| 1. |
- Edin, Carl, et al.
(författare)
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Ectopic fat is associated with cardiac remodeling - A comprehensive assessment of regional fat depots in type 2 diabetes using multi-parametric MRI.
- 2022
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Ingår i: Frontiers in Cardiovascular Medicine. - : Frontiers Media SA. - 2297-055X. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Different regional depots of fat have distinct metabolic properties and may relate differently to adverse cardiac remodeling. We sought to quantify regional depots of body fat and to investigate their relationship to cardiac structure and function in Type 2 Diabetes (T2D) and controls.Methods: From the SCAPIS cohort in Linköping, Sweden, we recruited 92 subjects (35% female, mean age 59.5 ± 4.6 years): 46 with T2D and 46 matched controls. In addition to the core SCAPIS data collection, participants underwent a comprehensive magnetic resonance imaging examination at 1.5 T for assessment of left ventricular (LV) structure and function (end-diastolic volume, mass, concentricity, ejection fraction), as well as regional body composition (liver proton density fat fraction, visceral adipose tissue, abdominal subcutaneous adipose tissue, thigh muscle fat infiltration, fat tissue-free thigh muscle volume and epicardial adipose tissue).Results: Compared to the control group, the T2D group had increased: visceral adipose tissue volume index (P < 0.001), liver fat percentage (P < 0.001), thigh muscle fat infiltration percentage (P = 0.02), LV concentricity (P < 0.001) and LV E/e'-ratio (P < 0.001). In a multiple linear regression analysis, a negative association between liver fat percentage and LV mass (St Beta -0.23, P < 0.05) as well as LV end-diastolic volume (St Beta -0.27, P < 0.05) was found. Epicardial adipose tissue volume and abdominal subcutaneous adipose tissue volume index were the only parameters of fat associated with LV diastolic dysfunction (E/e'-ratio) (St Beta 0.24, P < 0.05; St Beta 0.34, P < 0.01, respectively). In a multivariate logistic regression analysis, only visceral adipose tissue volume index was significantly associated with T2D, with an odds ratio for T2D of 3.01 (95% CI 1.28-7.05, P < 0.05) per L/m2 increase in visceral adipose tissue volume.Conclusions: Ectopic fat is predominantly associated with cardiac remodeling, independently of type 2 diabetes. Intriguingly, liver fat appears to be related to LV structure independently of VAT, while epicardial fat is linked to impaired LV diastolic function. Visceral fat is associated with T2D independently of liver fat and abdominal subcutaneous adipose tissue.
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| 2. |
- Edin, Carl, et al.
(författare)
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Liver fibrosis is associated with left ventricular remodeling : insight into the liver-heart axis
- 2024
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Ingår i: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084.
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Tidskriftsartikel (refereegranskat)abstract
- Objective: In non-alcoholic fatty liver disease (NAFLD), liver fibrosis is the strongest predictor of adverse outcomes. We sought to investigate the relationship between liver fibrosis and cardiac remodeling in participants from the general population using magnetic resonance imaging (MRI), as well as explore potential mechanistic pathways by analyzing circulating cardiovascular biomarkers.Methods: In this cross-sectional study, we prospectively included participants with type 2 diabetes and individually matched controls from the SCAPIS (Swedish CArdioPulmonary bioImage Study) cohort in Linköping, Sweden. Between November 2017 and July 2018, participants underwent MRI at 1.5 Tesla for quantification of liver proton density fat fraction (spectroscopy), liver fibrosis (stiffness from elastography), left ventricular (LV) structure and function, as well as myocardial native T1 mapping. We analyzed 278 circulating cardiovascular biomarkers using a Bayesian statistica lapproach.Results: In total, 92 participants were enrolled (mean age 59.5 ± 4.6 years, 32 women). The mean liver stiffness was 2.1 ± 0.4 kPa. 53 participants displayed hepatic steatosis. LV concentricity increased across quartiles of liver stiffness. Neither liver fat nor liver stiffness displayed any relationships to myocardial tissue characteristics (native T1). In a regression analysis, liver stiffness was related to increased LV concentricity. This association was independent of diabetes and liver fat (Beta = 0.26, p = 0.0053), but was attenuated (Beta = 0.17, p = 0.077) when also adjusting for circulating levels of interleukin-1 receptor type 2.Conclusion: MRI reveals that liver fibrosis is associated to structural LV remodeling, in terms of increased concentricity, in participants from the general population. This relationship could involve the interleukin-1 signaling.
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| 3. |
- Ahmad, Irma, et al.
