskat)abstract
- Microwave detectors of the Metal-Insulator-Metal-Insulator-Metal (MIMIM) structure and the Superconductor-Insulator-Metal-Insulator-Superconductor (SIMIS) structure have been designed, fabricated and investigated. The difference of such samples was in external electrodes, MIMIM uses copper external electrodes, while SIMIS uses aluminum. Identical in dimensions MIMIM and SIMIS samples have been fabricated and experimentally studied in the temperature range of 0.1-2.7 K. Voltage and current response were measured at 300 GHz external irradiation using Backward Wave Oscillator (BWO). According to our estimates, the MIMIM current responsivity is 1.1·103 A/W in the case of a photon response and 4·104 A/W in the case of a bolometric response. The estimated noise equivalent power is in the range 2.5·10 18 W/v Hz to 1.2·10-19 W/vHz.
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| 5. |
- Tarasov, Michael, et al.
(författare)
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Non-Thermal Absorption and Quantum Efficiency of SINIS Bolometer
- 2021
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Ingår i: IEEE Transactions on Applied Superconductivity. - 1558-2515 .- 1051-8223. ; 31:5
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Tidskriftsartikel (refereegranskat)abstract
- We study mechanisms of absorption in two essentially different types of superconductor-insulator-normal metal-insulator-superconductor (SINIS) bolometers with absorber directly placed on Si wafer and with absorber suspended above the substrate. The figure of merit for quantum photon absorption is quantum efficiency equal to the number of detected electrons for one photon. The efficiency of absorption is dramatically dependent on phonon losses to substrate and electrodes, and electron energy losses to electrodes through tunnel junctions. The maximum quantum efficiency can approach n = hf/kT = 160 at f = 350 GHz T = 0.1 K, and current responsivity dI/dP = e/kT in quantum gain bolometer case, contrary to photon counter mode with quantum efficiency of n = 1 and responsivity dI/dP = e/hf. In experiments, we approach intrinsic quantum efficiency up to n = 80 electrons per photon in bolometer with suspended absorber, contrary to quantum efficiency of about one for absorber on the substrate. In the case of suspended Cu and Pd absorber, Kapitsa resistance protect from power leak to Al electrodes.
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| 6. |
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| 7. |
- Tarasov, M.A., et al.
(författare)
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Power load dependencies of cold electron bolometer optical response at 350 ghz
- 2014
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Ingår i: 25th International Sympsoium on Space Terahertz Technology, ISSTT 2014; Moscow; Russian Federation; 27 April 2014 through 30 April 2014. ; , s. 35-41
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Konferensbidrag (refereegranskat)abstract
- Cold electron bolometers integrated with twin-slot antennas have been designed and fabricated. Optical response was measured in 0.06-0.6 K temperature range using black body radiation source at temperature 2-15 K. The responsivity of 0.3109 V/W was measured at 2.7 K radiation temperature. The estimated ultimate dark responsivity at 100 mK can approach Sv=1010 V/W and reduces down to 1.1108 V/W at 300 mK for the sample with absorber volume of 510-20 m3. At high power load levels and low temperatures the changes of tunneling current, dynamic resistance and voltage response have been explained by non-thermal energy distribution of excited electrons. Distribution of excited electrons in such system is of none-Fermi type, electrons with energies of the order of 1 K tunnel from normal metal absorber to superconductor instead of relaxing down to thermal energy kTe. This effect can reduce quantum efficiency of bolometer from hf/kTph in ideal case down to single electron per signal quantum in the high power case.
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| 8. |
- Devereux, R. B., et al.
(författare)
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Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial
- 2004
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Ingår i: Circulation. - 1524-4539. ; 110:11, s. 1456-62
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: An echocardiographic substudy of the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial was designed to test the ability of losartan to reduce left ventricular (LV) mass more than atenolol. METHODS AND RESULTS: A total of 960 patients with essential hypertension and LV hypertrophy (LVH) on screening ECG were enrolled at centers in 7 countries and studied by echocardiography at baseline and after 1, 2, 3, 4, and 5 years' randomized therapy. Clinical examination and blinded readings of echocardiograms in 457 losartan-treated and 459 atenolol-treated participants with > or =1 follow-up measurement of LV mass index (LVMI) were used in an intention-to-treat analysis. Losartan-based therapy induced greater reduction in LVMI from baseline to the last available study than atenolol with adjustment for baseline LVMI and blood pressure and in-treatment pressure (-21.7+/-21.8 versus -17.7+/-19.6 g/m2; P=0.021). Greater LVMI reduction with losartan was observed in women and men, participants >65 or <65 years of age, and with mild or more severe baseline hypertrophy. The difference between treatment arms in LVH regression was due mainly to reduced concentricity of LV geometry in both groups and lesser increase in LV internal diameter in losartan-treated patients. CONCLUSIONS: Antihypertensive treatment with losartan, plus hydrochlorothiazide and other medications when needed for pressure control, resulted in greater LVH regression in patients with ECG LVH than conventional atenolol-based treatment. Thus, angiotensin receptor antagonism by losartan has superior efficacy for reversing LVH, a cardinal manifestation of hypertensive target organ damage.
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| 9. |
- Rastorgueva, V.S., et al.
(författare)
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The Gilaki Language
- 2012
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- This is a translation of the original book entitled: Giljanskij Jazyk. It includes an additional appendix containing an interlinearized version of the Gilaki texts. English translation editing and expanded content by Ronald M. LockwoodOriginal AbstractThis monograph presents a description of one of the insufficiently explored Iranian languages widespread in the Northern part of Iran (in the province of Gilan). A description of the phonetic and grammatical system of the Gilaki language is given therein. Texts (examples of conversational language and connected narrative) taken down by Gilaki authors now in the USSR are the basis of the grammatical analysis.At the end of the work the Gilaki texts and their translations into Russian are added.Ronald M. Lockwood's foreword Seeing that this book was a significant work on the Gilaki language, some years ago I sought to have it translated to English. I recognized the high quality of the research and believed the work to be one of the best of its kind on the subject. I undertook a complete reformatting and editing of the book so that it could be made available to the linguistic community.I decided to also undertake the task of interlinearizing all of the texts included in this work. In appendix A you will find the original Gilaki texts with the free translation immediately below each sentence. This differs from the original book in which each Gilaki text was followed by a free translation text. The free translation line is an English translation of the original Russian free translation. In appendix B you will find an interlinearized version of the texts. Three lines are provided; the vernacular divided into morphemes, the corresponding English glosses for the vernacular morphemes and a free translation line. In appendix B the English free translation has been revised as necessary to give a more accurate English free translation of the Gilaki vernacular.The body of the book has been reformatted to make it easier to read. Sections and subsections have been added. Example sentences have been formatted and listed as numbered examples. Numbered tables and figures have also been included. Note that for some example sentences no reference is given. This is because the sentence is not from the texts included in the appendices.In the online version of this book, I added extensive linking between the examples and the texts. The user can click on an example’s reference and be taken to the text containing that example in appendix A. From appendix A the user can click to see the corresponding interlinear example in appendix B. All of the language and gloss data has been color coded.
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