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| 2. |
- Djerf, K, et al.
(författare)
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A simplified roentgen stereophotogrammetric method. Analysis of small movements between the prosthetic stem and the femur after total hip replacement.
- 1987
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Ingår i: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 28:5, s. 603-606
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Tidskriftsartikel (refereegranskat)abstract
- A simplified roentgen stereophotogrammetric method is described. It is based on the use of a 50 mm thick reference plate consisting of a carbon-fibre-reinforced polyester box. The patient is placed directly on this box, which makes the methods less cumbersome and more suitable for routine use. The method has been tested in a model experiment designed for detecting small movements between femur and prosthesis at an early stage after total hip replacement. The head and two hemispheres on the prosthesis and three small tantalum balls inserted in the femur serve as reference points. The model experiment now reported shows that the method has acceptable precision.
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| 3. |
- Edholm, David, et al.
(författare)
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Importance of pouch size in laparoscopic Roux-en-Y gastric bypass : a cohort study of 14,168 patients
- 2016
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Ingår i: Surgical Endoscopy. - : Springer Science and Business Media LLC. - 0930-2794 .- 1432-2218. ; 30:5, s. 2011-2015
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) is one of the most common bariatric procedures worldwide, but the importance of gastric pouch size is still under debate. We have studied how pouch size affects risk of marginal ulcer and excess body mass index loss (EBMIL%) at 6 weeks and 1 year postoperatively.METHODS: Scandinavian Obesity Surgery Registry included 14,168 LRYGB patients with linear stapled gastrojejunostomies, having complete pre- and postoperative data concerning length of stapler needed to complete the gastric pouch, incidence of marginal ulcers and weight loss. LRYGB technique in Sweden is highly standardized, and total length of stapler was used as a proxy for pouch size.RESULTS: Mean length of stapler used for the pouch was 145 mm. At 1 year, symptomatic marginal ulcers were noted in 0.9 % of the patients. The relative risk of marginal ulcer increased by 14 % (95 % confidence interval 9-20 %), for each centimeter of stapler used for the pouch. Body mass index (BMI) was reduced from 42.4 ± 5.1 to 36.1 kg/m(2) at 6 weeks and 28.9 kg/m(2) at 1 year. The total length of stapler predicted EBMIL% at 6 weeks but not at 1 year. Female gender, low preoperative BMI, young age and absence of diabetes predicted better EBMIL% at 1 year.CONCLUSION: A smaller pouch reduces the risk of marginal ulcers, but does not predict better weight loss at 1 year. Additional stapling should be avoided as each extra centimeter increases the relative risk of marginal ulcers by 14 %.
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| 4. |
- Edholm, David, et al.
(författare)
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Very low risk of short bowel after Roux-en-Y gastric bypass : a large nationwide Swedish cohort study
- 2024
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Ingår i: Surgery for Obesity and Related Diseases. - : Elsevier. - 1550-7289 .- 1878-7533. ; 20:4, s. 362-366
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Roux-en-Y gastric bypass (RYGB) is one of the most common bariatric procedures. Internal herniation may lead to small bowel ischemia requiring small bowel resection, resulting in short bowel syndrome. OBJECTIVE: To determine the incidence of extensive small bowel resection in patients operated with RYGB. We also aimed to look for early clinical warning signs among patients requiring extensive small bowel resection.SETTING: Cohort from national quality registers.METHODS: All patients having undergone RYGB between January 2007 to June 2019 were analyzed in the Scandinavian Obesity Surgery Registry (SOReg). We identified patients with small bowel obstruction (SBO) for whom small bowel resection was necessary. Additionally, we assessed clinical signs in these patients.RESULTS: The study included 57,255 patients having undergone RYGB. Closure of the mesenteric openings was performed in 78%. Surgery for SBO was required in 3659 (6%) of patients, and small bowel resection in 188 (.3%). Extensive small bowel resection, resulting in less than 1.5 meters of remaining small bowel, was required in 7 patients (.01%). All patients with extensive small bowel resection presented with abdominal pain and had confirmed internal herniation as the cause of the small bowel resection, and 2 of 7 patients died. Closure of mesenteric defects was not associated with a reduction in overall small bowel resection rates (P = .89)CONCLUSION: Surgery for SBO after RYGB was common (6%). The risk of extensive small bowel resection leading to short bowel was low (.01%). Patients with abdominal pain after RYGB should be assessed for internal hernia, as it can be devastating.
