| 1. |
- Johansson, Björn, 1975, et al.
(författare)
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Challenges and opportunities to advance manufacturing research for sustainable battery life cycles
- 2024
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Ingår i: Frontiers in Manufacturing Technology. - 2813-0359. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Advanced manufacturing research for sustainable battery life cycles is of utmost importance to reach net zero carbon emissions (European Commission, 2023a) as well as several of the United Nations Sustainable Development Goals (UNSDGs), for example: 30% reduction of CO2 emission, 10 million job opportunities and access to electricity for 600 million people (World Economic Forum, 2019). This editorial paper highlights international motivations for pursuing more sustainable manufacturing practices and discusses key research topics in battery manufacturing. Batteries will be central to our sustainable future as generation and storage become key components to on-demand energy supply. Four underlying themes are identified to address industrial needs in this field: 1. Digitalizing and automating production capabilities: data-driven solutions for production quality, smart maintenance, automation, and human factors, 2. Human-centric production: extended reality for operator support and skills development, 3. Circular battery life cycles: circular battery systems supported by service-based and other novel business models, 4. Future topics for battery value chains: increased industrial resilience and transparency with digital product passports, and next-generation battery chemistries. Challenges and opportunities along these themes are highlighted for transforming battery value chains through circularity and more sustainable production, with a particular emphasis on lithium-ion batteries (LIB). The paper concludes with directions for further research to advance a circular and sustainable battery value chain through utilizing the full potential of digitalization realising a cleaner, more energy-efficient society.
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| 2. |
- Karlsson, Björn, et al.
(författare)
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NORDIC COURSE DEVELOPMENT COOPERATION IN AN EMERGING FIELD OF ENGINEERING
- 2022
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Ingår i: 18th CDIO International Conference, CDIO 2022 - Proceedings. - : Reykjavík University. - 9789935965561 ; , s. 659-669
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Konferensbidrag (refereegranskat)abstract
- Four decades ago, a specific engineering BSc study program in Fire Safety Engineering was formed at Lund University, Sweden, and several Nordic universities have since included courses on such subjects in their own BSc og MSc programmes. The field of fire safety engineering encompasses topics from a wide range of engineering disciplines, including mathematics, physics, chemistry and advanced engineering courses such as heat transfer, thermodynamics and fluid dynamics. It is not immediately obvious how to balance the need for knowledge from fundamental, applied and specific courses to be taught within the discipline of fire safety engineering. Long standing cooperation across 12 Nordic universities and research institutions has made this distinction clearer and most recently this network secured Nordic funding for three years for a specific cooperation program in education, including PhD exchange programs and the development of a summer school for students of engineering, focusing on fire safety and energy. Specifically, four of these universities, through the authors of this paper, have been cooperating for a number of years within one of the key courses called "Enclosure Fire Dynamics", the study of how a fire develops in a building and how engineering methods based on classical physics and chemistry can be used to simulate the environment due to fire, allowing engineers and designers to test and compare various possible design solutions regarding building fire safety. This has required careful development of educational material in close cooperation between Nordic universities, following the CDIO principles. The fruitful cooperation has resulted in the production of comprehensive educational material such as textbooks, homework assignments, laboratory instructions and computer labs, to name a few examples of results. Most of the material is free of charge and available on the internet. This paper provides an example of how this has been achieved by a cross-Nordic collaboration on providing and developing educational material in an emerging engineering discipline.
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| 3. |
- Kostareva, Anna, et al.
(författare)
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Mice expressing L345P mutant desmin exhibit morphological and functional changes of skeletal and cardiac mitochondria
- 2008
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Ingår i: Journal of Muscle Research and Cell Motility. - : Springer Science and Business Media LLC. - 0142-4319 .- 1573-2657. ; 29:1, s. 25-36
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Tidskriftsartikel (refereegranskat)abstract
- Desmin mutations underlie inherited myopathies/cardiomyopathies with varying severity and involvement of the skeletal and cardiac muscles. We developed a transgenic mouse model expressing low level of the L345P desmin mutation (DESMUT mice) in order to uncover changes in skeletal and cardiac muscles caused by this mutation. The most striking ultrastructural changes in muscle from DESMUT mice were mitochondrial swelling and vacuolization. The mitochondrial Ca2+ level was significantly increased in skeletal and cardiac myocytes from DESMUT mice compared to wild type cells during and after contractions. In isolated DESMUT soleus muscles, contractile function and recovery from fatigue were impaired. A SHIRPA screening test for neuromuscular performance demonstrated decreased motor function in DESMUT compared to WT mice. Echocardiographic changes in DESMUT mice included left ventricular wall hypertrophy and a decreased left ventricular chamber dimension. The results imply that low levels of L345P desmin acts, at least partially, by a dominant negative effect on mitochondria.
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| 4. |
- Palmio, Johanna, et al.
(författare)
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Hereditary myopathy with early respiratory failure: occurrence in various populations
- 2014
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Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ. - 1468-330X .- 0022-3050. ; 85:3, s. 345-353
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Tidskriftsartikel (refereegranskat)abstract
- Objective Several families with characteristic features of hereditary myopathy with early respiratory failure (HMERF) have remained without genetic cause. This international study was initiated to clarify epidemiology and the genetic underlying cause in these families, and to characterise the phenotype in our large cohort. Methods DNA samples of all currently known families with HMERF without molecular genetic cause were obtained from 12 families in seven different countries. Clinical, histopathological and muscle imaging data were collected and five biopsy samples made available for further immunohistochemical studies. Genotyping, exome sequencing and Sanger sequencing were used to identify and confirm sequence variations. Results All patients with clinical diagnosis of HMERF were genetically solved by five different titin mutations identified. One mutation has been reported while four are novel, all located exclusively in the FN3 119 domain (A150) of A-band titin. One of the new mutations showed semirecessive inheritance pattern with subclinical myopathy in the heterozygous parents. Typical clinical features were respiratory failure at mid-adulthood in an ambulant patient with very variable degree of muscle weakness. Cytoplasmic bodies were retrospectively observed in all muscle biopsy samples and these were reactive for myofibrillar proteins but not for titin. Conclusions We report an extensive collection of families with HMERF with five different mutations in exon 343 of TTN, which establishes this exon as the primary target for molecular diagnosis of HMERF. Our relatively large number of new families and mutations directly implies that HMERF is not extremely rare, not restricted to Northern Europe and should be considered in undetermined myogenic respiratory failure.
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