| 1. |
- Andersson, Daniel, 1977-
(författare)
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Fega pojkar pussar aldrig vackra flickor : Könsrelaterade ordspråk i nordnorrländsk agrarmiljö belysta ur språkligt och kulturellt perspektiv.
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation deals with 199 gender related proverbs that were collected in northern Sweden and were used in an agrarian environment, approximately between the beginning of the 19th century and the beginning of the 20th. The conceptions of gender which these proverbs convey also belong to the same time range and place.The aim of this dissertation is to find out which conceptions of gender that is conveyed by proverbs in an older agrarian environment in northern Sweden. In order to achieve this aim the following question is examined: What conceptions are found in the proverb material of the cultural category woman, the cultural category man and of the relationship between these categories?As a base for an interpretation of the proverbs, which are written in various Swedish dialects, a linguistic analysis is carried out. The interpretation is then formed through a concept that was developed by Kirshenblatt-Gimblett (1982); namely, base meaning. This concept relates to the shared meaning of a proverb by a group of people. The proverbs that include metaphors and similes are analyzed with a method that is developed from the cognitive linguistic theory of blending (Fauconnier & Turner 1996, 1998).The proverb material is sorted in three analytical categories, and presented in separate chapters: Chapter four, The Marriage Market (Äktenskapsmarknaden), chapter five: The Household (Hushållet) and chapter six, Sexuality (Sexualiteten). These categories are in turn divided into sub categories.One example of a salient conceptions of gender that is found in the category The Marriage Market is that the man chooses a woman, not the other way around. One example of a central conception in the category The Household is that the man earns money and supply other resources and the woman takes care of these resources. The significance of the conceptions of male and female sexuality is that they convey the difficulty in controlling a virulent male sexuality.The gender conceptions are analysed as part of a system of gender hegemony and a cultural model of the successful household is suggested based on the proverb material.
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| 2. |
- Ebersole, Charles R., et al.
(författare)
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Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability
- 2020
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Ingår i: Advances in Methods and Practices in Psychological Science. - : Sage. - 2515-2467 .- 2515-2459. ; 3:3, s. 309-331
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Tidskriftsartikel (refereegranskat)abstract
- Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect (p < .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3-9; median total sample = 1,279.5, range = 276-3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (Delta r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols (r = .05) was similar to that of the RP:P protocols (r = .04) and the original RP:P replications (r = .11), and smaller than that of the original studies (r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00-.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19-.50).
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| 3. |
- Haiman, Christopher A., et al.
(författare)
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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:12, s. 61-1210
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Tidskriftsartikel (refereegranskat)abstract
- Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 x 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 x 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 x 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
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| 4. |
- Andersson, Daniel, 1977-, et al.
(författare)
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Att synliggöra samiska ortnamn i Sverige : riktlinjer, praxis och vägar framåt
- 2021
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Ingår i: Navn på minoritetsspråk i muntlig og skriftlige sammenhenger. - Guovdageaidnu : Sámi allaskuvla. - 9789172761001 - 9788273670540 ; , s. 211-224
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Konferensbidrag (refereegranskat)abstract
- Making Sami place-names visible in Sweden: guidelines, practice and ways forwardIn this article, the authors illuminate the process in Sweden when a Sami place-name is considered for inclusion in the official place-name database, which in turn is a prerequisite for the name being made visible in the linguistic landscape through its use on road signs. Based on some problematic aspects of the current process, the authors argue for a revised set of guidelines for working with Sami place-names in Sweden, taking into account the colonial history and ongoing revitalization efforts. Furthermore, it is proposed that increased local participation in place-name processes could be beneficial to the work of finding the right name form, and to gain support from the name users.
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| 5. |
- Andersson, Daniel, 1977-, et al.
(författare)
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Language and space in Northern Spaces
- 2017
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Ingår i: Journal of Northern Studies. - : Umeå University; The Royal Skyttean Society. - 1654-5915 .- 2004-4658. ; 11:1, s. 7-9
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Archambault, Alexi N., et al.
