| 1. |
- Abdellah, Tebani, et al.
(författare)
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Integration of molecular profiles in a longitudinal wellness profiling cohort.
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies andimmune cell profiling, complementedwith gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.
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| 2. |
- Almers, Peter, et al.
(författare)
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Exercises
- 2005
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Ingår i: Wireless Communications. - 9780470848883 - 047084888X - 0470848871 ; , s. 561-593
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Alvez, Maria Bueno, et al.
(författare)
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Next generation pan-cancer blood proteome profiling using proximity extension assay
- 2023
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. Here, we describe the use of next generation protein profiling to explore the proteome signature in blood across patients representing many of the major cancer types. Plasma profiles of 1463 proteins from more than 1400 cancer patients are measured in minute amounts of blood collected at the time of diagnosis and before treatment. An open access Disease Blood Atlas resource allows the exploration of the individual protein profiles in blood collected from the individual cancer patients. We also present studies in which classification models based on machine learning have been used for the identification of a set of proteins associated with each of the analyzed cancers. The implication for cancer precision medicine of next generation plasma profiling is discussed.
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| 4. |
- Bengtsson, Erik L, et al.
(författare)
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A Case Study on the Influence of Multiple Users on the Effective Channel in a Massive MIMO System
- 2019
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Ingår i: IEEE Wireless Communications Letters. - 2162-2337. ; , s. 1-6
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the importance of weak clusters when modeling a wireless massive MIMO channel. We do this by studying the influence of densely spaced terminals and the number of base-station antennas for a zero-forcing precoded massive MIMO system. In particular, we focus on the influence on the correlation and imbalance between the signals at the terminal antennas, the effective channel-gain, the eigenvalue distributions and the number of clusters.The study is based on measured radio-channels from terminal prototypes with integrated antennas connected to a massive MIMO testbed.We further evaluate the advantage of using block-diagonalized zero-forcing compared to conventional zero-forcing in a massive MIMO system. Unexpectedly, terminals with low antenna envelope correlation coefficient may benefit significantly from block-diagonal zero-forcing in a massive MIMO system.The main conclusion is that weaker clusters are important when modeling multi-user scenarios.
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| 5. |
- Bengtsson, Erik L., et al.
(författare)
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A Simulation Framework for Multiple-Antenna Terminals in 5G Massive MIMO Systems
- 2017
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Ingår i: IEEE Access. - 2169-3536. ; 5, s. 26819-26831
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Tidskriftsartikel (refereegranskat)abstract
- The recent interest in massive MIMO has spurred intensive work on massive MIMO channel modeling in contemporary literature. However, current models fail to take the characteristics of terminal antennas into account. There is no massive MIMO channel model available that can be used for evaluation of the influence of different antenna characteristics at the terminal side. In this paper, we provide a simulation framework that fills this gap. We evaluate the framework with antennas integrated into Sony Xperia handsets operating at 3.7 GHz as this spectrum is identified for the 5G new radio standard by 3GPP. The simulation results are compared with measured terminal performance when communicating with the Lund University’s massive MIMO testbed under the same loading conditions. Expressions are derived for comparison of the gain obtained from different diversity schemes computed from measured far-field antenna patterns. We conclude that the simulation framework yields results close to the measured ones and that the framework can be used for antenna evaluation for terminals in a practical precoded massive MIMO system.
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| 6. |
- Bengtsson, Erik L., et al.
(författare)
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Analysis of Transmission Schemes for Dual-Antenna Terminals in Massive MIMO Systems
- 2018
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Ingår i: 2018 25th International Conference on Telecommunications, ICT 2018. - 9781538623213 ; , s. 76-82
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Konferensbidrag (refereegranskat)abstract
- The overall system performance of massive MIMO is improved by equipping user terminals with multiple antennas. In this paper, we investigate transceiver designs for the case of a single downlink stream and in particular, we study the uplink pilot design. Moreover, we study the consequences of channel estimation errors at the base-station, and to what extent a dual-antenna terminal can get access to relevant channel statistics for optimization of the pilot signal. Gain expressions for comparison of different designs are derived. We verify the analytic results based on antennas integrated into Sony-Xperia handsets measured with the Lund University massive MIMO testbed. The measurements are performed at frequencies <6GHz since this part of the spectrum is a candidate for NR standard according to 3GPP.