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| 5. |
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| 6. |
- Edholm, Peter, 1974, et al.
(författare)
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Robust Tolerance Design Applied on Robot Concept Development
- 2010
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Ingår i: 8th International NordDesign Conference, NordDesign 2010; Goteborg; Sweden; 25 August 2010 through 27 August 2010. ; , s. 21-30
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Konferensbidrag (refereegranskat)abstract
- A robust tolerance design concept based on locating schemes (for example, used in the car industry for sheet metal parts) and the methods and tools connected to that concept are applied on a new robot development. A case study of a robot assembly is performed in a new robot development project. The robot is mainly designed using machined parts, and traditionally these parts are toleranced using feature-to-feature based tolerances and linear dimensioning. The goal of this case study is to see if there are any advantages to using a new approach when designing robots to enable high geometric quality at a low cost. With limitations, the study shows that it seems possible to effectively use the tolerance design concept in robot development with assemblies consisting of machined parts.
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| 7. |
- Levandowski, Christoffer E, 1984, et al.
(författare)
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PLM Architecture for Optimization of Geometrical Interfaces in a Product Platform
- 2011
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Ingår i: Proceedings of the ASME 2011; International Design Engineering Technical Conferences & Computers and Information in Engineering Conference (Volume 2: 31st Computers and Information in Engineering Conference, Parts A and B ). - 9780791854792 ; :Paper no. DETC2011-47801, s. 1237-1244
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Konferensbidrag (refereegranskat)abstract
- Product platforms can be used as an enabler for offering a wide variety of products to the market, while keeping the development cost down. Reusing knowledge in new designs is a key concept of product platforms, whether it is about reusing entire parts, or reusing ideas and concepts. The Configurable Component (CC) concept is one way of describing a product platform, and is based on autonomous subsystems that are not fixed, but have a bandwidth within which they can vary. These systems are configured to fit the set of requirements resulting in product variants. Product Lifecycle Management (PLM) as a complementing business strategy deals with integrating processes, information, systems and people across the product lifecycle to support the development of complex products.This paper describes a case study where the CC concept is successfully implemented in a PLM environment to allow configuration of the systems in relation to each other. The focal point of this paper is configuration of the geometrical interfaces between sub systems. A car door from a Swedish car manufacturer, known for the tight fit in assembly, is used as an example. In this case, there are two requirements on the assembly. First, the assembly cannot be far from nominal, thus requiring robust interfaces between the ingoing parts. Second, the window must be mountable. The result is a PLM architecture with a Product Data Management (PDM) system, a Computer Aided Design (CAD) tool, two Computer Aided Engineering (CAE) tools and a configurator, all integrated.
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| 8. |
- Miliotis, Tasso, et al.