(författare)
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Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer
- 2020
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Ingår i: Gastroenterology. - : Elsevier BV. - 0016-5085 .- 1528-0012. ; 158:5, s. 1274-1286.e12
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC.METHODS: We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 2019. Participants were pooled from 3 large consortia that provided clinical and genotyping data: the Colon Cancer Family Registry, the Colorectal Transdisciplinary Study, and the Genetics and Epidemiology of Colorectal Cancer Consortium and were all of genetically defined European descent. Findings were replicated in an independent cohort of 72,573 participants.RESULTS: Overall associations with CRC per standard deviation of PRS were significant for early-onset cancer, and were stronger compared with late-onset cancer (P for interaction = .01); when we compared the highest PRS quartile with the lowest, risk increased 3.7-fold for early-onset CRC (95% CI 3.28-4.24) vs 2.9-fold for late-onset CRC (95% CI 2.80-3.04). This association was strongest for participants without a first-degree family history of CRC (P for interaction = 5.61 x 10(-5)). When we compared the highest with the lowest quartiles in this group, risk increased 4.3-fold for early-onset CRC (95% CI 3.61-5.01) vs 2.9-fold for late-onset CRC (95% CI 2.70-3.00). Sensitivity analyses were consistent with these findings.CONCLUSIONS: In an analysis of associations with CRC per standard deviation of PRS, we found the cumulative burden of CRC-associated common genetic variants to associate with early-onset cancer, and to be more strongly associated with early-onset than late-onset cancer, particularly in the absence of CRC family history. Analyses of PRS, along with environmental and lifestyle risk factors, might identify younger individuals who would benefit from preventive measures.
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| 7. |
- Blomberg, Carl, et al.
(författare)
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Randomized Trials of Systemic Medically-treated Malignant Mesothelioma : A Systematic Review
- 2015
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 35:5, s. 2493-2501
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Forskningsöversikt (refereegranskat)abstract
- Malignant pleural mesothelioma (MPM) is a rare but aggressive malignancy mainly localized to the pleura. Malignant mesothelioma grows highly invasive into surrounding tissue and has a low tendency to metastasize. The median overall survival (OS) of locally advanced or metastatic disease without treatment is 4-13 months but, during recent years, improvement in survival has been achieved since treatment for patients with mesothelioma has improved with better palliative care, systemic medical treatment, surgery and improved diagnostics methods. The present review aims at describing available data from randomized trials considering systemic medical treatment for this patient category.
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| 8. |
- Chen, Zhishan, et al.
(författare)
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Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
- 2024
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
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| 9. |
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| 10. |
- Edlund, Jens, Docent/Associate Professor, 1967-, et al.
(författare)
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A Multimodal Digital Humanities Study of Terrorism in Swedish Politics: An Interdisciplinary Mixed Methods Project on the Configuration of Terrorism in Parliamentary Debates, Legislation, and Policy Networks 1968–2018
- 2022
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Ingår i: Intelligent Systems and Applications. Proceedings of the 2021 Intelligent Systems Conference, September 2–3, 2021 / Arai K. (eds). - Cham : Springer. - 2367-3370 .- 2367-3389. - 9783030821951 ; , s. 435-449
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Konferensbidrag (refereegranskat)abstract
- This paper presents the design of one of Sweden’s largest digital humanities projects, SweTerror, that through an interdisciplinary multi-modal methodological approach develops an extensive speech-to-text digital HSS resource. SweTerror makes a major contribution to the study of terrorism in Sweden through a comprehensive mixed methods study of the political discourse on terrorism since the late 1960s. Drawing on artificial intelligence in the form of state-of-the-art language and speech technology, it systematically analyses all forms of relevant parliamentary utterances. It explores and curates an exhaustive but understudied multi-modal collection of primary sources of central relevance to Swedish democracy: the audio recordings of the Swedish Parliament’s debates. The project studies the framing of terrorism both as policy discourse and enacted politics, examining semantic and emotive components of the parliamentary discourse on terrorism as well as major actors and social networks involved. It covers political responses to a range of terrorism-related issues as well as factors influencing policy-makers’ engagement, including political affiliations and gender. SweTerror also develops an online research portal, featuring the complete research material and searchable audio made readily accessible for further exploration. Long-term, the project establishes a model for combining extraction technologies (speech recognition and analysis) for audiovisual parliamentary data with text mining and HSS interpretive methods and the portal is designed to serve as a prototype for other similar projects.
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