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| 7. |
- Bengtsson, Erik L, et al.
(författare)
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Simulation of Multiple-Antenna Terminal Performance in Massive MIMO Systems based on Indoor Measurements
- 2020
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Ingår i: IEEE Transactions on Vehicular Technology. - 0018-9545. ; 69:1, s. 418-427
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Tidskriftsartikel (refereegranskat)abstract
- In massive MIMO systems the uplink pilot signalstransmitted by a terminal define the channel seen by the basestation. This gives the terminal some degree of freedom selectingan uplink pilot transmission strategy. In this paper, we investigatethe benefit of different pilot transmission strategies when increasingthe number of antennas in the terminal. Building on previouswork on a simulation framework for Multiple-antenna terminalsin 5G massive MIMO systems, this paper presents simulatedperformance results for various transmission schemes. The resultsare calibrated to reflect a real communication situation in a largeauditorium. Emulating the measurement set-up, we show that theframework can be tuned to generate channel distributions thatmatch measured data. Under generalized conditions, we performsimulations for different terminal transmission-strategies, bothrelated to single stream and multiple streams. All evaluations arebased on terminals with four antennas integrated into real SonyXperia smartphone-chassis, tuned to 3.7 GHz. The measurementsare conducted by using the Lund University Massive MIMOtestbed with its 100 antennas. The results clearly show theadvantage of increasing the antenna-count also at the terminalside in massive MIMO systems.
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| 8. |
- Bengtsson, Erik L, et al.
(författare)
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Transmission schemes for Multiple Antenna Terminals in Real Massive MIMO systems
- 2016
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Ingår i: 2016 IEEE Global Communications Conference (GLOBECOM). - 9781509013289 - 9781509013296
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Konferensbidrag (refereegranskat)abstract
- In massive MIMO performance evaluations it is often assumed that the terminal has a single antenna. The combination of multiple antennas in a terminal and massive MIMO precoding at the base station side can further improve overall system performance. We present measurement results for multi antenna terminals operating in different transmission schemes and how they perform under varying loading conditions. Gain expressions are derived that enable easy comparison between the transmission schemes. The evaluation is performed on realistic antennas integrated into Sony Xperia handsets tuned to 3.7~GHz and operated together with the Lund University massive MIMO (LuMaMi) test bed. It is concluded that the approach used in today's mobile systems, where up link and down link are addressed independently, will not provide the best performance. The performance can be improved by the selection of transmission schemes optimized for massive MIMO.
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| 9. |
- Bourdoux, Andre, et al.
(författare)
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D1.2 MaMi Channel Characteristics: Measurement Results
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This deliverable presents channel measurement results for the scenariosOpen exhibition and Crowded auditiorium. The measurement procedureand equipment are described. Massive MIMO (MaMi) channel characteristicsand key parameters are extracted and used in an extended COST 2100channel model for MaMi. The initial validation performed shows that themodel is capable of reproducing the statistics in terms of temporal behaviorof the user separability, singular value spread, capacity and sum-rate anddirectional characteristics. The model can be used for system and link levelMaMi simulations.
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| 10. |
- Edfors, Fredrik, et al.
(författare)
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Gene-specific correlation of RNA and protein levels in human cells and tissues
- 2016
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Ingår i: Molecular Systems Biology. - : EMBO. - 1744-4292 .- 1744-4292. ; 12:10
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Tidskriftsartikel (refereegranskat)abstract
- An important issue for molecular biology is to establish whether transcript levels of a given gene can be used as proxies for the corresponding protein levels. Here, we have developed a targeted proteomics approach for a set of human non-secreted proteins based on parallel reaction monitoring to measure, at steady-state conditions, absolute protein copy numbers across human tissues and cell lines and compared these levels with the corresponding mRNA levels using transcriptomics. The study shows that the transcript and protein levels do not correlate well unless a gene-specific RNA-to-protein (RTP) conversion factor independent of the tissue type is introduced, thus significantly enhancing the predictability of protein copy numbers from RNA levels. The results show that the RTP ratio varies significantly with a few hundred copies per mRNA molecule for some genes to several hundred thousands of protein copies per mRNA molecule for others. In conclusion, our data suggest that transcriptome analysis can be used as a tool to predict the protein copy numbers per cell, thus forming an attractive link between the field of genomics and proteomics.
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