(författare)
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High prevalence of persistent symptoms and reduced health-related quality of life 6 months after COVID-19
- 2023
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Ingår i: Frontiers In Public Health. - : Frontiers Media S.A.. - 2296-2565. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The long-term sequelae after COVID-19 constitute a challenge to public health and increased knowledge is needed. We investigated the prevalence of self-reported persistent symptoms and reduced health-related quality of life (HRQoL) in relation to functional exercise capacity, 6 months after infection, and explored risk factors for COVID-19 sequalae.METHODS: This was a prospective, multicenter, cohort study including 434 patients. At 6 months, physical exercise capacity was assessed by a 1-minute sit-to-stand test (1MSTST) and persistent symptoms were reported and HRQoL was evaluated through the EuroQol 5-level 5-dimension (EQ-5D-5L) questionnaire. Patients with both persistent symptoms and reduced HRQoL were classified into a new definition of post-acute COVID syndrome, PACS+. Risk factors for developing persistent symptoms, reduced HRQoL and PACS+ were identified by multivariable Poisson regression.RESULTS: Persistent symptoms were experienced by 79% of hospitalized, and 59% of non-hospitalized patients at 6 months. Hospitalized patients had a higher prevalence of self-assessed reduced overall health (28 vs. 12%) and PACS+ (31 vs. 11%). PACS+ was associated with reduced exercise capacity but not with abnormal pulse/desaturation during 1MSTST. Hospitalization was the most important independent risk factor for developing persistent symptoms, reduced overall health and PACS+.CONCLUSION: Persistent symptoms and reduced HRQoL are common among COVID-19 survivors, but abnormal pulse and peripheral saturation during exercise could not distinguish patients with PACS+. Patients with severe infection requiring hospitalization were more likely to develop PACS+, hence these patients should be prioritized for clinical follow-up after COVID-19.
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| 4. |
- Björsell, Tove, et al.
(författare)
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Risk factors for impaired respiratory function post COVID-19 : A prospective cohort study of nonhospitalized and hospitalized patients
- 2023
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Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell Publishing Inc.. - 0954-6820 .- 1365-2796. ; 293:5, s. 600-614
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Severe COVID-19 increases the risk for long-term respiratory impairment, but data after mild COVID-19 are scarce. Our aims were to determine risk factors for reduced respiratory function 3-6 months after COVID-19 infection and to investigate if reduced respiratory function would relate to impairment of exercise performance and breathlessness.METHODS: Patients with COVID-19 were enrolled at the University Hospitals of Umeå and Örebro, and Karlstad Central Hospital, Sweden. Disease severity was defined as mild (nonhospitalized), moderate (hospitalized with or without oxygen treatment), and severe (intensive care). Spirometry, including diffusion capacity (DLCO ), was performed 3-6 months after hospital discharge or study enrollment (for nonhospitalized patients). Breathlessness (defined as ≥1 according to the modified Medical Research Council scale) and functional exercise capacity (1-min sit-to-stand test; 1-MSTST) were assessed.RESULTS: Between April 2020 and May 2021, 337 patients were enrolled in the study. Forced vital capacity and DLCO were significantly lower in patients with severe COVID-19. Among hospitalized patients, 20% had reduced DLCO , versus 4% in nonhospitalized. Breathlessness was found in 40.6% of the participants and was associated with impaired DLCO . A pathological desaturation or heart rate response was observed in 17% of participants during the 1-MSTST. However, this response was not associated with reduced DLCO .CONCLUSION: Reduced DLCO was the major respiratory impairment 3-6 months following COVID-19, with hospitalization as the most important risk factor. The lack of association between impaired DLCO and pathological physiological responses to exertion suggests that these physiological responses are not primarily related to decreased lung function.
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| 5. |
- Carling, Gerd, et al.
(författare)
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DiACL : Diachronic Atlas of Comparative Linguistics
- 2017
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- DiACL is an open access database with lexical and typological/morphosyntactic data for historical, comparative and phylogenetic linguistics. It contains data from 500 languages of 18 families, divided into three macro-areas: Eurasia, Pacific, and the Amazon.