(författare)
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Protein identification platform utilizing micro dispensing technology interfaced to matrix-assisted laser desorption ionization time-of-flight mass spectrometry
- 2000
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Ingår i: Journal of Chromatography A. - 0021-9673. ; 886:1-2, s. 99-110
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Tidskriftsartikel (refereegranskat)abstract
- An integrated protein microcharacterization/identification platform has been developed. The system has been designed to allow a high flexibility in order to tackle challenging analytical problems. The platform comprises a cooled microautosampler, an integrated system for microcolumn HPLC, and a capillary reversed-phase column that is interfaced to matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) system via a low internal volume flow-through microdispenser. The chromatographic separation is continuously transferred onto a MALDI target plate as discrete spots as the dispenser ejects bursts of droplets of the column effluent in a precise array pattern. A refrigerated microfraction collector was coupled to the outlet of the flow-through microdispenser enabling enrichment and re-analysis of interesting fractions. The use of target plates pre-coated with matrix simplified and increased the robustness of the system. By including a separation step prior to the MALDI-TOF-MS analysis and hereby minimizing suppression effects allowed us to obtain higher sequence coverage of proteins compared to conventional MALDI sample preparation methodology. Additionally, synthetic peptides corresponding to autophosphorylated forms of the tryptic fragment 485-496 (ALGADDSYYTAR) of tyrosine kinase ZAP-70 were identified at sensitivities reaching 150 amol. Copyright (C) 2000 Elsevier Science B.V.
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| 9. |
- Miliotis, Tasso, et al.
(författare)
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Ready-made matrix-assisted laser desorption/ionization target plates coated with thin matrix layer for automated sample deposition in high-density array format.
- 2002
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Ingår i: Rapid Communications in Mass Spectrometry. - : Wiley. - 1097-0231 .- 0951-4198. ; 16:2, s. 117-126
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Tidskriftsartikel (refereegranskat)abstract
- The methodology for ready-made matrix-assisted laser desorption/ionization (MALDI) target plates covered with an optimized thin layer consisting of matrix and nitrocellulose has been developed. Piezoelectric microdispensing enabled sample depositions in a high-density array format of 2000 sample depositions on a conventionally sized target plate (45 x 47 mm). The sample depositions were made reproducibly in a fully automated mode by using an in-house developed computer-controlled piezoelectric flow-through microdispenser. Additionally, the piezoelectric technique facilitated significant analyte enrichment that increased the detection sensitivity. The MS signal was obtained rapidly, generally within ten laser pulses. An airbrush device was used to generate a fine spray of matrix and nitrocellulose dissolved in acetone. The acetone evaporated instantly when reaching the target plate leaving the entire surface with a thin and uniform matrix/nitrocellulose coating consisting of very small crystals of matrix embedded in the nitrocellulose. These crystals acted as a seed-layer on subsequent analyte depositions, rendering homogeneous sample spots when using alpha-cyano-4-hydroxycinnamic acid (CHCA) as matrix. The relative standard deviation of the signal intensity between spots was (20-30)% (n = 30). The detection sensitivity was improved by restricting the sample spot diameter to 300 microm. The spot size was affected by the deposition rate and the evaporation rate of the dispensed sample volume. Mass spectra of a 25-amol peptide mixture deposition were successfully recorded.
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| 10. |
- Olsen, Sarah H., et al.
(författare)
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Control of self-heating in thin virtual substrate strained Si MOSFETs
- 2006
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Ingår i: IEEE Transactions on Electron Devices. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9383 .- 1557-9646. ; 53:9, s. 2296-2305
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the first results and analysis of strained Si n-channel MOSFETs fabricated on thin SiGe virtual substrates. Significant improvements in electrical performance are demonstrated compared with Si control devices. The impact of SiGe device self-heating is compared for strained Si MOSFETs fabricated on thin and thick virtual substrates. This paper demonstrates that by using high-quality thin virtual substrates,,the compromised performance enhancements commonly observed in short-gate-length MOSFETs and high-bias conditions due to self-heating in conventional thick virtual substrate devices are eradicated. The devices were fabricated with a 2.8-nm gate oxide and included NiSi to reduce the parasitic series resistance. The strained layers grown on the novel substrates comprising 20% Ge did not relax during fabrication. Good ON-state performance, OFF-state performance, and cross-wafer uniformity are demonstrated. The results show that thin virtual substrates have the potential to circumvent the major issues associated with conventional virtual substrate technology. A promising solution for realizing high-performance strained Si devices suitable for a wide range of applications is thus presented.
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