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- Johansson, Maria E, 1977, et al.
(författare)
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Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice
- 2014
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 44:10, s. 3081-3092
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Tidskriftsartikel (refereegranskat)abstract
- Atherosclerosis is an inflammatory disease associated with the activation of innate immune TLRs and nucleotide-binding oligomerization domain-containing protein (NOD)like receptor pathways. However, the function of most innate immune receptors in atherosclerosis remains unclear. Here, we show that NOD2 is a crucial innate immune receptor influencing vascular inflammation and atherosclerosis severity. 10-week stimulation with muramyl dipeptide (MDP), the NOD2 cognate ligand, aggravated atherosclerosis, as indicated by the augmented lesion burden, increased vascular inflammation and enlarged lipid-rich necrotic cores in Ldlr(-/-) mice. Myeloid-specific ablation of NOD2, but not its downstream kinase, receptor-interacting serine/threonine-protein kinase 2, restrained the expansion of the lipid-rich necrotic core in Ldlr(-/-) chimeric mice. In vitro stimulation of macrophages with MDP enhanced the uptake of oxidized low-density lipoprotein and impaired cholesterol efflux in concordance with upregulation of scavenger receptor A1/2 and downregulation of ATP-binding cassette transporter A1. Ex vivo stimulation of human carotid plaques with MDP led to increased activation of inflammatory signaling pathways p38 MAPK and NF-kappa B-mediated release of proinflammatory cytokines. Altogether, this study suggests that NOD2 contributes to the expansion of the lipid-rich necrotic core and promotes vascular inflammation in atherosclerosis.
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- Muller, S, et al.
(författare)
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Target 2035 - update on the quest for a probe for every protein
- 2022
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Ingår i: RSC medicinal chemistry. - : Royal Society of Chemistry (RSC). - 2632-8682. ; 13:1, s. 13-21
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. Target 2035 aims to develop a pharmacological modulator for every protein in the human proteome to fill this gap.
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Narratives Crossing Borders : The Dynamics of Cultural Interaction
- 2021
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- Which is the identity of a traveler who is constantly on the move between cultures and languages? What happens with stories when they are transmitted from one place to another, when they are retold, remade, translated and re-translated? What happens with the scholars themselves, when they try to grapple with the kaleidoscopic diversity of human expression in a constantly changing world? These and related questions are, if not given a definite answer, explored in the chapters of this anthology. Its overall topic, narratives that pass over national, language and ethnical borders include studies about transcultural novels, poetry, drama and the narratives of journalism. There is a broad geographic diversity, not only in the anthology as a whole, but also in each of the single contributions. This in turn demand a multitude of theoretical and methodological approaches, which cover a spectrum of concepts from such different sources as post-colonial studies, linguistics, religion, aesthetics, art and media studies, often going beyond the well-known Western frameworks. The works of authors like Miriam Toews, Yoko Tawada, Javier Moreno, Leila Abouela, Marguerite Duras, Kyoko Mori, Francesca Duranti, Donato Ndongo-Bidyogo, Rībi Hideo, and François Cheng are studied from a variety of perspectives. Other chapters deal with code-switching in West-african novels, border-crossing in the Japanese noh drama, translational anthologies of Italian literature, urban legends on the US-Mexico border, migration in German children's books, and war trauma in poetry. Most of the chapters are case studies, and may thus be of interest, not only for specialists, but also for the general reader.
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