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| 6. |
- Christensson, Johan, 1984-
(författare)
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Teacher Identity as Discourse : A Case Study of Students in Swedish Teacher Education
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis comprises three separate studies that together explore how Swedish student teachers construct or produce professional identity in interaction while navigating different institutional and professional instances of teacher education. As a discourse analytical contribution to research on teacher identity, the main theoretical framework is mediated discourse theory (e.g. Scollon 2001a). For data construction and analysis in the studies, different parts of the two related methodologies of nexus analysis (Scollon & Scollon 2004) and multimodal (inter)action analysis (Norris 2011) are employed. Constructed through an ethnographic approach, the interactional data consist of audio and video recordings of interaction in instances from three different components of a Swedish teacher education program: a rhetoric course, a bachelor thesis course in history and teaching placement. Furthermore, the data include observational field notes and interviews, as well as resources used by the participants, primarily written texts. Taking place early on in teacher education, Study I focuses on student teachers performing oral presentations under the fictitious presumption that they are speaking as teachers. Employing the notion of communicative project (Linell 1998), the empirical aim of the study is to shed light on how student teachers manage institutional affordances and constraints affecting interactional role shifts from student teacher to teacher. In Study II, three student teachers are writing their bachelor theses in the subject of history, and the study focuses on the interactional production of teacher identity of one of the students during seminars. While partly being a methodological study, Study II empirically explores how student teachers interactionally relate to their future profession in an academic disciplinary setting, highlighting which actors and institutions are involved in the production of professional identity. Finally, Study III concentrates on a student teacher during his final teaching placement. Focusing on previous experiences resemiotized as stories, Study III highlights how discourse re-emerging from the historical body (Nishida 1958) can be used in interaction in producing identity. The results suggest that the production of teacher identity by the student teachers is a co-operative and communicative task, where previous experiences as well as an anticipatory perspective on the teaching profession are important features. The three studies identify different resources that can be used and adapted by students to suit different purposes in professional identity production, described as textual resources, embodied resources, and narrative resources. In turn, the different uses of such resources motivate the need for studying identity in interaction with an approach where ethnographic and sociocultural knowledge is part of the analysis. The creative use of resources in identity production highlights that students use knowledge and experience linked to academic and professional as well as everyday discourse in producing professional identity. Presuming an interest in opportunities for student teachers to develop professional identity during their education, it appears fruitful to reflect upon how potential resources are designed and implemented in teacher education, and how institutional affordances and constraints affect the possibilities of using them.
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| 7. |
- Dahlberg, Matz, 1966-, et al.
(författare)
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Effects of the COVID-19 pandemic on population mobility under mild policies : Causal evidence from Sweden
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Sweden has adopted far less restrictive social distancing policies than most countries following the COVID-19 pandemic (1–7). This paper uses data on all mobile phone users, from one major Swedish mobile phone network, to examine the impact of the Coronavirus outbreak under the Swedish mild recommendations and restrictions regime on individual mobility and if changes in geographical mobility vary over different socio-economic strata. Having access to data for January-March in both 2019 and 2020 enables the estimation of causal effects of the COVID-19 outbreak by adopting a Difference-in-Differences research design. The paper reaches four main conclusions: (i) The daytime population in residential areas increased significantly (64 percent average increase); (ii) The daytime presence in industrial and commercial areas decreased significantly (33 percent average decrease); (iii) The distance individuals move from their homes during a day was substantially reduced (38 percent decrease in the maximum distance moved and 36 percent increase in share of individuals 2 who move less than one kilometer from home); (iv) Similar reductions in mobility were found for residents in areas with different socioeconomic and demographic characteristics. These results show that mild government policies can compel people to adopt social distancing behavior.
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| 8. |
- Edin Anders, Ingelman Gunnar, Rathsman Johan
(författare)
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LEPTO 6.5 - A Monte Carlo generator for deep inelastic lepton-nucleon scattering
- 1997
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Ingår i: COMPUTER PHYSICS COMMUNICATIONS. - : ELSEVIER SCIENCE BV. - 0010-4655. ; 101:1-2, s. 108-134
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Tidskriftsartikel (refereegranskat)abstract
- Physics and programming aspects are discussed for a Fortran 77 Monte Carlo program to simulate complete events in deep inelastic lepton-nucleon scattering. The parton level interaction is based on the standard model electroweak cross sections, which are f
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| 9. |
- Edin Anders, Ingelman Gunnar, Rathsman Johan
(författare)
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Quarkonium production at the Fermilab Tevatron through soft color interactions
- 1997
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Ingår i: PHYSICAL REVIEW D. - : AMER INST PHYSICS. - 0556-2821. ; 56:11, s. 7317-7320
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Tidskriftsartikel (refereegranskat)abstract
- The direct charmonium and bottomonium production rate observed at high p(perpendicular to) in p (p) over bar collisions at the Fermilab Tevatron is factors of 10 larger than predictions based on conventional perturbative QCD. We show that this excess can
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| 10. |
- Edin Anders, Ingelman Gunnar, Rathsman Johan
(författare)
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Rapidity Gaps in DIS through Soft Colour Interactions
- 1995
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Ingår i: In proc. of workshop `DIS and QCD', Paris, April 1995.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- We present a new mechanism for the creation of large rapidity gaps in DIS events at HERA. Soft colour interactions between perturbatively produced partons and colour-charges in the proton remnant, modifies the colour structure for hadronization giving col
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